Abstract
Introduction: Neuroinflammation is characterized by an inflammatory response that occurs in the brain and spinal cord through the action of factors capable of disrupting the body's homeostasis, such as trauma, infection, ischemia and toxins. Long-term exposure to these toxins, in turn, may be related not only to the emergence of neurodegenerative diseases, but also to anxiety and depression disorders. The objective of this research was to carry out an integrative review with an emphasis on analyzing the impacts of neuroinflammation on anxiety and depression disorders. Methods: For the bibliographic survey, data were collected from the virtual libraries PubMed, LILACS and Scientific Electronic Library Online. Data collection was carried out in five stages. To systematize the search and selection of collected articles, it was necessary to use the recommendation of Preferred Reporting Items for Systematic Reviews and Meta Analyses. Results: The main results showed that increased neuroinflammatory activity is present as a component of depressive symptoms mainly in outpatients, and suggests that greater neuroinflammatory activity is related to the severity of the disease. Conclusion: Based on the data presented here, it is suggested that other studies be developed dealing with the topic, taking into account the scarcity of research and the period of transition experienced in the current context, in which many investigations are in the process of development, with a view to supply the search for strategies to cope with such biopsychosocial conditions.
References
Giallongo S, Longhitano L, Denaro S, D'Aprile S, Torrisi F, La Spina E, Giallongo C, Mannino G, Lo Furno D, Zappalà A, Giuffrida R, Parenti R, Li Volti G, Tibullo D, Vicario N. The Role of Epigenetics in Neuroinflammatory-Driven Diseases. Int J Mol Sci. 2022 Dec 2;23(23):15218. doi: 10.3390/ijms232315218. PMID: 36499544; PMCID: PMC9740629.
Teleanu DM, Niculescu AG, Lungu II, Radu CI, Vladâcenco O, Roza E, Costăchescu B, Grumezescu AM, Teleanu RI. An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases. Int J Mol Sci. 2022 May 25;23(11):5938. doi: 10.3390/ijms23115938. PMID: 35682615; PMCID: PMC9180653.
Sørensen NV, Borbye-Lorenzen N, Christensen RHB, Orlovska-Waast S, Jeppesen R, Skogstrand K, Benros ME. Comparisons of 25 cerebrospinal fluid cytokines in a case-control study of 106 patients with recent-onset depression and 106 individually matched healthy subjects. J Neuroinflammation. 2023 Apr 4;20(1):90. doi: 10.1186/s12974-023-02757-2. PMID: 37016363; PMCID: PMC10071627.
Frota, Ilgner, et al. “Anxiety Disorders: History, Clinical Features, and Current Classifications.” J. Health Biol Sci, vol. 10, no. 1, 2022, pp. 1–8, docs.bvsalud.org/biblioref/2022/03/1361739/3971.pdf, https://doi.org/10.12662/2317-3206jhbs.v10i1.3971.p1-8.2022.
ICD-11 - Mortality and Morbidity Statistics [Internet]. Who.int. 2018. Available from: https://icd.who.int/browse11/l-m/en#/http://id.who.int/icd/entity/1563440232
Frota I, Campos De Moura Fé A, Martins De Paula F, Gomes V, De Moura S, De E, et al. Anxiety disorders: history, clinical features, and current classifications. J Health Biol Sci [Internet]. 2022;10(1):1–8. Available from: https://docs.bvsalud.org/biblioref/2022/03/1361739/3971.pdf
Guo B, Zhang M, Hao W, Wang Y, Zhang T, Liu C. Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression. Transl Psychiatry. 2023 Jan 9;13(1):5. doi: 10.1038/s41398-022-02297-y. PMID: 36624089; PMCID: PMC9829236.
Ganong LH. Integrative reviews of nursing research. Res Nurs Health. 1987;10(1):1-11.
MARTINS, Everton. Conheça os principais tipos de Artigo Científico. Blog Mettzer, 2018, maio.
SOUZA, Marcela Tavares de; SILVA, MICHELLY Dias da; CARVALHO, Rachel de. Revisão integrativa: o que é e como fazer. Einstein, v. 8, n. 1, p. 102-106, 2010.
Pereira R. Enfermagem baseada na evidência: um desafio, uma oportunidade. In C. Marques-Vieira; L. Sousa (Eds). Cuidados de enfermagem de reabilitação à pessoa ao longo da vida. Loures: Lusodidata. 2017;101-111.
Mingoti MED, Bertollo AG, Simões JLB, Francisco GR, Bagatini MD, Ignácio ZM. COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route. J Mol Neurosci. 2022 Jun;72(6):1166-1181. doi: 10.1007/s12031-022-02004-y. Epub 2022 Mar 23. PMID: 35322375; PMCID: PMC8942178.
