Microbiota Intestinal e sua influência nas Infecções Hospitalares: Uma revisão de literatura

Autores

DOI:

https://doi.org/10.36557/2674-8169.2023v5n5p4412-4436

Palavras-chave:

Palavras-chave: Hospital, Infecções, Microbiota Intestinal.

Resumo

Trata-se de uma revisão de literatura científica com pesquisas efetuada nas bases de dados Google Scholar e Pubmed com o objetivo de relatar o impacto da microbiota intestinal para o paciente hospitalizado, envolvendo outros microrganismos exógenos que afetam a saúde da microbiota intestinal e o processo de saúde-doença no organismo humano.  A microbiota do trato gastrointestinal, com constituição diversa e rica em bactérias comensais, apresenta grande relação com o desenvolvimento e instalação de diversos patógenos no paciente, representando um material de imensa importância por sua ligação com diversos sistemas, como respiratório e imunológico. O ambiente hospitalar é apontado como potencial para a disseminação de infecções, situação associada à assistência em saúde, a terapia com antibióticos, processos invasivos e a condição do paciente. Conclui-se que a relação entre microbiota intestinal instável e o paciente hospitalizado configurando-se como uma problemática para o bem estar do indivíduo, esperamos que a compreensão sobre a conexão e a necessidade de uma microbiota intestinal equilibrada para o estabelecimento da homeostase do ser humano por completo, permita que esses microrganismos sejam protegidos com mais vigor por meio de tratamentos mais cuidadosos.

Downloads

Não há dados estatísticos.

Biografia do Autor

Glauber Pimentel Florêncio, Universidade Federal de Uberlândia

Mestre em Ciências da saúde pela Universidade Federal de Uberlândia.

Ralciane de Paula Menezes , Universidade Federal de Uberlândia

Técnica na Escola Técnica de Saúde (ESTES) na Universidade Federal de Uberlândia (UFU)

Denise Von Dolinger de Brito Roder , Universidade Federal de Uberlândia

Professora Adjunta na Universidade Federal de Uberlândia.

Referências

ADELMAN, Max W.; WOODWORTH, Michael H.; LANGELIER, Charles; BUSCH, Lindsay M.; KEMPKER, Jordan A.; KRAFT, Colleen S.; MARTIN, Greg S. The gut microbiome’s role in the development, maintenance, and outcomes of sepsis. Critical Care, [s. l.], v. 24, n. 1, p. 278, 2020. DOI: https://doi.org/10.1186/s13054-020-02989-1.

AGUDELO-OCHOA, Gloria M.; VALDÉS-DUQUE, Beatriz E.; GIRALDO-GIRALDO, Nubia A.; JAILLIER-RAMÍREZ, Ana M.; GIRALDO-VILLA, Adriana; ACEVEDO-CASTAÑO, Irene; YEPES-MOLINA, Mónica A.; BARBOSA-BARBOSA, Janeth; BENÍTEZ-PAÉZ, Alfonso. Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis. Gut Microbes, [s.l.], v. 12, n. 1, p. 1707610, 10 jan. 2020. DOI: http://dx.doi.org/10.1080/19490976.2019.1707610.

BADI, Sara Ahmadi; TARASHI, Samira; FATEH, Abolfazl; ROHANI, Pejman; MASOTTI, Andrea; SIADAT, Seyed Davar. From the Role of Microbiota in Gut-Lung Axis to SARS-CoV-2 Pathogenesis. Mediators Of Inflammation, [S.L.], v. 2021, p. 1-12, 16 abr. 2021. Hindawi Limited. DOI: http://dx.doi.org/10.1155/2021/6611222.

CROBACH, Monique J. T.; DUCARMON, Quinten R.; TERVEER, Elisabeth M.; HARMANUS, Celine; SANDERS, Ingrid M. J. G.; VERDUIN, Kees M.; KUIJPER, Ed J.; ZWITTINK, Romy D.. The Bacterial Gut Microbiota of Adult Patients Infected, Colonized or Noncolonized by Clostridioides difficile. Microorganisms, [S.L.], v. 8, n. 5, p. 677, 6 maio 2020. MDPI AG. DOI: http://dx.doi.org/10.3390/microorganisms8050677.

CUI, Meng-Yan; CUI, Zhen-Yu; ZHAO, Meng-Qi; ZHANG, Meng-Jie; JIANG, Qiao-Li; WANG, Jing-Jing; LU, Lun-Gen; LU, Ying-Ying. The impact of Helicobacter pylori infection and eradication therapy containing minocycline and metronidazole on intestinal microbiota. BMC Microbiology, [s. l.], v. 22, n. 1, p. 321, 2022. DOI: https://doi.org/10.1186/s12866-022-02732-6.

