Cardiovascular diseases as main risk factor for periodontal medicine
PDF (Português (Brasil))

Keywords

Periodontal disease, Etiology, Pathogenesis, Systemic diseases, Cardiovascular diseases.

How to Cite

Antunes de Medeiros, R., Monteiro da Silva, Y., Marçal Soares Miranda, Y., Resque Beckmann Carvalho, T., Faciola Pessôa de Oliveira, P. G. ., Antunes Esteves, R. ., Fernandes de Menezes, S. A. ., Roberto de Souza Fonseca, R., & Brito Tanaka, E. (2022). Cardiovascular diseases as main risk factor for periodontal medicine: literature review. Brazilian Journal of Implantology and Health Sciences, 4(6), 03–23. https://doi.org/10.36557/2674-8169.2022v4n6p03-23

Abstract

Background: Periodontal medicine has been growing and the demand for knowledge about the effects of periodontal disease and periodontal therapy in systemic health has increased. This study described a narrative review of the literature on the correlation between cardiovascular diseases (CVDs) and periodontal disease (PD). Materials and Methods: A literature search were performed on the platforms PubMed, SciELO, MEDLINE, LILACS, using the keywords “Chronic Periodontitis” AND/OR “Periodontal Diseases” AND/OR “Cardiovascular Diseases” AND/OR “Periodontal Microbiology” AND/OR “Cardiopathies AND/OR Atherosclerosis” and the inclusion criteria were articles published from 2015 to 2020, in Portuguese and English. Results: Although the connection between CVDs and PD is well documented, evidence for the cause effect of this relationship remains to be clarified. Results: CVDs such as atherosclerosis have pro-inflammatory characteristics, and the continuous adhesion of adipose cells to the inner endothelial walls promotes possible damage to the patient's entire cardiovascular system. Furthermore, it is known that periodontal bacteria when they fall into the bloodstream may have an affinity for atherosclerotic plaques, aggravating the pro-inflammatory systemic state, so understanding how the interaction between these two pathologies works is of great importance to the dental surgeon in order to proceed with his plan of treatment. Conclusions: The focus of the studies captured in this work was on the eti-opathogenesis, mechanism of action and clinical care between PD and CVDs and based on the analyzes we sought to update clinical and scientific evidence and hypotheses for significant associations between these two pathologies.

https://doi.org/10.36557/2674-8169.2022v4n6p03-23
PDF (Português (Brasil))

References

Organização Pan-Americana da Saúde. OPAS/OMS- Doenças Cardiovasculares [acesso em: 30 de setembro de 2020]. Disponível em: https://www.paho.org/bra/index.php?option=com_content&view=article&id=5253:doencas-cardiovasculares&Itemid=1096.

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, et al. Heart Disease and Stroke Statistics-2018 Update: A Report from the American Heart Association. Circulation. 2018, 20; 137(12): e67-e492.

Brieler J, Breeden MA, Tucker J. Cardiomyopathy: An Overview. Am Fam Physician. 2017, 15, 96(10): 640-646.

McKenna WJ, Maron BJ, Thiene G. Classification, Epidemiology, and Global Burden of Cardiomyopathies. Circ Res. 2017, 15, 121(7): 722-730.

Orlandi M, Graziani F, D'Aiuto F. Periodontal therapy and cardiovascular risk. Periodontol 2000. 2020, 83(1): 107-124.

Ying Ouyang X, Mei Xiao W, Chu Y, Ying Zhou S. Influence of periodontal intervention therapy on risk of cardiovascular disease. Periodontol 2000. 2011, 56 (1): 227-57.

Herrera D, Molina A, Buhlin K, Klinge B. Periodontal diseases and association with atherosclerotic disease. Periodontol 2000. 2020, 83(1): 66-89.

Liu W, Cao Y, Dong L, Zhu Y, Wu Y, Lv Z, et al. Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis. Cochrane Database Syst Rev. 2019, 31; 12(12): CD009197.

Li C, Lv Z, Shi Z, Zhu Y, Wu Y, Li L, et al. Periodontal therapy for the management of cardiovascular disease in patients with chronic periodontitis. Cochrane Database Syst Rev. 2017, 7; 11(11): CD009197.

Aoyama N, Kobayashi N, Hanatani T, Ashigaki N, Yoshida A, Shiheido Y, et al. Periodontal condition in Japanese coronary heart disease patients: A comparison between coronary and non-coronary heart diseases. J Periodontal Res. 2019, 54(3): 259-265.

