Abstract
This review aims to evaluate the pathophysiological aspects, as well as to evaluate the role of ultrasonography during pregnancies complicated by GDM. For this, the progress of the research began with the definition of the descriptors indexed by the Medical Subject Headings (MeSH) and by the Health Sciences Descriptor (DeCS). For the searches, the PubMed databases were consulted, through the virtual access of the National Center for Biotechnology Information (NCBI); and Lilacs, through electronic access from the Virtual Health Library (VHL). Articles were identified and selected from the MeSH strategy with the following terms related to the topic addressed: Gestational diabetes, glucose and pregnancy, ultrasound and fetal vitality, fetal vitality, polyhydramnios and gestational diabetes. As a result, we saw that complications resulting from DM and adverse perinatal outcomes are directly related to maternal metabolic control, from the phase, with regard to the programming of pregnancy, since DM is strongly associated with cogenital anomalies (CAs ), regarding complications in the last trimester of pregnancy, highlighting the large fetus for gestational age (macrosomic) as risk predictors, associated with polyhydramnios, since excess glucose in maternal blood crosses the placenta, leading to fetal hyperglycemia, and this, in turn, triggers fetal osmotic diuresis.
References
ANGUEIRA, Anthony R. et al. New insights into gestational glucose metabolism: Lessons learned from 21st century approaches. Diabetes, v. 64, n. 2, p. 327–334, 2015.
ARTASENSI A et al. Type 2 diabetes mellitus: A review of multi-target drugs. Molecules [revista en Internet] 2020 [acceso 7 de marzo de 2022]; 25(8): 1-20. p. 1–20, 2020.
BOYBEYI‐TURER, Ozlem et al. A rare congenital esophageal anomaly mimicking an isolated esophageal atresia : Kluth Type IV 1a membranous esophageal atresia . Congenital Anomalies, v. 61, n. 6, p. 208–211, 2021.
CAMELO CASTILLO, W. et al. Association of adverse pregnancy outcomes with glyburide versus insulin in women with gestational diabetes. JAMA Pediatr. 169, 452– 458 (2015).
DALFRÀ, Maria Grazia et al. Genetics and Epigenetics: New Insight on Gestational Diabetes Mellitus. Frontiers in Endocrinology, v. 11, n. December, p. 1–12, 2020.
DASHE, Jodi S.; PRESSMAN, Eva K.; HIBBARD, Judith U. SMFM Consult Series #46: Evaluation and management of polyhydramnios. American Journal of Obstetrics and Gynecology, v. 219, n. 4, p. B2–B8, 2018.
DI CIANNI G, MICCOLI R, VOLPE L, LENCIONI C, DEL PRATO S. Intermediate
metabolism in normal pregnancy and in gestational diabetes. Diabetes Metab Res Rev;19:259–270. 2003.
GABBAY-BENZIV, Rinat. Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis. World Journal of Diabetes, v. 6, n. 3, p. 481, 2015.
GARBAGNATI, Marta et al. Ultrasound predictors of adverse outcome in pregnancy complicated by pre-existing and gestational diabetes. Acta Obstetricia et Gynecologica Scandinavica, v. 101, n. 7, p. 787–793, 2022.
GOLETZKE, Janina et al. Effect of a low-glycemic load diet intervention on maternal and pregnancy outcomes in obese pregnant women. Nutrients, v. 13, n. 3, p. 1–14, 2021.
GOVEIA, P. ET AL. Lifestyle intervention for the prevention of diabetes in women with previous gestational diabetes mellitus: a systematic review and meta-analysis. Front. Endocrinol. 9, 583. 2018.
HADDEN DR, MCLAUGHLIN C. Normal and abnormal maternal metabolism during pregnancy. Semin Fetal Neonatal Med 2009;14:66–71.2009.
HOANG, Thanh T. et al. Original Findings and Updated Meta-Analysis for the Association between Maternal Diabetes and Risk for Congenital Heart Disease Phenotypes. American Journal of Epidemiology, v. 186, n. 1, p. 118–128, 2017.
KIM, Shin Y.; SHARMA, Andrea J.; CALLAGHAN, William M. Gestational diabetes and childhood obesity: What is the link? Current Opinion in Obstetrics and Gynecology,
v. 24, n. 6, p. 376–381, 2012.
