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O artigo possui como objetivo expor os principais biomarcadores de sepse pediátrica e apontar suas vantagens no prognóstico dos afetados e como objetivo secundários, demonstrar o Modelo de Risco de Biomarcadores de Sepse Pediátrica (PERSEVERE). Trata-se de uma revisão narrativa de caráter crítico e analítico, na pesquisa sobre os principais conceitos no que tange os biomarcadores de sepse pediátrica. Foi realizada uma revisão de artigos nas bases de dados Scientific Electronic Library Online (SciELO) e PubMed, com os seguintes Descritores em Ciências da Saúde (DeCS): Biomarcadores; Pediatria; Sepse. A mortalidade associada à sepse permanece um desafio significativo para a saúde pública infantil global. Estimar de forma confiável o risco basal de mortalidade em casos de sepse pediátrica representa uma forma importante de enriquecimento prognóstico. O enriquecimento prognóstico é essencial para diversas áreas, incluindo a tomada de decisões clínicas, a alocação eficiente de recursos, os esforços para melhoria da qualidade do atendimento e a pesquisa. Embora diversos biomarcadores tenham sido avaliados para estimar o risco de desfechos desfavoráveis em sepse, poucos foram validados com rigor suficiente para serem adotados clinicamente como estratégias eficazes de enriquecimento prognóstico. O uso de biomarcadores para identificar pacientes com sepse continua sendo uma área de pesquisa amplamente reconhecida e de grande importância. No entanto, uma vertente igualmente relevante, embora menos enfatizada, é a descoberta e o desenvolvimento de biomarcadores voltados para o enriquecimento prognóstico e preditivo em pacientes com sepse. Nos últimos anos, essa área tem avançado significativamente, especialmente no contexto pediátrico.
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Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 Luiz Felipe Neves Frazão, Isadora Ribeiro Schettert, Luca Moreira Mansur Zambaldi, Gabriel Ramos Muniz Braga , Ana Beatriz Martins de Lima , Mateus dos Santos Ribeiro , Sthefan Bruno Machado Ribeiro, Felipe de Figueiredo Zaccara, Bárbara Helena Bernardes Cabral, Murilo Zupelli Rodrigues Alves