Kantarci A, Hasturk H, Van Dyke TE. Host-mediated resolution of inflammation in periodontal diseases. Periodontol 2000. 2006; 40:144-63.

Hasturk H, Kantarci A, Goguet-Surmenian E, Blackwood A, Andry C, Serhan CN, et al. Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol. 2007, 15;179(10):7021-9.

Hong BY, Furtado Araujo MV, Strausbaugh LD, Terzi E, Ioannidou E, Diaz PI. Microbiome profiles in periodontitis in relation to host and disease characteristics. PLoS One. 2015, 18; 10(5):e0127077.

Schincaglia GP, Hong BY, Rosania A, Barasz J, Thompson A, Sobue T, et al. Clinical, Immune, and Microbiome Traits of Gingivitis and Peri-implant Mucositis. J Dent Res. 2017, 96(1):47-55.

Goulart AC, Armani F, Arap AM, Nejm T, Andrade JB, Bufarah HB, et al. Relationship between periodontal disease and cardiovascular risk factors among young and middle-aged Brazilians. Cross-sectional study. Sao Paulo Med J. 2017, 135(3): 226-233.

Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res. 2003; 82(2):82-90.

Cullinan MP, Palmer JE, Faddy MJ, Westerman B, Carle AD, West MJ, et al. The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): A Randomized Controlled Trial. J Periodontol. 2015, 86(7): 847-55.

Bui FQ, Almeida-da-Silva CL, Huynh B, Trinh A, Liu J, Woodward J, et al. Association between periodontal pathogens and systemic disease. Biomed J. 2019, 42 (1): 27-35.

Loos BG, Van Dyke TE. The role of inflammation and genetics in periodontal disease. Periodontol 2000. 2020, 83(1): 26-39.

Curtis MA, Diaz PI, Van Dyke TE. The role of the microbiota in periodontal disease. Periodontol 2000. 2020, 83(1):14-25.

Abusleme L, Dupuy AK, Dutzan N, Silva N, Burleson JA, Strausbaugh LD, et al. The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation. ISME J. 2013, 7(5):1016-25.

Holmlund A, Lampa E, Lind L. Oral health and cardiovascular disease risk in a cohort of periodontitis patients. Atherosclerosis. 2017; 262:101-106.

Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri-implant diseases and conditions - Introduction and key changes from the 1999 classification. J Clin Periodontol. 2018; 45 Suppl 20:S1-S8.

Liccardo D, Cannavo A, Spagnuolo G, Ferrara N, Cittadini A, Rengo C, et al. Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease. Int J Mol Sci. 2019, 20; 20(6):1414.

Marsh PD. Microbial ecology of dental plaque and its significance in health and disease. Adv Dent Res. 1994; 8(2):263-71.

Beck JD, Papapanou PN, Philips KH, Offenbacher S. Periodontal Medicine: 100 Years of Progress. J Dent Res. 2019, 98(10):1053-1062.

Kozarov E, Huber K, Wojta J. Infection-associated biomarkers of inflammation in atherosclerosis. Curr Pharm Des. 2015; 21(13):1776-82.

Sekinishi A, Suzuki J, Aoyama N, Ogawa M, Watanabe R, Kobayashi N, et al. Periodontal pathogen Aggregatibacter actinomycetemcomitans deteriorates pressure overload-induced myocardial hypertrophy in mice. Int Heart J. 2012;53(5):324-30.

Graziani F, Karapetsa D, Alonso B, Herrera D. Nonsurgical and surgical treatment of periodontitis: how many options for one disease? Periodontol 2000. 2017; 75(1):152-188.

de Arruda CA, Freire C. Protocolos de atendimento a pacientes cardiopatas no consultório odontológico. Recife: Faculdade Integrada de Pernambuco (FACIPE), 2018. Trabalho de Conclusão de Curso em odontologia.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2022 Rebeca Antunes de Medeiros, Yngrid Monteiro da Silva, Yasmim Marçal Soares Miranda, Tábata Resque Beckmann Carvalho, Paula Gabriela Faciola Pessôa de Oliveira, Renata Antunes Esteves, Silvio Augusto Fernandes de Menezes, Ricardo Roberto de Souza Fonseca, Erich Brito Tanaka