Keywords
Tratamento
Sistema imune
Desafios
How to Cite
Abstract
The work addresses multiple sclerosis (MS) as a complex disease of the central nervous system, discussing the interaction between inflammatory processes, demyelination, and neuroaxonal degeneration. It emphasizes the importance of immune cells in penetrating the blood-brain barrier and forming demyelinating lesions. While treatments for the relapsing form of MS are effective, options for the non-relapsing progressive form are limited. Through a meticulous review of the literature, various therapeutic approaches are presented, including natural substances, modification of the intestinal microbiome, rehabilitation therapy, and new pharmacological therapies such as BTK inhibitors and ocrelizumab. Challenges such as managing fatigue, treating patients with concomitant diseases and the elderly, as well as issues related to reproductive health, are highlighted. The study underscores the need for a multidisciplinary and personalized approach, recognizing the complexity of MS and the ongoing importance of research to improve outcomes and quality of life for patients.
References
ABDORREZANASER MOGHADASI et al. The prevalence of cancer in patients with Multiple Sclerosis (MS) who were under treatment with Natalizumab (Tysabri): A systematic review and meta-analysis. International Journal of Preventive Medicine, v. 14, n. 1, p. 114–114, 1 jan. 2023.
BRASIL. Lei Nº 12.853. Brasília: 14 de agosto de 2013.
DALIBOR ZIMEK; MIKLUSOVA, M.; MARES, J. Overview of the Current Pathophysiology of Fatigue in Multiple Sclerosis, Its Diagnosis and Treatment Options – Review Article. Neuropsychiatric Disease and Treatment, v. Volume 19, p. 2485–2497, 1 nov. 2023.
DUAN, H. et al. Rehabilitation treatment of multiple sclerosis. Frontiers in Immunology, v. 14, 6 abr. 2023.
DUARTE-SILVA, E.; MEUTH, S. G.; PEIXOTO, C. A. The role of iron metabolism in the pathogenesis and treatment of multiple sclerosis. Frontiers in Immunology, v. 14, p. 1137635, 17 mar. 2023.
FATHALLAH, S.; AHMED A.H. ABDELLATIF; SAADELDIN, M. Unleashing nature’s potential and limitations: Exploring molecular targeted pathways and safe alternatives for the treatment of multiple sclerosis (Review). Medicine international, v. 3, n. 5, 17 ago. 2023.
HASHEMI, B. et al. The effect of probiotics on immune responses and their therapeutic application: A new treatment option for multiple sclerosis. Biomedicine & Pharmacotherapy, v. 159, p. 114195, mar. 2023.
KHAN, Z.; GHANSHYAM DAS GUPTA; MEHAN, S. Cellular and Molecular Evidence of Multiple Sclerosis Diagnosis and Treatment Challenges. Journal of Clinical Medicine, v. 12, n. 13, p. 4274–4274, 26 jun. 2023.
KRÄMER, J. et al. Bruton tyrosine kinase inhibitors for multiple sclerosis. Nature Reviews Neurology, v. 19, n. 5, p. 289–304, 1 maio 2023.
LI, Q. et al. Macular edema after siponimod treatment for multiple sclerosis: a case report and literature review. BMC Neurology, v. 23, p. 286, 31 jul. 2023.
MA, X. et al. Recent Progress in Multiple Sclerosis Treatment Using Immune Cells as Targets. Pharmaceutics, v. 15, n. 3, p. 728–728, 22 fev. 2023.
MARTIN, S.; SCHNEIDER, R. Multiple sclerosis and exercise—A disease-modifying intervention of mice or men? Frontiers in Neurology, v. 14, 10 out. 2023.
MONTALBAN, X. et al. Real‐world evaluation of ocrelizumab in multiple sclerosis: A systematic review. Annals of clinical and translational neurology, 2 fev. 2023.
SAMJOO, I. A. et al. Comparative efficacy of therapies for relapsing multiple sclerosis: a systematic review and network meta-analysis. v. 12, n. 7, 1 jul. 2023.
VALIŠ, M. et al. The Benefits and Risks of Switching from Fingolimod to Siponimod for the Treatment of Relapsing–Remitting and Secondary Progressive Multiple Sclerosis. Drugs in R&D, v. 23, n. 4, p. 331–338, 1 dez. 2023.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Leonardo Pereira Levada, Milena Beatriz Benício Neves, Ana Beatriz Teles de Almeida, João Bosco Araújo Diniz Segundo, Ricardo Teixeira Campos de Medeiros, Renata Antonia Aguiar Ribeiro, Lara Maria Barros de Souza, Maria Emanuelle Ferreira de Morais, Demétrya Victória Pereira Martins Duarte, Maria Teresa Gurgel Amorim, Ana Karoliny Teles de Almeida, João Victor Nascimento de Sousa, Ana Carolina Adriano Borges Dério, Polliany Chaves de Oliveira, João Lucas Filgueira Nogueira