COVID-19 AND MATERNAL FETAL COMPLICATIONS: A LITERATURE REVIEW
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Keywords

COVID-19
Maternal-fetal complications
Pregnant women

How to Cite

Freire, M. D., Rocha, A. A. da, Souza, F. T. de, Lima, T. B., & Guimarães, A. de O. (2023). COVID-19 AND MATERNAL FETAL COMPLICATIONS: A LITERATURE REVIEW. Brazilian Journal of Implantology and Health Sciences, 5(4), 2169–2186. https://doi.org/10.36557/2674-8169.2023v5n4p2169-2186

Abstract

SARS-CoV-2 is a single-chain virus, responsible for causing an infectious disease with high transmission power, which can affect multiple organs and systems. Given the pandemic scenario, groups vulnerable to infection began to be identified, such as pregnant women, due to their immunological and physiological changes, presenting a greater susceptibility to the manifestation of the disease in its most severe form and a greater risk of obstetric and perinatal complications. For this study, an integrative literature review was used with a search on the platforms PubMed®, BIREME, LILACS, SciELO, and IBECS, for articles published between 2019 and 2023, with the descriptors "SARS-COV-2”; “COVID-19”; "PREGNANT"; “FETAL”; “COMPLICATIONS” and Boolean operator “AND”. 187 articles were found, and 25 publications constituted the final sample, with articles outside the proposed period or that did not present a direct correlation with the topic being disregarded. According to in the studies covered, most pregnant women infected by SARS-CoV-2 presented a mild condition, although the need for intensive support was also highlighted in order to cause outcomes such as premature birth, cesarean sections, hypertensive disorders, thromboembolic complications, lower weight at birth and premature rupture of membranes. Fetal receptors were found both in the placental tissue and also in fetal tissues, suggesting the possible occurrence of vertical transmission, and possible damage to fetal development. It is therefore concluded that COVID-19 infection can cause several losses in the maternal-fetal binomial, although its impact is not yet completely clarified in the literature. In view of this, further studies are necessary in order to better assess these consequences and the real long-term commitment.

https://doi.org/10.36557/2674-8169.2023v5n4p2169-2186
PDF (Português (Brasil))

References

Wang CL, liu YY, Wu CH, Wang CY, Wang CH, Long CY. Impact of COVID-19 on Pregnancy. International Journal of Medical Sciences. 2021;18(3):763–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797535/ doi: 10.7150/ijms .49923

Bastos SNMAN, Barbosa BLF, Cruz LGB, Souza RP de, Silva Melo SS e, Luz CCB da S. Clinical and Obstetric Aspects of Pregnant Women with COVID-19: A Systematic Review. Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics. 2021 Dec;43(12):949–60. Available from: https://www.scielo.br/j/rbgo/ a/VMskJMgx5vXJTRYQsJg8H6n/?lang=en doi: 10.105 5/s-0041-1733913

Gonçalves DR, Andrade A, Dias J, Moreira M, Braga A, Ferreira L, et al. COVID-19 and Pregnancy. When are complications expected? Nascer e Crescer [Internet]. 2022 Sep 1 [cited 2023 Jul 22];31(3):304–9. Available from: http://www.scielo.pt/scielo.p hp?script=sci_arttext&pid=S0872-075420220003003 04&lang=pt doi: 10.257 53/birthgrowthmj.v31.i3.27741

Mirbeyk M, Saghazadeh A, Rezaei N. A systematic review of pregnant women with COVID-19 and their neonates. Archives of Gynecology and Obstetrics. 2021 Apr 2;304(1):5–38. Available from: https://pubmed.ncbi.nlm.nih.gov/33797605/ doi: 10.1007/s00404-021-06049-z

Granja MG, Oliveira AC da R, Figueiredo CS de, Gomes AP, Ferreira EC, Giestal-de-Araujo E, et al. SARS-CoV-2 Infection in Pregnant Women: Neuroimmune-Endocrine Changes at the Maternal-Fetal Interface. Neuroimmunomodulation [Internet]. 2021 [cited 2021 Oct 1];28(1):1–21. Available from: https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC8247841/ doi: 10.1159/000515556

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine. 2020 Jan 24;382(8). Available from: https://pubmed.ncbi.nlm.nih.gov/31978945/ doi: 10.105 6/NEJMoa2001017

Carvalho BC de, Kloppel LN, Vieira RC. Infecção por COVID-19 na gestação. Femina [Internet]. 2022;308–10. Available from: https://docs.bvsalud.org/biblioref/2022/0 8/1380710/femina-2022-505-308-310.pdf

WHO Coronavirus (COVID-19) Dashboard [Internet]. covid19.who.int. Available from: https://covid19.who.int/?mapFilter=cases

