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Abstract
The use of cannabis and its association with psychiatric disorders have been widely discussed, with modern studies highlighting the complex mechanisms of action and long-term risks. Research shows that cannabis use can have significant neuropsychological effects, impacting essential neurotransmitters such as dopamine and the endocannabinoid system, which may trigger or worsen psychiatric disorders like schizophrenia, anxiety, and depression. These mechanisms of action are related to the modulation of critical brain pathways that affect mood, memory, and behavior, influencing the vulnerability of predisposed individuals.
Clinical studies and systematic reviews point to a link between chronic cannabis use and the development of psychiatric symptoms, especially in genetically predisposed individuals or during critical developmental periods, such as adolescence. Furthermore, prolonged use is associated with structural and functional changes in the brain, impacting areas related to emotional processing and cognitive control. The risks include increased susceptibility to psychotic disorders and cognitive function impairment, with evidence suggesting that these effects may persist even after discontinuation of the substance.
Therefore, it is crucial for healthcare professionals to understand the complex interactions between cannabis use and mental health, recognizing the importance of a personalized and preventive approach. Considering individual vulnerability factors, such as genetic predisposition and family history, is essential to mitigate the risks associated with cannabis use. In conclusion, awareness of the mechanisms of action and potential long-term risks is fundamental to guiding clinical decisions, promoting appropriate interventions, and preventing adverse outcomes in vulnerable populations.
References
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Copyright (c) 2024 Michaella Nascimento Carsola , Maria Eduarda Azevedo Schmidt Zefer, Nadja Lopes Andreo, Larissa Vianna Fernandes De Andrade , Bruna Jacobus Boos, Helena Vergueiro de Moraes Ribeiro, Beatriz Mainardi da Cunha , Isabelly Menegueli Rufino, Isabela Cortez de Melo, Maria Clara Magalhães de Oliveira , Hellen Vitória Reis Damasceno
