Perspectivas Terapêuticas para a Doença de Parkinson: Investigando Neuroprotetores e Modificadores de Progressão

José Lucas Moura Vasconcelos; Andressa Karoline Alves Leite; Anisia da Silva Teixeira; Bárbara Dayann Rocha Barreto; Carla Maria Zanelli  Pinaty; Caroline Fernanda Alexandre Henrique; Dhemer Jhony Dall'Agnol; Giovanna Vieira Brito; Giovana Pereira Viana; Heloísa Maria Marson Bonatti; Julia Maria Prestes Capatto; Kauara Marcelino Gonçalves; Larissa Cunha Hipolito  Rodrigues; Luana Cruz Nunes  Godinho; Maria Eugênia Abílio Lima; Maria Fernanda Monteiro  Costa; Mariana Horn da Cruz; Radhija Albuquerque Rocha Cardoso; Renata Gomes Santos Guimarães; Samuel Antunes Correia Bomfim; Thiago Matheus Ribeiro Da  Silva

doi:10.36557/2674-8169.2024v6n2p633-639

Perspectives on Therapies for Parkinson's Disease: Investigating Neuroprotectors and Progression Modifiers

Authors

José Lucas Moura Vasconcelos UniFG Guanambi
Andressa Karoline Alves Leite UNIFAMAZ https://orcid.org/0009-0000-1198-8622
Anisia da Silva Teixeira UNIFACS https://orcid.org/0009-0003-6119-3264
Bárbara Dayann Rocha Barreto UNIFACS https://orcid.org/0009-0005-1823-2613
Carla Maria Zanelli Pinaty Universidade de Cuiabá - UNIC https://orcid.org/0009-0002-9480-0537
Caroline Fernanda Alexandre Henrique Universidade de Cuiabá - UNIC https://orcid.org/0009-0003-0772-3690
Dhemer Jhony Dall'Agnol Universidade de Cuiabá - UNIC https://orcid.org/0009-0000-4531-8029
Giovanna Vieira Brito Universidade de Cuiabá - UNIC https://orcid.org/0009-0004-8754-666X
Giovana Pereira Viana UNIFG Guanambi https://orcid.org/0009-0009-6870-2862
Heloísa Maria Marson Bonatti Universidade do Oeste Paulista - UNOESTE https://orcid.org/0009-0005-5035-3538
Julia Maria Prestes Capatto Universidade de Cuiabá - UNIC https://orcid.org/0009-0003-8055-7086
Kauara Marcelino Gonçalves Universidade de Cuiabá - UNIC https://orcid.org/0009-0000-2383-8744
Larissa Cunha Hipolito Rodrigues UNIFACS https://orcid.org/0009-0005-8841-3137
Luana Cruz Nunes Godinho Universidade de Cuiabá - UNIC https://orcid.org/0009-0000-3258-5849
Maria Eugênia Abílio Lima Centro Universitário FipMoc - UnifipMoc https://orcid.org/0009-0007-7982-7252
Maria Fernanda Monteiro Costa Universidade de Cuiabá - UNIC https://orcid.org/0009-0003-8928-5507
Mariana Horn da Cruz UniFOA https://orcid.org/0009-0005-8803-5308
Radhija Albuquerque Rocha Cardoso UNIFG Brumado https://orcid.org/0009-0008-6785-0081
Renata Gomes Santos Guimarães UNIFACS https://orcid.org/0009-0003-7887-5034
Samuel Antunes Correia Bomfim UNIFG Guanambi https://orcid.org/0009-0001-3385-7997
Thiago Matheus Ribeiro Da Silva Universidade de Cuiabá - UNIC https://orcid.org/0009-0001-9854-5767

DOI:

https://doi.org/10.36557/2674-8169.2024v6n2p633-639

Keywords:

Parkinson's disease

Abstract

This review addressed advances in the development of neuroprotective and progression-modifying therapies in Parkinson's disease (PD). Literature analysis highlighted the potential of therapeutic strategies based on antioxidants, gene therapy, and other innovative approaches to slow down PD progression. The results of reviewed studies suggest that these therapies show significant promise in reducing motor symptoms and preserving dopaminergic function. However, challenges such as PD heterogeneity and lack of robust biomarkers remain significant obstacles to translating these findings into effective therapies. Ongoing research and interdisciplinary collaboration are essential to drive innovation and transform these promising therapeutic perspectives into clinical reality.

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References

Schapira, A. H., Olanow, C. W., Greenamyre, J. T., & Bezard, E. (2014). Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives. The Lancet, 384(9942), 545-555.

Jenner, P., & Olanow, C. W. (2006). Understanding cell death in Parkinson's disease. Annals of Neurology, 59(3), 421-429.

Kalia, L. V., & Lang, A. E. (2015). Parkinson's disease. The Lancet, 386(9996), 896-912.

Ascherio, A., Zhang, S. M., Hernán, M. A., Kawachi, I., Colditz, G. A., Speizer, F. E., & Willett, W. C. (2001). Prospective study of caffeine consumption and risk of Parkinson's disease in men and women. Annals of Neurology, 50(1), 56-63.

Chen, H., Zhang, S. M., Hernán, M. A., Willett, W. C., Ascherio, A., & F. E. (2002). Diet and Parkinson's disease: a potential role of dairy products in men. Annals of Neurology, 52(6), 793-801.

Olanow, C. W., & Schapira, A. H. (2013). Therapeutic prospects for Parkinson disease. Annals of Neurology, 74(3), 337-347.

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Published

2024-02-06

How to Cite

Vasconcelos, J. L. M., Leite , A. K. A., Teixeira, A. da S., Barreto , B. D. R., Pinaty , C. M. Z., Henrique , C. F. A., Dall’Agnol, D. J., Brito , G. V., Viana , G. P., Bonatti , H. M. M., Capatto , J. M. P., Gonçalves , K. M., Rodrigues , L. C. H., Godinho , L. C. N., Lima , M. E. A., Costa , M. F. M., Cruz , M. H. da, Cardoso , R. A. R., Guimarães , R. G. S., Bomfim, S. A. C., & Silva , T. M. R. D. (2024). Perspectives on Therapies for Parkinson’s Disease: Investigating Neuroprotectors and Progression Modifiers. Brazilian Journal of Implantology and Health Sciences, 6(2), 633–639. https://doi.org/10.36557/2674-8169.2024v6n2p633-639

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Issue

Vol. 6 No. 2 (2024): BJIHS QUALIS B3

Section

Literature Review

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Copyright (c) 2024 José Lucas Moura Vasconcelos, Andressa Karoline Alves Leite , Anisia da Silva Teixeira, Bárbara Dayann Rocha Barreto , Carla Maria Zanelli Pinaty , Caroline Fernanda Alexandre Henrique , Dhemer Jhony Dall'Agnol, Giovanna Vieira Brito , Giovana Pereira Viana , Heloísa Maria Marson Bonatti , Julia Maria Prestes Capatto , Kauara Marcelino Gonçalves , Larissa Cunha Hipolito Rodrigues , Luana Cruz Nunes Godinho , Maria Eugênia Abílio Lima , Maria Fernanda Monteiro Costa , Mariana Horn da Cruz , Radhija Albuquerque Rocha Cardoso , Renata Gomes Santos Guimarães , Samuel Antunes Correia Bomfim, Thiago Matheus Ribeiro Da Silva