Keywords
Infant
Systematic Review
How to Cite
Abstract
Introduction: Nutritional deficiencies in the maternal and child population represent a public health issue worldwide, contributing to the development of complications and unfavorable outcomes for growth and healthy development in cases of deficiencies. Objective: This article aims to investigate the effects of micronutrient supplementation in neonates, focusing on the prevention of nutritional deficiencies. Methods: This study is a systematic literature review conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol, using the databases MEDLINE, Scielo, and LILACS, with the keywords "nutritional supplements", "neonates". Studies involving newborns that investigated the effects of vitamin D, iron, zinc, and iodine supplementation were included. Included articles underwent dual review for enhanced accuracy. Results: A total of 270 articles were identified; however, 255 did not meet the inclusion criteria, leaving 15 studies for analysis. The studies showed positive outcomes in promoting health with the supplementation of micronutrients in neonates. Conclusion: Nutritional interventions demonstrate a broad spectrum of impact on neonatal health. Nevertheless, despite the positive findings of supplementation, individualized analysis and prescription are necessary, respecting the unique characteristics of each patient.
References
Nazli Hossain, Fatima H. Kanani, Shabana Ramzan, Robina Kausar, Shabana Ayaz, Rafiq Khanani, Lubna Pal, Resultados obstétricos e neonatais da suplementação materna de vitamina D: resultados de um ensaio aberto, randomizado e controlado de suplementação pré-natal de vitamina D no Paquistão Mulheres, The Journal of Clinical Endocrinology & Metabolism , Volume 99, Edição 7, 1 de julho de 2014, páginas 2448–2455, https://doi.org/10.1210/jc.2013-3491
Aly, Hany; Abdel-Hady, Hesham 1 .Vitamina D e o Neonato: Uma atualização. Journal of Clinical Neonatology 4(1):p 1-7, janeiro a março de 2015. | DOI: 10.4103/2249-4847.151155
NB Mathur, Ashish Saini, TK Mishra, Avaliação da adequação da suplementação de vitamina D em recém-nascidos prematuros de muito baixo peso ao nascer: um ensaio clínico randomizado, Journal of Tropical Pediatrics , Volume 62, Edição 6, dezembro de 2016, páginas 429–435, https ://doi.org/10.1093/tropej/fmv110
Gascoin, G., Gérard, M., Sallé, A., Becouarn, G., Rouleau, S., Sentilhes, L., & Coutant, R. (2017). Risco de baixo peso ao nascer e deficiências de micronutrientes em neonatos de mães após bypass gástrico: um estudo de caso-controle.. Cirurgia para obesidade e doenças relacionadas: jornal oficial da Sociedade Americana de Cirurgia Bariátrica , 13 8, 1384-1391. https://doi.org/10.1016/j.soard.2017.03.017 .
Lozoff B, Jimenez E, Walter T. Double burden of iron deficiency and low socio-economic status: a growth curve analysis of cognitive test scores to 19 years. Arch Pediatr Adolesc Med. 2006; In press. - doi: 10.1001/archpedi.160.11.1108
Elizabeth M. Curtis, Rebecca J. Moon, Stefania D'Angelo, Sarah R. Crozier, Nicholas J. Bishop, Jaya Sujatha Gopal Kothandapani, Stephen H. Kennedy, Aris T. Papageorghiou, Robert Fraser, Saurabh V. Gandhi, Inez Schoenmakers , Ann Prentice, Hazel M. Inskip, Keith M. Godfrey, M. Kassim Javaid, Richard Eastell, Cyrus Cooper, Nicholas C. Harvey, o MAVIDOS Trial Group, Suplementação de Vitamina D na Gravidez e Massa Óssea na Infância aos 4 Anos: Resultados de o Maternal Vitamin D Osteoporosis Study (MAVIDOS) Randomized Controlled Trial, JBMR Plus , Volume 6, Issue 7, 1 de julho de 2022, e10651, https://doi.org/10.1002/jbm4.10651
Oliver, C., Watson, C., Crowley, E., Gilroy, M., Page, D., Weber, K., Messina, D., & Cormack, B. (2019). Práticas de suplementação de vitaminas e minerais em bebês prematuros: uma pesquisa em unidades de cuidados especiais e intensivos neonatais na Austrália e na Nova Zelândia. Nutrientes , 12. https://doi.org/10.3390/nu12010051 .