CZEPIEL, Jacek; DRÓŜDŜ, Mirosław; PITUCH, Hanna; KUIJPER, Ed J.; PERUCKI, William; MIELIMONKA, Aleksandra; GOLDMAN, Sarah; WULTAńSKA, Dorota; GARLICKI, Aleksander; BIESIADA, Grażyna. Clostridium difficile infection: review. European Journal Of Clinical Microbiology & Infectious Diseases, [S.L.], v. 38, n. 7, p. 1211-1221, 3 abr. 2019. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1007/s10096-019-03539-6.

GARCIA, Elisa Rubio; VERGARA, Andrea; AZIZ, Fátima; NARVÁEZ, Sofía; CUESTA, Genoveva; HERNÁNDEZ, María; TOAPANTA, David; MARCO, Francesc; FERNÁNDEZ, Javier; SORIANO, Alex. Changes in the gut microbiota and risk of colonization by multidrug-resistant bacteria, infection, and death in critical care patients. Clinical Microbiology And Infection, [S.L.], v. 28, n. 7, p. 975-982, jul. 2022. Elsevier BV. DOI: http://dx.doi.org/10.1016/j.cmi.2022.01.004.

GOMAA, Eman Zakaria. Human gut microbiota/microbiome in health and diseases: a review. Antonie van Leeuwenhoek, [s.l.], v. 113, n. 12, p. 2019-2040, 2 nov. 2020. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1007/s10482-020-01474-7.

HAAK, Bastiaan W.; PRESCOTT, Hallie C.; WIERSINGA, W. Joost. Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis. Frontiers in Immunology, [s. l.], v. 9, p. 2042, 2018. DOI: 10.3389/fimmu.2018.02042

HERNÁNDEZ, Marta; DE FRUTOS, Mónica; RODRÍGUEZ-LÁZARO, David; LÓPEZ-URRUTIA, Luis; QUIJADA, Narciso M.; EIROS, Jose M. Fecal Microbiota of Toxigenic Clostridioides difficile-Associated Diarrhea. Frontiers in Microbiology, [s. l.], v. 9, p. 3331, 2019.

DOI: https://doi.org/10.3389/fmicb.2018.03331

HOLSCHER, Hannah D. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes, [s. l.], v. 8, n. 2, p. 172–184, 2017. DOI: https://doi.org/10.1080/19490976.2017.1290756.

KERSCHNER, Heidrun; CABAL, Adriana; HARTL, Rainer.; MACHHERNDL-SPANDL, Sigrid; ALLERBERGER, Franz; RUPPITSCH, Werner; APFALTER, Petra. Hospital outbreak caused by linezolid resistant Enterococcus faecium in Upper Austria. Antimicrobial Resistance & Infection Control, [s. l.], v. 8, n. 1, p. 150, 2019. DOI: https://doi.org/10.1186/s13756-019-0598-z.

LAFATA, Giorgio; WEBER, Peter; MOHAJERI, M. Hasan. Probiotics and the Gut Immune System: indirect regulation. Probiotics And Antimicrobial Proteins, [s.l.], v. 10, n. 1, p. 11-21, 31 ago. 2017. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1007/s12602-017-9322-6.

LEVAST, Benoit; BENECH, Nicolas; GASC, Cyrielle; BATAILLER, Cécile; SENNEVILLE, Eric; LUSTIG, Sébastien; POUDEROUX, Cécile; BOUTOILLE, David; BOUCINHA, Lilia; DAUCHY, Frederic-Antoine; ZELLER, Valérie; MAYNARD, Marianne; CAZANAVE, Charles; LE THI, Thanh-Thuy; JOSSE, Jérôme; DORÉ, Joel; LAURENT, Frederic; FERRY, Tristan. Impact on the Gut Microbiota of Intensive and Prolonged Antimicrobial Therapy in Patients With Bone and Joint Infection. Frontiers in Medicine, [s. l.], v. 8, p. 586875, 2021. DOI: https://doi.org/10.3389/fmed.2021.586875.

LI, Shaoshuai; ZHOU, Yang; YAN, Dongmei; WAN, Yanmin. An Update on the Mutual Impact between SARS-CoV-2 Infection and Gut Microbiota. Viruses, [S.L.], v. 14, n. 8, p. 1774, 15 ago. 2022. MDPI AG. DOI: http://dx.doi.org/10.3390/v14081774.

