Associations between folic acid supplementation during pregnancy and risk of autism spectrum disorder: An Integrative Review

Authors

  • Ana Eliza Riola Chemin Universidade do Oeste Paulista (UNOESTE)
  • Kerol Martiniano Porcelli Universidade do Oeste Paulista (UNOESTE)
  • José Eduardo Felipe Souza dos Santos Universidade do Sul de Santa Catarina (UNISUL)
  • Alana Sales Guimarães Faculdade de Medicina de Itajubá (FMIT)
  • Angelica Rodrigues Mendes Medeiros Universidad del Pacífico (UPACIFICO)
  • Gabriel de Moura Lima Centro Universitário de Valença (UNIFAA)
  • Lana Nicolle Gomes Bernardo Saraiva Universidade de Rio Verde (UniRV)
  • Maria Julia Gomes Ferreira Santos Universidade de Marilia (UNIMAR)
  • Maria Vitória Lopes Cordeiro Universidade de Marilia (UNIMAR)
  • Rafael Leituga de Carvalho Cavalcante Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
  • Ariane Abreu Tsutsumi Faculdade São Leopoldo Mandic (FSLM)
  • Marina Silva Prado Faculdade São Leopoldo Mandic (FSLM)

DOI:

https://doi.org/10.36557/2674-8169.2024v6n5p1689-1699

Keywords:

Folic acid; Pregnancy; Autism Spectrum Disorder (ASD); Supplementation.

Abstract

This integrative review examines the association between folic acid supplementation during pregnancy and the risk of Autism Spectrum Disorder (ASD) in children. The search included articles published in the last decade, resulting in the selection of eight relevant epidemiological and clinical studies. The findings indicate a consistent trend that folic acid supplementation, both before and during pregnancy, is associated with a lower risk of ASD in offspring. However, some variations were observed regarding the timing and duration of supplementation, as well as in different populations studied. This review highlights the importance of folic acid supplementation as a potential preventive measure for ASD and underscores the need for further research to fully elucidate this relationship and its clinical implications.

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References

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Published

2024-05-23

How to Cite

Riola Chemin, A. E., Martiniano Porcelli, K., Felipe Souza dos Santos, J. E., Sales Guimarães, A., Rodrigues Mendes Medeiros, A., de Moura Lima, G., Gomes Bernardo Saraiva, L. N., Gomes Ferreira Santos, M. J., Lopes Cordeiro, M. V., Leituga de Carvalho Cavalcante, R., Abreu Tsutsumi, A., & Silva Prado, M. (2024). Associations between folic acid supplementation during pregnancy and risk of autism spectrum disorder: An Integrative Review. Brazilian Journal of Implantology and Health Sciences, 6(5), 1689–1699. https://doi.org/10.36557/2674-8169.2024v6n5p1689-1699

Issue

Vol. 6 No. 5 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Systematic Review

License

Copyright (c) 2024 Ana Eliza Riola Chemin, Kerol Martiniano Porcelli, José Eduardo Felipe Souza dos Santos, Alana Sales Guimarães, Angelica Rodrigues Mendes Medeiros, Gabriel de Moura Lima, Lana Nicolle Gomes Bernardo Saraiva, Maria Julia Gomes Ferreira Santos, Maria Vitória Lopes Cordeiro, Rafael Leituga de Carvalho Cavalcante, Ariane Abreu Tsutsumi, Marina Silva Prado

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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