Basta, D., Aboulghar, H., Ali, A., Akmal, D., & Baz, H. (2022). Ensaio randomizado controlado comparando duas doses de suplementação diária de vitamina D em neonatos prematuros. Revista internacional de ciências da saúde . https://doi.org/10.53730/ijhs.v6ns1.4760 .
Pérez-López FR, Pasupuleti V, Mezones-Holguin E, Benites-Zapata VA, Thota P, Deshpande A, Hernandez AV. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril. 2015 May;103(5):1278-88.e4. doi: 10.1016/j.fertnstert.2015.02.019. Epub 2015 Mar 23. PMID: 25813278.
Gonçalves JR. COMO ESCREVER UM ARTIGO DE REVISÃO DE LITERATURA. Revista JRG [Internet]. 10º de novembro de 2019 [citado 17º de maio de 2024];2(5):29-55. Disponível em: https://www.revistajrg.com/index.php/jrg/article/view/122
Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA satement. Phys Ther. 2009;89(9):873-80. Reprinted from Annals of Internal Medicine.
Byun SY, Bae MH, Lee NR, Han YM, Park KH. Association between vitamin D deficiency at one month of age and bronchopulmonary dysplasia. Medicine (Baltimore). 2021 Dec 3;100(48):e27966. doi: 10.1097/MD.0000000000027966. PMID: 35049200; PMCID: PMC9191292.
Hemmingway A, Fisher D, Berkery T, Murray DM, Kiely ME. Adherence to the infant vitamin D supplementation policy in Ireland. Eur J Nutr. 2021 Apr;60(3):1337-1345. doi: 10.1007/s00394-020-02334-w. Epub 2020 Jul 17. PMID: 32681322.
Uday S, Naseem S, Large J, Denmeade R, Goddard P, Preece MA, Dunn R, Fraser W, Tang JCY, Högler W. Failure of national antenatal vitamin D supplementation programme puts dark skinned infants at highest risk: A newborn bloodspot screening study. Clin Nutr. 2021 May;40(5):3542-3551. doi: 10.1016/j.clnu.2020.12.008. Epub 2020 Dec 11. PMID: 33358424.
Sass L, Vinding RK, Stokholm J, Bjarnadóttir E, Noergaard S, Thorsen J, Sunde RB, McGrath J, Bønnelykke K, Chawes B, Bisgaard H. High-Dose Vitamin D Supplementation in Pregnancy and Neurodevelopment in Childhood: A Prespecified Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open. 2020 Dec 1;3(12):e2026018. doi: 10.1001/jamanetworkopen.2020.26018. PMID: 33289844; PMCID: PMC7724557.
Carducci B, Keats EC, Bhutta ZA. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2021 Mar 16;3(3):CD000230. doi: 10.1002/14651858.CD000230.pub6. PMID: 33724446; PMCID: PMC8094617.
Shahshahani S, Sajedi F, Fatollahierad S. Effect of Zinc supplementation on child development: a systematic review and metaanalysis Protocol. Iran J Child Neurol. 2021 Winter;15(1):9-17. doi: 10.22037/ijcn.v15i1.22515. PMID: 33558810; PMCID: PMC7856432.
Brion, L.P., Heyne, R. & Lair, C.S. Role of zinc in neonatal growth and brain growth: review and scoping review. Pediatr Res 89, 1627–1640 (2021). https://doi.org/10.1038/s41390-020-01181-z
Boskabadi H, Maamouri G, Akhondian J, Ashrafzadeh F, Boskabadi A, Faramarzi R, Heidar E, Pourbadakhshan N, Shojaei SRH, Zakerihamidi M, Vatanchi AM, Sokhtanloo M, Razaghi N, Kalani F, Ataei H, Darabi A, Mousavi MS, Hakimiakhangan S, Bagheri F. Comparison of birth weights of neonates of mothers receiving vs. not receiving zinc supplement at pregnancy. BMC Pregnancy Childbirth. 2021 Mar 6;21(1):187. doi: 10.1186/s12884-021-03598-8. PMID: 33676424; PMCID: PMC7936407.
