COMPARISON BETWEEN PLUMMER'S DISEASE AND GRAVES' DISEASE: CLINICAL, DIAGNOSTIC AND THERAPEUTIC DIFFERENCES.

Authors

  • Samuel Antonio Andrade De Moraes Graduando em Medicina - Centro Universitário Uninovafapi
  • Fernanda Alves de Souza Graduada em Medicina - Universidade Salvador
  • Germano Danielli Graduando em Medicina - UNIVERSIDADE DE PASSO FUNDO
  • Cecília Maria Rodrigues de França Graduando em Medicina - Centro Universitário de Caratinga UNEC
  • Pâmela Marina Borges Ribeiro Graduando em Medicina - ITPAC- PORTO NACIONAL
  • Alex Hennemann Graduando em Medicina - ITPAC Porto Nacional
  • Gabrielle Marcantes Menon Graduando em Medicina - CENTRO UNIVERSITÁRIO DE PATO BRANCO - UNIDEP
  • Lívia de Castro Martinez Graduando em Medicina - Centro Universitário Uninovafapi
  • William Alberto Hermida Artunduaga Graduando em Medicina - Universidade Estadual Do Oeste do Paraná (Cascavel)
  • Juliana Fernandes Areal Carrizo Graduando em Medicina - Universidade do Oeste Catarinense
  • Kevin Enrrique Andrade Pinheiro Graduando em Medicina - UNIVERSIDADE FEDERAL DE PERNAMBUCO
  • João Florêncio Monteiro Neto Graduando em Medicina Universidade CEUMA
  • Luis Otávio Galho Mendonça Graduando em Medicina - Universidade Católica de Pelotas
  • Monise Martins Portela Fontenele Vilâny Graduando em Medicina Unichristus
  • Mariana Loiola Marques Barbosa Graduando em Medicina - Centro Universitário Unifacid
  • Elvis Bezerra de Souza Sales Graduando em Medicina Universidad Privada Abierta Latinoamericana
  • Caroline Kosteczka Cheres Saad Graduando em Medicina Faculdades Pequeno Príncipe
  • José Gabriel de Araújo Novais Graduando em Medicina Faculdade de Ciências Médicas do Pará (FACIMPA)
  • Valery Zandavalli Olsen Graduando em Medicina Universidade do Alto Vale do Rio do Peixe
  • Cristiane de Carvalho Rios Graduando em Medicina Faculdade Metropolitana de Porto Velho – UNNESA
  • Amanda Monteiro Gimenes Soares Graduando em Medicina - Centro universitário das Américas -FAm
  • Éllen Araujo Martins Maia Graduando em Medicina - Centro Universitário Uninovafapi

DOI:

https://doi.org/10.36557/2674-8169.2024v6n7p921-930

Keywords:

Hyperthyroidism, Plummer's Disease, Graves' Disease, Differential Diagnosis, Thyroid Therapies, Autoimmunity.

Abstract

Plummer's Disease and Graves' Disease are prevalent hyperthyroid conditions with distinct pathophysiological mechanisms. While Plummer's Disease is characterized by autonomous nodules that produce hormones independently of TSH, Graves' Disease is an autoimmune condition with diffuse thyroid stimulation due to antibodies against the TSH receptor. Methodology: The research was conducted through online access to scientific databases such as Google Scholar, National Library of Medicine (PubMed), Virtual Health Library (BVS), and Scientific Electronic Library Online (SCIELO) for article selection, using keywords present in the descriptors: Plummer's Disease, Hyperthyroidism, Thyroid Ultrasonography, Graves' Disease, TSH Receptor Antibodies, and Exophthalmos. Results: Patients with Plummer's Disease present insidious hyperthyroid symptoms associated with palpable thyroid nodules, diagnosed by scintigraphy showing heterogeneous uptake. In Graves' Disease, in addition to the classic signs of hyperthyroidism, exophthalmos and other autoimmune symptoms are common, with diagnosis confirmed by TSH receptor antibodies and scintigraphy with diffuse uptake. Treatments for Plummer's Disease include radioactive iodine therapy and surgery, while for Graves' Disease, the initial approach is with antithyroid medications, followed by radioactive iodine therapy or surgery in refractory cases. Final considerations: Differentiating between Plummer's Disease and Graves' Disease is essential for effective treatment. Plummer's Disease requires interventions focused on hyperfunctioning nodules, while Graves' Disease necessitates a comprehensive approach that includes managing autoimmune manifestations. Personalized treatment based on the specific etiology of hyperthyroidism is crucial to optimizing therapeutic outcomes and patient quality of life. Keywords: Hyperthyroidism, Plummer's Disease, Graves' Disease, Differential Diagnosis, Thyroid Therapies, Autoimmunity

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References

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Published

2024-07-09

How to Cite

Moraes , S. A. A. D., Souza , F. A. de, Danielli , G., França, C. M. R. de, Ribeiro , P. M. B., Hennemann, A., Menon, G. M., Martinez, L. de C., Artunduaga, W. A. H., Carrizo, J. F. A., Pinheiro, K. E. A., Neto , J. F. M., Mendonça, L. O. G., Vilâny , M. M. P. F., Barbosa, M. L. M., Sales , E. B. de S., Saad , C. K. C., Novais , J. G. de A., Olsen, V. Z., Rios , C. de C., Soares , A. M. G., & Maia , Éllen A. M. (2024). COMPARISON BETWEEN PLUMMER’S DISEASE AND GRAVES’ DISEASE: CLINICAL, DIAGNOSTIC AND THERAPEUTIC DIFFERENCES. Brazilian Journal of Implantology and Health Sciences, 6(7), 921–930. https://doi.org/10.36557/2674-8169.2024v6n7p921-930

Issue

Vol. 6 No. 7 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Literature Review

License

Copyright (c) 2024 Samuel Antonio Andrade De Moraes , Fernanda Alves de Souza , Germano Danielli , Cecília Maria Rodrigues de França, Pâmela Marina Borges Ribeiro , Alex Hennemann, Gabrielle Marcantes Menon, Lívia de Castro Martinez, William Alberto Hermida Artunduaga, Juliana Fernandes Areal Carrizo, Kevin Enrrique Andrade Pinheiro, João Florêncio Monteiro Neto , Luis Otávio Galho Mendonça, Monise Martins Portela Fontenele Vilâny , Mariana Loiola Marques Barbosa, Elvis Bezerra de Souza Sales , Caroline Kosteczka Cheres Saad , José Gabriel de Araújo Novais , Valery Zandavalli Olsen, Cristiane de Carvalho Rios , Amanda Monteiro Gimenes Soares , Éllen Araujo Martins Maia

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