Diagnosis and Treatment of Type 1 Diabetes Mellitus in Pediatrics: A Comprehensive Approach
PDF (Português (Brasil))

Keywords

Type 1 Diabetes Mellitus; Pediatrics; Continuous Monitoring.

How to Cite

Braga e Silva, A. L., Amaral Moreira , R., Fabrício de Araújo Coelho, M., de Souza Oliveira , P. M., & Ribeiro Santiago Ferreira , J. P. (2023). Diagnosis and Treatment of Type 1 Diabetes Mellitus in Pediatrics: A Comprehensive Approach . Brazilian Journal of Implantology and Health Sciences, 5(5), 4733–4748. https://doi.org/10.36557/2674-8169.2023v5n5p4733-4748

Abstract

Significant advances in the diagnosis and treatment of Type 1 Diabetes Mellitus (T1DM) in pediatric patients represent pivotal milestones in the professional realm, providing a comprehensive view of emerging therapeutic approaches. Among the discussed strategies, the crucial role of pancreas transplantation, as evidenced by recent studies, stands out. The success of this procedure in highly selected cases offers an optimistic outlook, albeit with the caveat that it should be considered as a last resort, administered in specialized centers, reinforcing the need for a judicious approach.

Additionally, the effectiveness of technological innovations such as closed-loop therapy systems, analog insulins, and automatic infusion devices is examined. Positive outcomes from these interventions indicate a significant shift in the management of T1DM in children, with substantial improvements in glycemic control and quality of life. However, the critical analysis of studies underscores the importance of considering the specific nuances of the pediatric age group in the development of therapeutic strategies.

Relevant aspects related to cutaneous reactions associated with the use of devices such as insulin pumps and glucose monitors are of paramount importance in the multidisciplinary context. By identifying the prevalence of these reactions and their implications, the urgent need for guidelines for the prevention and management of these cutaneous issues in children with T1DM is emphasized. A multidisciplinary approach, involving diabetologists, dermatologists, and other healthcare professionals, emerges as essential to ensure enhanced cutaneous tolerability and, consequently, the long-term effectiveness of treatment for this pediatric population.

Finally, the continuous importance of research and innovation in building a promising future for children facing the complexity of T1DM is underscored. The personalized approach to early diagnosis, coupled with therapeutic interventions tailored to individual needs, promotes not only clinical advancements but also a compassionate approach in managing this chronic condition in pediatric patients. The study concludes by emphasizing the ongoing need for collaboration among healthcare professionals, researchers, and the industry to drive significant advances in the field of diagnosis and treatment of T1DM in Pediatrics.

https://doi.org/10.36557/2674-8169.2023v5n5p4733-4748
PDF (Português (Brasil))

References

ALEPPO, et al. Improvements in glycemic outcomes in 4738 children, adolescents, and adults with type 1 diabetes initiating a tubeless insulin management system. Diabetes Ther, v. 14, p. 593–610, 2023.

ADAMUSIAK, et al. Effective treatment of diabetes, improved quality of life and accelerated cognitive development after pancreas transplantation in a child with type 1 diabetes and allergy to manufactured insulin preparations. Pediatric Transplantation, v. 27, p. e14447, 2023.

CARDONA-HERNANDEZ, et al. New therapies towards a better glycemic control in youths with type 1 diabetes. Pharmacological Research, v. 195, p. 106882, 2023.

DOVC, et al. A Comparison of Faster Insulin Aspart with Standard Insulin Aspart Using Hybrid Automated Insulin Delivery System in Active Children and Adolescents with Type 1 Diabetes: A Randomized Double-Blind Crossover Trial. DIABETES TECHNOLOGY & THERAPEUTICS, v. 25, n. 9, 2023.

GENÈVE, et al. High incidence of skin reactions secondary to the use of adhesives in glucose sensors or insulin pumps for the treatment of children with type 1 diabetes. Diabetes Research and Clinical Practice, v. 204, p. 110922, 2023.

HUMMEL, et al. Children diagnosed with presymptomatic type 1 diabetes through public health screening have milder diabetes at clinical manifestation. Diabetologia, v. 66, p. 1633–1642, 2023.

KANDIYALI, et al. Implementation of flash glucose monitoring in four pediatric diabetes clinics: controlled before and after study to produce real-world evidence of patient benefit. BMJ Open Diab Res Care, v. 11, p. e003561, 2023.

MARKS, et al. Monitoring of Pediatric Type 1 Diabetes. Front. Endocrinol., v. 11, p. 128, 2020.

NEU, et al. Diagnosis, Therapy and Follow-Up of Diabetes Mellitus in Children and Adolescents. Exp Clin Endocrinol Diabetes, v. 127, Suppl 1, p. S39–S72, 2019.

OCHOCIŃSKA, et al. Selected Serum Markers Associated with Pathogenesis and Clinical Course of Type 1 Diabetes in Pediatric Patients—The Effect of Disease Duration. J. Clin. Med., v. 12, p. 2151, 2023.

WARE, et al. Hybrid Closed-Loop with Faster Insulin Aspart Compared with Standard Insulin Aspart in Very Young Children with Type 1 Diabetes: A Double-Blind, Multicenter, Randomized, Crossover Study. DIABETES TECHNOLOGY & THERAPEUTICS, v. 25, n. 6, 2023.

WHERRETT, et al. Type 1 Diabetes in Children and Adolescents. Can J Diabetes, v. 42, p. S234–S246, 2018.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2023 Ana Luíza Braga e Silva, Renata Amaral Moreira , Mariana Fabrício de Araújo Coelho, Paloma Maria de Souza Oliveira , João Pedro Ribeiro Santiago Ferreira