LIU, Qin; MAK, Joyce W. Y.; SU, Qi; YEOH, Y. Kit; LUI, Grace C.-Y.; NG, Shan S. S.; ZHANG, Fen; LI, Amy Y. L.; LU, Wenqi; HUI, David S.-C.; CHAN, Paul K.; CHAN, Francis K. L.; NG, Siew C. Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome. Gut, [s. l.], v. 71, n. 3, p. 544–552, 2022.

DOI: http://dx.doi.org/10.1136/gutjnl-2021-325989

MAEDA, Yuichi; MOTOOKA, Daisuke; KAWASAKI, Takahiro; OKI, Hiroya; NODA, Yoshimi; ADACHI, Yuichi; NIITSU, Takayuki; OKAMOTO, Shota; TANAKA, Kentaro; FUKUSHIMA, Kiyoharu; AMIYA, Saori; HARA, Reina; OGURO-IGASHIRA, Eri; MATSUKI, Takanori; HIRATA, Haruhiko; TAKEDA, Yoshito; KIDA, Hiroshi; KUMANOGOH, Atsushi; NAKAMURA, Shota; TAKEDA, Kiyoshi. Longitudinal alterations of the gut mycobiota and microbiota on COVID-19 severity. BMC Infectious Diseases, [s. l.], v. 22, n. 1, p. 572, 2022.

DOI: https://doi.org/10.1186/s12879-022-07358-7.

MUSTANSIR DAWOODBHOY, Fatema; PATEL, Bharati K.; PATEL, Kadamb; BHATIA, Madhav; LEE, Chuen N.; MOOCHHALA, Shabbir M. Gut Microbiota Dysbiosis as a Target for Improved Post-Surgical Outcomes and Improved Patient Care: A Review of Current Literature. Shock, [s. l.], v. 55, n. 4, p. 441–454, 2021. DOI: 10.1097/SHK.0000000000001654

NAVIDINIA, Masoumeh; GOUDARZI, Mehdi. Overview Perspective of Bacterial Strategies of Resistance to Biocides and Antibiotics. Archives of Clinical Infectious Diseases, [s. l.], v. In Press, n. In Press, 2019. Disponível em: https://brieflands.com/articles/archcid-65744.html. DOI: https://doi.org/10.5812/archcid.65744.

NEGRUT, Nicoleta; BUNGAU, Simona; BEHL, Tapan; KHAN, Shamim Ahmad; VESA, Cosmin Mihai; BUSTEA, Cristiana; NISTOR-CSEPPENTO, Delia Carmen; RUS, Marius; PAVEL, Flavia-Maria; TIT, Delia Mirela. Risk Factors Associated with Recurrent Clostridioides difficile Infection. Healthcare, [S.L.], v. 8, n. 3, p. 352, 21 set. 2020. MDPI AG. DOI: http://dx.doi.org/10.3390/healthcare8030352.

NG, Siew C; A KAMM, Michael; YEOH, Yun Kit; CHAN, Paul K s; ZUO, Tao; TANG, Whitney; SOOD, Ajit; ANDOH, Akira; OHMIYA, Naoki; ZHOU, Yongjian. Scientific frontiers in faecal microbiota transplantation: joint document of asia-pacific association of gastroenterology (apage) and asia-pacific society for digestive endoscopy (apsde). Gut, [S.L.], v. 69, n. 1, p. 83-91, 14 out. 2019. BMJ. DOI: http://dx.doi.org/10.1136/gutjnl-2019-319407.

OLIPHANT, Kaitlyn; ALLEN-VERCOE, Emma. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome, [s. l.], v. 7, n. 1, p. 91, 2019. DOI:https://doi.org/10.1186/s40168-019-0704-8 .

PILMIS, Benoit; MONNIER, Alban Le; ZAHAR, Jean-Ralph. Gut Microbiota, Antibiotic Therapy and Antimicrobial Resistance: a narrative review. Microorganisms, [S.L.], v. 8, n. 2, p. 269, 17 fev. 2020. MDPI AG. DOI: http://dx.doi.org/10.3390/microorganisms8020269.

PRISMA. Transparent Reporting of Systematic Reviews and Meta-Analyses. 2023. Disponível em: http://www.prisma-statement.org/Default.aspx.

