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Abstract
The article aims to present the main biomarkers of pediatric sepsis and highlight their advantages in predicting outcomes for affected patients. As a secondary objective, it aims to demonstrate the Pediatric Sepsis Biomarker Risk Model (PERSEVERE). This is a narrative review with a critical and analytical approach, focusing on the key concepts related to pediatric sepsis biomarkers. A review of articles was conducted using the Scientific Electronic Library Online (SciELO) and PubMed databases, with the following Health Sciences Descriptors (DeCS): Biomarkers, Pediatrics, Sepsis. Mortality associated with sepsis remains a significant challenge for global pediatric public health. Reliably estimating the baseline risk of mortality in pediatric sepsis cases is an important form of prognostic enrichment. Prognostic enrichment is crucial for various areas, including clinical decision-making, efficient resource allocation, efforts to improve care quality, and research. Although several biomarkers have been evaluated to estimate the risk of adverse outcomes in sepsis, few have been rigorously validated to be adopted clinically as effective strategies for prognostic enrichment. The use of biomarkers to identify sepsis patients continues to be a widely recognized and important area of research. However, an equally relevant, albeit less emphasized, aspect is the discovery and development of biomarkers aimed at prognostic and predictive enrichment in sepsis patients. In recent years, this area has advanced significantly, especially in the pediatric context.
References
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Copyright (c) 2025 Luiz Felipe Neves Frazão, Isadora Ribeiro Schettert, Luca Moreira Mansur Zambaldi, Gabriel Ramos Muniz Braga , Ana Beatriz Martins de Lima , Mateus dos Santos Ribeiro , Sthefan Bruno Machado Ribeiro, Felipe de Figueiredo Zaccara, Bárbara Helena Bernardes Cabral, Murilo Zupelli Rodrigues Alves