Lyra E Silva NM, Barros-Aragão FGQ, De Felice FG, Ferreira ST. Inflammation at the crossroads of COVID-19, cognitive deficits and depression. Neuropharmacology. 2022 May 15;209:109023. doi: 10.1016/j.neuropharm.2022.109023. Epub 2022 Mar 4. PMID: 35257690; PMCID: PMC8894741.
Brusaferri L, Alshelh Z, Martins D, Kim M, Weerasekera A, Housman H, Morrissey EJ, Knight PC, Castro-Blanco KA, Albrecht DS, Tseng CE, Zürcher NR, Ratai EM, Akeju O, Makary MM, Catana C, Mercaldo ND, Hadjikhani N, Veronese M, Turkheimer F, Rosen BR, Hooker JM, Loggia ML. The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic. Brain Behav Immun. 2022 May;102:89-97. doi: 10.1016/j.bbi.2022.02.018. Epub 2022 Feb 16. PMID: 35181440; PMCID: PMC8847082.
Logan LM, Stephens S, Ciftci-Kavaklioglu B, Berenbaum T, Ly M, Longoni G, Yeh EA. Pandemic-associated mental health changes in youth with neuroinflammatory disorders. Mult Scler Relat Disord. 2022 Feb;58:103468. doi: 10.1016/j.msard.2021.103468. Epub 2021 Dec 20. PMID: 34954653; PMCID: PMC9765271.
Nazarinia D, Behzadifard M, Gholampour J, Karimi R, Gholampour M. Eotaxin-1 (CCL11) in neuroinflammatory disorders and possible role in COVID-19 neurologic complications. Acta Neurol Belg. 2022 Aug;122(4):865-869. doi: 10.1007/s13760-022-01984-3. Epub 2022 Jun 12. PMID: 35690992; PMCID: PMC9188656.
Sørensen NV, Orlovska-Waast S, Jeppesen R, Klein-Petersen AW, Christensen RHB, Benros ME. Neuroinflammatory Biomarkers in Cerebrospinal Fluid From 106 Patients With Recent-Onset Depression Compared With 106 Individually Matched Healthy Control Subjects. Biol Psychiatry. 2022 Oct 1;92(7):563-572. doi: 10.1016/j.biopsych.2022.04.002. Epub 2022 Apr 10. PMID: 35659385.
Sørensen NV, Borbye-Lorenzen N, Christensen RHB, et al. Comparisons of 25 cerebrospinal fluid cytokines in a case-control study of 106 patients with recent-onset depression and 106 individually matched healthy subjects. J Neuroinflammation. 2023;20(1):90. Published 2023 Apr 4. doi: 10.1186/s12974-023-02757-2.
Groh A, Jahn K, Walter M, et al. TNF-α Increase in a Cohort of Depressive Patients. Dis Markers. 2021;2021:8897421. Published 2021 Mar 15. doi: 10.1155/2021/8897421.
Serna-Rodríguez MF, Bernal-Vega S, de la Barquera JAO, Camacho-Morales A, Pérez-Maya AA. The role of damage associated molecular pattern molecules (DAMPs) and permeability of the blood-brain barrier in depression and neuroinflammation. J Neuroimmunol. 2022 Oct 15;371:577951. doi: 10.1016/j.jneuroim.2022.577951. Epub 2022 Aug 17. PMID: 35994946.
Althubaity N, Schubert J, Martins D, Yousaf T, Nettis MA, Mondelli V, Pariante C, Harrison NA, Bullmore ET, Dima D, Turkheimer FE, Veronese M. Choroid plexus enlargement is associated with neuroinflammation and reduction of blood brain barrier permeability in depression. Neuroimage Clin. 2022;33:102926. doi: 10.1016/j.nicl.2021.102926. Epub 2021 Dec 27. PMID: 34972034; PMCID: PMC8718974.
Zhang W, Rutlin J, Eisenstein SA, et al. Neuroinflammation in the Amygdala Is Associated With Recent Depressive Symptoms. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023;8(9):967-975. doi:10.1016/j.bpsc.2023.04.011
Kinoshita H, Takekawa D, Kudo T, Sawada K, Mikami T, Hirota K. Higher neutrophil-lymphocyte ratio is associated with depressive symptoms in Japanese general male population [published correction appears in Sci Rep. 2022 Jul 11;12(1):11770]. Sci Rep. 2022;12(1):9268. Published 2022 Jun 3. doi:10.1038/s41598-022-13562-x.
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Copyright (c) 2023 Marcus Vinícius Barbosa Moreira, Giovanna Sobral Fernandes, Marcelo Barreto Mesquita de Goes, André Luís Tomaz do Nascimento, Anne Caroline d’Ávila Pinheiro Daniel, Ana Beatriz dos Santos Silva, Amanda Safira Araújo Mendes, Ana Cecília Leão de Carvalho, Ana Larissa Fernandes de Holanda Soares