PORTINCASA, Piero; BONFRATE, Leonilde; VACCA, Mirco; ANGELIS, Maria de; FARELLA, Ilaria; LANZA, Elisa; KHALIL, Mohamad; WANG, David Q.-H.; SPERANDIO, Markus; CIAULA, Agostino di. Gut Microbiota and Short Chain Fatty Acids: implications in glucose homeostasis. International Journal Of Molecular Sciences, [S.L.], v. 23, n. 3, p. 1105, 20 jan. 2022. MDPI AG. DOI:

http://dx.doi.org/10.3390/ijms23031105.

RAMOS, Sónia; SILVA, Vanessa; DAPKEVICIUS, Maria; IGREJAS, Gilberto; POETA, Patrícia. Enterococci, from Harmless Bacteria to a Pathogen. Microorganisms, [S.L.], v. 8, n. 8, p. 1118, 25 jul. 2020. MDPI AG. DOI: http://dx.doi.org/10.3390/microorganisms8081118.

SENDER, Ron; FUCHS, Shai; MILO, Ron. Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans. Cell, [S.L.], v.164, n.3, p. 337-340, 28 jan. 2016. DOI: https://doi.org/10.1016/j.cell.2016.01.013

SIRANOSIAN, Benjamin A.; BROOKS, Erin F.; ANDERMANN, Tessa; REZVANI, Andrew R.; BANAEI, Niaz; TANG, Hua; BHATT, Ami S. Rare transmission of commensal and pathogenic bacteria in the gut microbiome of hospitalized adults. Nature Communications, [s. l.], v. 13, n. 1, p. 586, 2022. DOI: https://doi.org/10.1038/s41467-022-28048-7.

SCHLECHTE, Jared; ZUCOLOTO, Amanda Z.; YU, Ian-Ling; DOIG, Christopher J.; DUNBAR, Mary J.; MCCOY, Kathy D.; MCDONALD, Braedon. Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections. Nature Medicine, [S.L.], v. 29, n. 4, p. 1017-1027, 9 mar. 2023. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1038/s41591-023-02243-5.

SCHMITT, Felix C. F.; BRENNER, Thorsten; UHLE, Florian; LOESCH, Svenja; HACKERT, Thilo; ULRICH, Alexis; HOFER, Stefan; DALPKE, Alexander H.; WEIGAND, Markus A.; BOUTIN, Sébastien. Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery. BMC Microbiology, [s. l.], v. 19, n. 1, p. 42, 2019.

DOI: https://doi.org/10.1186/s12866-019-1399-5

SHAH, Taif; BALOCH, Zulqarnain; SHAH, Zahir; CUI, Xiuming; XIA, Xueshan. The Intestinal Microbiota: impacts of antibiotics therapy, colonization resistance, and diseases. International Journal Of Molecular Sciences, [S.L.], v. 22, n. 12, p. 6597, 20 jun. 2021. DOI: http://dx.doi.org/10.3390/ijms22126597.

SHIN, Jae Hyun; WARREN, Cirle A.. Prevention and treatment of recurrent Clostridioides difficile infection. Current Opinion In Infectious Diseases, [S.L.], v. 32, n. 5, p. 482-489, out. 2019. Ovid Technologies (Wolters Kluwer Health). DOI: http://dx.doi.org/10.1097/qco.0000000000000587.

SONG, Jung Hoon; KIM, You Sun. RecurrentClostridium difficileInfection: risk factors, treatment, and prevention. Gut And Liver, [S.L.], v. 13, n. 1, p. 16-24, 15 jan. 2019. The Editorial Office of Gut and Liver. DOI: http://dx.doi.org/10.5009/gnl18071.

SZYCHOWIAK, Piotr ; VILLAGEOIS-TRAN, Khanh; PATRIER, Juliette; TIMSIT, Jean-François; RUPPÉ, Étienne.The role of the microbiota in the management of intensive care patients. Annals of Intensive Care, [s. l.], v. 12, n. 1, p. 3, 2022. DOI: https://doi.org/10.1186/s13613-021-00976-5.

TAMBURINI, Fiona B.; ANDERMANN, Tessa M.; TKACHENKO, Ekaterina; SENCHYNA, Fiona; BANAEI, Niaz; BHATT, Ami S.. Precision identification of diverse bloodstream pathogens in the gut microbiome. Nature Medicine, [S.L.], v. 24, n. 12, p. 1809-1814, 15 out. 2018. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1038/s41591-018-0202-8.

