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Abstract
The gut microbiota primarily consists of prokaryotic microorganisms, playing a pivotal role in influencing the host's nutrient metabolism, regulating the immune system against infectious agents, and affecting the nervous system. So, we propose a narrative literature review aiming to discuss the importance of gut microbiota supplementation with micronutrients.Omega-3 polyunsaturated fatty acids (PUFAs) modulate it by influencing the type and abundance of intestinal microorganisms, altering levels of pro-inflammatory mediators, and regulating short-chain fatty acid levels or their salts. Vitamin D, synthesized through skin exposure to ultraviolet B rays, has shown changes in the gut microbiota after supplementation (e.g., increased Enterobacteriaceae) and remained unchanged in HIV positive individuals. Vitamin C significantly influences the microbiota, being absorbed in the proximal small intestine, and its supplementation increases essential bacteria like Lachnospiraceae and Blautia. Vitamin A, involved in multiple physiological processes, regulated the gut microbiota upon supplementation by increasing bacteria like Bifidobacterium, Bacteroidetes, and Prevotella. Vitamin B12 supplementation, solely sourced from animal-derived foods, also shifted the microbiota, raising the abundance of Bacteroidetes and Firmicutes. Based on the analyzed studies, various factors influence the role of micronutrients in the gut microbiota, including lifestyle habits, diet, region and country, nutritional status, and the presence of chronic diseases.
References
Rinninella E, Cintoni M, Raoul P, Lopetuso LR, Scaldaferri F, Pulcini G, et al. Food Components and Dietary Habits: Keys for a Healthy Gut Microbiota Composition. Nutrients.2019; 11: 2392.
Al Bander Z, NitertM,Mousa A, NaderpoorN.The Gut Microbiota and Inflammation: An Overview. International journal of environmental research and public health. 2020; 17(20): 7618.
Cuffato B, Assohoun A, Boutillier D, Peucelle V, Desramaut J, Boudebbouze S, et al. Identification of New Potential Biotherapeutics from Human Gut Microbiota-Derived Bacteria. Microorganisms. 2021; 9(3):565.
Mascarenhas G, Salles P, Do Amaral MM. The impact of gut microbiota on sleep quality: An integrative review. Brazilian Journal of Development. 2021; 7(7):70985-70998.
Skrypnik K, Suliburska J. Association between the gut microbiota and mineral metabolism. Journal of the science of food and agriculture.2018; 98: 2449-2460.
Iddir M, Brito A, Dingeo G, Fernandez Del Campo SS, Samouda H, La Frano MR, et al. Bohn T. Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients.2020;12:1562.
Maggini S, Pierre A, Calder PC.Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients.2018; 10(10): 1531.
Fu Y, Wang Y, Gao H, Li D, Jiang R, Ge L, et al. Associations among Dietary Omega-3 Polyunsaturated Fatty Acids, the Gut Microbiota, and Intestinal Immunity. Mediators Inflamm.2021; 2021.
Constantini L, Molinari R, Farinon B, Merendino N. Impact of Omega-3 Fatty Acids on the Gut Microbiota. International Journal of Molecular Sciences.2017; 18: 2645.
Watson H, Mitra S, Croden FC, Taylor M, Wood HM, Perry SL, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut.2018; 67:1974-1983
Younge N, Yang Q, Seed PC. Enteral High Fat-Polyunsaturated Fatty Acid Blend Alters the Pathogen Composition of the Intestinal Microbiome in Premature Infants with an Enterostomy. J Pediatr.2017; 181:93-101.
Bellerba F, Muzio V, Gnagnarella P, Facciotti F, Chiocca S, Bossi P, et al. The AssociationbetweenVitamin D andGutMicrobiota: A Systematic Review ofHumanStudies. Nutrients. 2021; 13(10): 3378.