Olisaka CL, Iloh KK, Asinobi IN, Ubesie AC, Ikefuna AN, Ibe BC. Umbilical cord serum zinc in neonates delivered at the university of Nigeria teaching hospital, Enugu: Variation with gestational age. Niger J Clin Pract. 2022 Jul;25(7):997-1003. doi: 10.4103/njcp.njcp_16_22. PMID: 35859457.
Manapurath RM, Gadapani Pathak B, Sinha B, Upadhyay RP, Choudhary TS, Chandola TR, Mazumdar S, Taneja S, Bhandari N, Chowdhury R. Enteral Iron Supplementation in Preterm or Low Birth Weight Infants: A Systematic Review and Meta-analysis. Pediatrics. 2022 Aug 1;150(Suppl 1):e2022057092I. doi: 10.1542/peds.2022-057092I. PMID: 35921671.
Andersson O, Hellström-Westas L, Andersson D, Domellöf M. Effect of delayed versus early umbilical cord clamping on neonatal outcomes and iron status at 4 months: a randomised controlled trial. BMJ. 2011 Nov 15;343:d7157. doi: 10.1136/bmj.d7157. PMID: 22089242; PMCID: PMC3217058.
Liu D, Cheng Y, Qu P, Zhao D, Li S, Zeng L, Zhu Z, Qi Q, Mi B, Zhang B, Jing H, Yan H, Wang D, Dang S. The Interactions between Maternal Iron Supplementation and Iron Metabolism-Related Genetic Polymorphisms on Birth Outcomes: A Prospective Study in Chinese. J Nutr. 2023 Aug;153(8):2442-2452. doi: 10.1016/j.tjnut.2023.06.036. Epub 2023 Jun 28. PMID: 37390907.
Censi S, Watutantrige-Fernando S, Groccia G, Manso J, Plebani M, Faggian D, Mion MM, Venturini R, Andrisani A, Casaro A, Vita P, Avogadro A, Camilot M, Scaroni C, Bertazza L, Barollo S, Mian C. The Effects of Iodine Supplementation in Pregnancy on Iodine Status, Thyroglobulin Levels and Thyroid Function Parameters: Results from a Randomized Controlled Clinical Trial in a Mild-to-Moderate Iodine Deficiency Area. Nutrients. 2019 Nov 4;11(11):2639. doi: 10.3390/nu11112639. PMID: 31689890; PMCID: PMC6893432.
Gebreegziabher T, Woltamo T, Thomas DG, Kennedy TS, Stoecker BJ. Iodine supplementation of lactating women and assessment of infant visual information processing and maternal and infant thyroid function: A randomized trial. PLoS One. 2019 Oct 7;14(10):e0223348. doi: 10.1371/journal.pone.0223348. PMID: 31589645; PMCID: PMC6779247.
Tinna T, Ounjaijean S, Tongsong T, Traisrisilp K. Comparison of the Effectiveness of Universal and Targeted Iodine Supplementation in Pregnant Women: A Randomized Controlled Trial. Gynecol Obstet Invest. 2020;85(2):189-195. doi: 10.1159/000506800. Epub 2020 Mar 11. PMID: 32160632.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Karla Daniella Almeida Oliveira de Brito, Ellen Vitória Rodrigues de Lima Freire, Jaine Amorim Araujo, Adonay Guedes Cirino, Renan Barros Braga, Ana Carolina Carvalho de Lourdes, Beatriz Pinheiro Borges Neta, Andressa de Sousa Carvalho Sá, Victória de Brito Melo, Anna Clara Cavalcante de Moura, Rita de Cássia Gomes Costa, Thayse Souza dos Santos, Carlos Antonio Teixiera de Lima Sampaio