LALOR, Joan G. et al. Biophysical profile for fetal assessment in high risk pregnancies. Cochrane Database of Systematic Reviews, n. 2, 2008.
MAZAKI-TOVI S, KANETY H, PARIENTE C, ET AL.. Insulin sensitivity in late gestation and early postpartum period: the role of circulating maternal adipokines. Gynecol Endocrinol 2011;27:725–731.
MING, W.K.; DING, W.; ZHANG, C.J.; ZHONG, L.; LONG, Y.; LI, Z.; SUN, C.; WU,
Y.; CHEN, H.; CHEN, H.; et al. The effect of exercise during pregnancy on gestational diabetes mellitus in normal-weight women: A systemic review and meta-analysis. BMC Pregnancy Childbirth, 18, 440. 2018.
MCINTYRE, H. David et al. Gestational diabetes mellitus. Nature Reviews Disease Primers, v. 5, n. 1, 2019.
MILLS, James L. Malformations in infants of diabetic mothers. Teratology 25:385-94. 1982. Birth defects research. Part A, Clinical and molecular teratology, v. 88, n. 10, p. 769–778, 2010.
MODZELEWSKI, Robert et al. Gestational Diabetes Mellitus — Recent Literature Review. p. 1–14, 2022.
NEGRATO, Carlos Antonio et al. Glycemic and nonglycemic mechanisms of congenital malformations in hyperglycemic pregnancies: a narrative review. Archives of Endocrinology and Metabolism, 2022.
NOMURA, Roseli Mieko Yamamoto et al. Assessment of Fetal Well - Being and Perinatal Outcome in Pregnancies After Roux - En - Y Gastric Bypass. v. 56, n. 6, p. 670– 674, 2010.
NOMURA, Roseli Mieko Yamamoto; MIYADAHIRA, Seizo; ZUGAIB, Marcelo. Avaliação da vitalidade fetal anteparto. Revista Brasileira de Ginecologia e Obstetrícia, v. 31, n. 10, p. 513–526, 2009.
PICCINNI, Marie Pierre et al. Cytokines, Hormones and Cellular Regulatory Mechanisms Favoring Successful Reproduction. Frontiers in Immunology, v. 12, n. July, p. 1–14, 2021.
PREDA, Agnesa et al. Transient Polyhydramnios during Pregnancy Complicated with Gestational Diabetes Mellitus: Case Report and Systematic Review. Diagnostics, v. 12, n. 6, p. 1–18, 2022.
ROSTA, Klara et al. Is vaginal progesterone treatment associated with the development of gestational diabetes? A retrospective case–control study. Archives of Gynecology and Obstetrics, v. 298, n. 6, p. 1079–1084, 2018.
SAMPAIO, Yanara et al. Gestational diabetes and overt diabetes first diagnosed in pregnancy: Characteristics, therapeutic approach and perinatal outcomes in a public healthcare referral center in Brazil. Archives of Endocrinology and Metabolism, v. 65, n. 1, p. 79–84, 2021.
SHABANI ZANJANI, Mansoureh et al. Fetal cerebral hemodynamic in gestational diabetic versus normal pregnancies: A Doppler velocimetry of middle cerebral and umbilical arteries. Acta Neurologica Belgica, v. 114, n. 1, p. 15–23, 2014.
SNYDER, Hannah. Literature review as a research methodology: An overview and guidelines. Journal of Business Research, v. 104, n. August, p. 333–339, 2019.
TABIB, Avisa et al. Cardiac malformations in fetuses of gestational and pre gestational diabetic mothers. Iranian Journal of Pediatrics, v. 23, n. 6, p. 664–668, 2013.
URSACHEN, Das Polyhydramnion; THERAPIE, Diagnostik. Polyhydramnios : Causes, Diagnosis and Therapy. p. 1241–1246, 2013
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Luísa de Oliveira e Silva , Laís Silva Sousa , Bruna Lagemann , Laiz Rosa e Andrade , Larissa Borges Gregoletto , Melissa Uchôa da Silva , Kelvin Lucas Rodrigues Martins , Dyago Silva Santos , Isadora Lessa Silva Damasceno , Mariana Pereira Dutra , André Luiz da Silva Aranha , Carlos Eduardo Mello Da Rocha, Wanderson Paiva dos Santos