Keywords
Oral Neoplasms
Dentistry
How to Cite
Abstract
Introduction: Oral squamous cell carcinoma (SCB) is a type of malignant neoplasm, considered one of the tumors with the highest incidence rate in the Brazilian population, corresponding to 90% to 95% of cancer cases affecting the oral cavity and oropharynx. The Human Papillomavirus (HPV) is a virus that has an affinity for epithelial tissue, comprises several subtypes and is often associated with the formation of benign and malignant neoplasms. Objective: Therefore, the present research aims to address the correlation between CEB and HPV. Methodology: The study consists of a literature review, based on scientific articles searched in the Scielo, PubMed/Medline and LILACS databases, using the descriptors: "Human Papillomavirus"; "Oral Neoplasms" and "Dentistry". Original articles, literature reviews, and case reports in Portuguese, English, and Spanish were included, without taking into account the periods of publication. Results: HPV has some virus subtypes that are related to benign lesions and others with carcinogenic potential. The latter is directly linked to the protein encoded by the E2 gene, which inhibits the expression of the E6 and E7 genes, which are active in cell immortalization. The absence of these genes results in excessive and unregulated cellular degradation, which favors the accumulation of mutations and the occurrence of chromosomal aberrations. Conclusion: There is a need for more specific studies to understand the role of HPV as a carcinogen. Despite the diversity of factors seen in the literature, there are still no conclusive studies relating HPV as a risk factor for oral carcinoma.
Keywords: Human Papillomavirus; Oral Neoplasms; Dentistry.
References
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Copyright (c) 2024 Maria Gabriela de Souza Andrade Brandão, Louise Bárbara Azevedo da Silva, Joab Gabriel do Nascimento Santos, Brenda Camila Santos da Silva, Ana Luísa Gomes Lourenço, Jemima Hanã de Oliveira Batista dos Santos, Anna Beatriz Arruda Barroso de Moraes, Maurício Alves Martins, Glauciele Souza de Santana, Ilídia Carol dos Santos Pereira, Edith Maria Feitosa El-Deir, Anna Luiza Brilhante Ribeiro Silveira, Bárbara Guedes Alcoforado, Ítalo Alencar Barros Araújo