Garg M, Hendy P, NikDing J, Shaw S, Hold G, Hart A, et al. The EffectofVitamin D on Intestinal InflammationandFaecalMicrobiota in PatientswithUlcerativeColitis.JournalofCrohn'sandColitis. 2018; 12(8): 963–972
Schäffler H, Herlemann D.P, Klinitzke P, Berlin P, Kreikemeyer B, Jaster R, et al. Vitamin D administration leads to a shift ofthe intestinal bacterialcomposition in Crohn'sdiseasepatients, butnot in healthycontrols. JournalofDigestiveDiseases.2018; 19(9): 225-234
Kanhere M, He J, Chassaing B, R Ziegler T, A Alvarez J, A Ivie E, et al. Bolus Weekly Vitamin D3SupplementationImpactsGutandAirway Microbiota in AdultsWithCysticFibrosis: A Double-Blind, Randomized, Placebo-ControlledClinical Trial. The JournalofClinicalEndocrinology&Metabolism. 2018; 103(2):564-574
Drall K M, Field C J, Haqq A M, de Souza R J, Tun H M, Morales-Lizcano N P, et al. Vitamin D supplementation in pregnancyandearlyinfancy in relationtogutmicrobiotacompositionandC. difficilecolonization: implications for viral respiratoryinfections. GutMicrobes. 2020; 12(1)
Missailidis C, Sorensen N, Ashenafi S, Amogne W, Kassa E, Bekele A, et al. Vitamin D andPhenylbutyrateSupplementation Does NotModulateGutDerivedImmuneActivation in HIV-1. Nutrients. 2019; 11(7): 1675
Wong S K, Chin K Y, Ima-Nirwana S. Vitamin C: A Review onits Role in the Management ofMetabolicSyndrome. Int J Med Sci. 2020; 17(11): 1625-1638
Otten A T, Bourgonje A R, Peters V, Alizadeh B Z, Dijkstra G, Harmsen H. Vitamin C Supplementation in HealthyIndividuals Leads to Shifts ofBacterialPopulations in theGut—A PilotStudy.Antioxidants. 2021; 10(8): 1278
Liu X, Mao B, Gu J, Wu J, Cui S, Wang G, et al. Blautia—a new functional genus withpotentialprobioticproperties? GutMicrobes.2021; 13(1): 1-21
Li L, Krause L, Somerset S. Associationsbetweenmicronutrientintakesandgutmicrobiota in a groupofadultswithcysticfibrosis. Clinicalnutrition (Edinburgh, Scotland). 2017; 36(4): 1097-1104
Stojanov S, Berlec A, Štrukelj B.The InfluenceofProbioticsontheFirmicutes/BacteroidetesRatio in theTreatmentofObesityandInflammatoryBoweldisease.Microorganisms.2020; 8(11): 1715
Debelo H, Novotny J A, Ferruzzi M G. Vitamin A. Advances in nutrition (Bethesda, Md.). 2017; 8(6): 992-994
Carazo A, Macáková K, Matoušová K, Krčmová L K, Protti M, Mladěnka P. Vitamin A Update: Forms, Sources, Kinetics, Detection, Function, Deficiency, Therapeutic Use andToxicity . Nutrients. 2021; 13(5): 1703
Liu J, Liu X, Xiong X Q, Yang T, Cui T, Hou N L, et al. Effectofvitamin A supplementationongutmicrobiota in childrenwithautismspectrumdisorders - a pilotstudy.BMCmicrobiology. 2017; 17(1): 204
Thomas F, Hehemann J H, Rebuffet E, Czjzek M, Michel G. Environmental andgutbacteroidetes: the food connection. Frontiers in microbiology.2011; 2:93
Koliada A, Syzenko G, Moseiko V, Budovska L, Puchkov K, Perederiy V, et al. Associationbetween body mass index andFirmicutes/Bacteroidetesratio in anadultUkrainianpopulation. BMC microbiology. 2017; 17(1): 120
Kerckhoffs A P, Samsom M, van der Rest M E, de Vogel J, Knol J, Ben-Amor K, et al. Lower Bifidobacteriacounts in both duodenal mucosa-associatedand fecal microbiotain irritablebowelsyndromepatients. World journalofgastroenterology. 2009; 15(23): 2887-2892
Huda M N, Ahmad S M, Kalanetra K M, Taft D H, Alam M J, Khanam A, et al. Neonatal Vitamin A SupplementationandVitamin A Status Are Associated withGutMicrobiomeComposition in BangladeshiInfants in Early Infancyandat 2 Years of Age. The Journalofnutrition. 2019; 149(6): 1075-1088
Putnam E E, Goodman A L. B vitaminacquisitionbygutcommensalbacteria. PLoSpathogens. 2020; 16(1): e1008208
Hasbaoui B E, Mebrouk N, Saghir S, Yajouri A E, Abilkassem R, Agadr A. Vitamin B12 deficiency: case reportand review ofliterature.The Pan African medical journal. 2021; 38: 237.
Arendt J, Horváth-Puhó E, Sorensen H T, Nexo E, Pedersen L, Ording A G, et al. Plasma Vitamin B12 Levels, High-Dose Vitamin B12 Treatment, and Risk ofDementia. JournalofAlzheimer'sdisease : JAD. 2021; 79(4): 1601–1612.
Xu Y, Xiang S, Ye K, Zheng Y, Feng X, Zhu X, et al. Cobalamin (Vitamin B12) Induced a Shift in Microbial CompositionandMetabolicActivity in aninvitroColonSimulation. Frontiers in microbiology. 2018; 9:2780
Zheng Y, Xiang S, Zhang H, Ye K, Zhang Y, Ge Y, et al. Vitamin B12 Enriched in Spinachand its EffectsonGutMicrobiota. Journalofagriculturaland food chemistry. 2021; 69(7): 2204–2212.
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Copyright (c) 2023 Amanda Viana Hortêncio, Brenda de Souza Marques, Denise vonDolinger de Brito Röder, Ralciane de Paula Menezes