Whipple Surgery: Indications and Techniques.
PDF (Português (Brasil))

Keywords

Pancreaticoduodenectomy, Surgical Indications, and Surgical Techniques

How to Cite

Ferreira, G. M., Oliveira, G. G. R., Fernandes, F. F., Ferreira, F. M., Ferreira Neto, P. P. M., França, H. V. de, Cunha, R. R. de O., Pereira, G. de O., Abdala, G. F. de S. S., de Paula, I. G., Gonçalves, E. A., Rocha, T. G., Alves, I. T., & Arias, V. N. (2023). Whipple Surgery: Indications and Techniques. Brazilian Journal of Implantology and Health Sciences, 5(5), 1604–1615. https://doi.org/10.36557/2674-8169.2023v5n5p1604-1615

Abstract

We explore Whipple surgery, a complex surgical intervention used to treat pancreatic tumors and periampullary conditions. We discuss its history, surgical techniques, improvements and evolution over the years. We address the complications associated with Whipple surgery, including pancreatic fistulas, hemorrhages, anastomotic strictures and postoperative infections, highlighting the importance of prevention and adequate management of these complications. We explore adjuvant treatment, such as chemotherapy, which aims to reduce the risk of pancreatic cancer recurrence after surgery. We discuss palliative care as a fundamental part of treatment for patients with advanced or metastatic stages of pancreatic cancer, emphasizing the importance of relieving symptoms, improving quality of life, and providing emotional and social support. We address the need for a personalized approach to treating pancreatic cancer, taking into account the stage of the disease and the individual needs of the patient. We conclude that treating pancreatic cancer is a multifaceted challenge, and the combination of surgery, adjuvant treatment and palliative care plays a crucial role in improving quality of life and increasing the chances of therapeutic success for patients.

https://doi.org/10.36557/2674-8169.2023v5n5p1604-1615
PDF (Português (Brasil))

References

American Cancer Society. (2020). Key Statistics for Pancreatic Cancer. Disponível em: https://www.cancer.org/cancer/pancreatic-cancer/about/key-statistics.html

Bakitas, M. A., Tosteson, T. D., Li, Z., et al. (2015). Early Versus Delayed Initiation of Concurrent Palliative Oncology Care: Patient Outcomes in the ENABLE III Randomized Controlled Trial. Journal of Clinical Oncology, 33(13), 1438-1445.

Bassi, C., Dervenis, C., Butturini, G., et al. (2005). Postoperative pancreatic fistula: An international study group (ISGPF) definition. Surgery, 138(1), 8-13.

Bilimoria, K. Y., Bentrem, D. J., Wayne, J. D., et al. (2007). Small bowel obstruction after pancreaticoduodenectomy: a population-based analysis. Annals of Surgery, 245(5), 800-807.

Cameron, J. L., Riall, T. S., Coleman, J., Belcher, K. A. (2007). One thousand consecutive pancreaticoduodenectomies. Annals of Surgery, 244(1), 10-15.

Kawabata, Y., Tanaka, T., Nitta, N., et al. (2019). Percutaneous transhepatic cholangioscopic balloon dilation for anastomotic stricture after pancreaticoduodenectomy. World Journal of Gastroenterology, 25(33), 4872-4882.

Maisonneuve, P., & Lowenfels, A. B. (2015). Risk factors for pancreatic cancer: a summary review of meta-analytical studies. International Journal of Epidemiology, 44(1), 186-198.

McMillan, M. T., Allegrini, V., Asbun, H. J., et al. (2015). Incorporation of procedure-specific risk in the ACS-NSQIP Surgical Risk Calculator improves the prediction of morbidity and mortality after pancreatoduodenectomy. HPB, 17(11), 978-984.

Neoptolemos, J. P., Kleeff, J., Michl, P., & Costello, E. (2017). Pancreatic cancer. The Lancet, 391(10125), 1307-1323.

Oettle, H., Neuhaus, P., Hochhaus, A., et al. (2013). Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA, 310(14), 1473-1481.

Temel, J. S., Greer, J. A., Muzikansky, A., et al. (2010). Early palliative care for patients with metastatic non-small-cell lung cancer. New England Journal of Medicine, 363(8), 733-742.

Whipple, A. O. (1935). A reminiscence of the concept of pancreaticoduodenectomy. American Journal of Surgery, 67(2), 216-222.

Yeo, C. J., Cameron, J. L., Sohn, T. A., et al. (2000). Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Annals of Surgery, 232(3), 273-279.

Zureikat, A. H., Beane, J. D., Zenati, M., et al. (2019). 500 Minimally Invasive Robotic Pancreatoduodenectomies: One Decade of Optimizing Performance. Annals of Surgery, 269(1), 113-119.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright (c) 2023 Gabriela Milhomem Ferreira, Gabriel Gonçalves Rezende Oliveira, Fernanda Furtado Fernandes, Fernanda Mendonça Ferreira, Pedro Paulo Martins Ferreira Neto, Hiago Vinícius de França, Renan Rodrigues de Oliveira Cunha, Gabriel de Oliveira Pereira, Guilherme Fontes de Sousa Skaf Abdala, Isadora Garcia de Paula, Eduarda Arantes Gonçalves, Taís Garcia Rocha, Isabella Tavares Alves, Valesca Naciff Arias