TAN, Glorijoy Shi En; TAY, Hui Lin; TAN, Sock Hoon; LEE, Tau Hong; NG, Tat Ming; LYE, David Chien. Gut Microbiota Modulation: implications for infection control and antimicrobial stewardship. Advances In Therapy, [S.L.], v. 37, n. 10, p. 4054-4067, 7 ago. 2020. Springer Science and Business Media LLC. DOI: http://dx.doi.org/10.1007/s12325-020-01458-z.

VENTERO, María Paz; ESPINOSA, Noelia; JOVER, Rodrigo; GUILLEN, Yolanda; MERINO, Esperanza; RODRÍGUEZ, Juan Carlos. Evolution of intestinal microbiome in a process of faecal microbiota transplantation in a patient with Clostridioides difficile infection: ngs analysis with different bioinformatics software programs. Enfermedades Infecciosas y Microbiologia Clinica (English Ed.), [S.L.], v. 39, n. 4, p. 184-187, abr. 2021. Elsevier BV. DOI: http://dx.doi.org/10.1016/j.eimce.2021.02.001.

XIA, Xiong; NI, Jiangjin; YIN, Shengnan; YANG, Zhipeng; JIANG, Hain; WANG, Chao; PENG, Jeng; WEI, Hongkui; WANG, Xingyu. Elevated Systemic and Intestinal Inflammatory Response Are Associated With Gut Microbiome Disorder After Cardiovascular Surgery. Frontiers in Microbiology, [s. l.], v. 12, p. 686648, 2021. DOI: https://doi.org/10.3389/fmicb.2021.686648.

XUE, Ling; DING, Yinglong; QIN, Qiong; LIU, Linsheng; DING, Xiaoling; ZHOU, Yi; LIU, Kun; SINGLA, Rajeev K.; SHEN, Ke; DIN, Ahmad U.; ZHANG, Yan; SHEN, Zhenya; SHEN, Bairong; MIAO, Liyan. Assessment of the impact of intravenous antibiotics treatment on gut microbiota in patients: Clinical data from pre-and post-cardiac surgery. Frontiers in Cellular and Infection Microbiology, [s. l.], v. 12, p. 1043971, 2023.

DOI: https://doi.org/10.3389/fcimb.2022.1043971.

WANG, Chenyang; LI, Qiurong; REN, Jianan. Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection. Frontiers in Immunology, [s. l.], v. 10, p. 1873, 2019.

DOI: https://doi.org/10.3389/fimmu.2019.01873

WANG, Daosheng; DONG, Danfeng ; WANG, Chen ; CUI, Yingchao ; JIANG, Cen; NI, Qi; SU, Tongxuan; WANG, Guanzheng; MAO, Enqianq; PENG, Yibing. Risk factors and intestinal microbiota: Clostridioides difficile infection in patients receiving enteral nutrition at Intensive Care Units. Critical Care, [s. l.], v. 24, n. 1, p. 426, 2020. DOI: https://doi.org/10.1186/s13054-020-03119-7 .

WIEËRS, Grégoire; VERBELEN, Valérie; VAN DEN DRIESSCHE, Mieke; MELNIK, Ekaterina; VANHEULE, Greet; MAROT, Jena-Christophe; CANI, Patrice D. Do Probiotics During In-Hospital Antibiotic Treatment Prevent Colonization of Gut Microbiota With Multi-Drug-Resistant Bacteria? A Randomized Placebo-Controlled Trial Comparing Saccharomyces to a Mixture of Lactobacillus, Bifidobacterium, and Saccharomyces. Frontiers in Public Health, [s. l.], v. 8, p. 578089, 2021.

DOI: https://doi.org/10.3389/fpubh.2020.578089.

WUETHRICH, Irene; W. PELZER, Benedikt; KHODAMORADI, Yascha; VEHRESCHILD, Maria J. G. T. The role of the human gut microbiota in colonization and infection with multidrug-resistant bacteria. Gut Microbes, [s. l.], v. 13, n. 1, p. 1911279, 2021. DOI: https://doi.org/10.1080/19490976.2021.1911279

Downloads

Publicado

2023-12-02

Como Citar

Onofre, M. J., Florêncio, G. P., Menezes , R. . de P., & Roder , D. V. D. de B. (2023). Microbiota Intestinal e sua influência nas Infecções Hospitalares: Uma revisão de literatura . Brazilian Journal of Implantology and Health Sciences, 5(5), 4412–4436. https://doi.org/10.36557/2674-8169.2023v5n5p4412-4436

Edição

Seção

Revisão de Literatura