Comprehensive analysis of COVID-19 during pregnancy. Biochemical and Biophysical Research Communications [Internet]. 2021 Jan 29;538:180–6. Available from: https://www.sciencedirect.com/science/article/pii/S0006291X20322415?via %3Dihub doi: 10.1016/j.bbrc.2020.12.064

Elsaddig M, Khalil A. Effects of the COVID pandemic on pregnancy outcomes. Best Practice & Research Clinical Obstetrics & Gynaecology. 2021 Mar;73. Available from: https://pubmed.ncbi.nlm.nih.gov/33832868/ doi: 10.1016/j.bpobgyn.2021.03.004

Salma U. Relationship of COVID-19 with pregnancy. Taiwanese Journal of Obstetrics and Gynecology. 2021 May;60(3):405–11. Available from: https://www.sciencedire ct.com/science/article/pii/S1028455921000565?via%3Dihub doi: 10.1016/j.tjog.20 21.03.005

Santos MJDM dos, Pimentel TL, Catharina ND, Castro TRA, Soares KF. Análise dos desfechos maternos e fetais relacionados à COVID-19 durante a gestação. Femina [Internet]. 2022;379–84. Available from: https://docs.bvsalud.org/biblioref/2023/0 3/1380722/femina-2022-506-379-384.pdf

Ferrer-Oliveras R, Mendoza M, Capote S, Pratcorona L, Esteve-Valverde E, Cabero-Roura L, et al. Immunological and physiopathological approach of COVID-19 in pregnancy. Archives of Gynecology and Obstetrics. 2021 May 4. Available from: https://pubmed.ncbi.nlm.nih.gov/33945026/ doi: 10.1007/s00404-021-06061-3

Wastnedge EAN, Reynolds RM, van Boeckel SR, Stock SJ, Denison FC, Maybin JA, et al. Pregnancy and COVID-19. Physiological Reviews [Internet]. 2021 Jan 1;101(1):303–18. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 7686875/ doi: 10.1152/physrev.00024.2020

Furlan MCR, Jurado SR, Uliana CH, Silva MEP da, Nagata LA, Maia ACF. Gravidez e infecção por Coronavírus: desfechos maternos, fetais e neonatais – Revisão sistemática. Revista Cuidarte [Internet]. 2020 Aug 1 [cited 2021 Jun 21];11(2). Available from: https://revistas.udes.edu.co/cuidarte/article/view/1211/1574 doi: 10.15649/cuidarte.1211

Muñoz Taya R, Campos Del Castillo K, Coronado Arroyo JC, Huerta Sáenz IH. SARS-CoV-2 en la segunda mitad del embarazo: resultados materno – perinatales. Revista Peruana de Ginecología y Obstetricia. 2020 Nov 7;66(3). Available from: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S2304-513220200003 00004&lang=pt doi: 10.31403/rpgo.v66i2273

Godoi APN, Bernardes GCS, Almeida NA de, Melo SN de, Belo VS, Nogueira LS, et al. Síndrome Respiratória Aguda Grave em gestantes e puérperas portadoras da COVID-19. Revista Brasileira de Saúde Materno Infantil [Internet]. 2021 Jun 30;21:461–9. Available from: https://www.scielo.br/j/rbsmi/a/X95wpXnpqVcVDtY WQrskYxy/?lang=pt doi: 10.1590/1806-9304202100S200008

Metz TD, Clifton RG, Hughes BL, Sandoval G, Saade GR, Grobman WA, et al. Disease Severity and Perinatal Outcomes of Pregnant Patients With Coronavirus Disease 2019 (COVID-19). Obstetrics & Gynecology [Internet]. 2021 Feb 8;Publish Ahead of Print. Available from: https://journals.lww.com/greenjournal/Fulltext/2021/04000/ Disease_Severity_and_Perinatal_Outcomes_of.3.aspx doi: 10.1097/AOG.00000000 00004339

Godoi APN, Bernardes GCS, Nogueira LS, Alpoim PN, Pinheiro M de B. Clinical Features and Maternal-fetal Results of Pregnant Women in COVID-19 Times. Revista Brasileira de Ginecologia e Obstetrícia [Internet]. 2021 Jul 30 [cited 2021 Oct 31];43:384–94. Available from: https://www.thieme-connect.de/products/ejournal s/abstract/10.1055/s-0041-1729145 doi: 10.1055/s-0041-1729145

Martinez-Perez O, Prats Rodriguez P, Muner Hernandez M, Encinas Pardilla MB, Perez Perez N, Vila Hernandez MR, et al. The association between SARS-CoV-2 infection and preterm delivery: a prospective study with a multivariable analysis. BMC Pregnancy and Childbirth. 2021 Apr 1;21(1). Available from: https://pubmed.n cbi.nlm.nih.gov/33794829/ doi: 10.1186/s12884-021-03742-4

Vega-Gonzáles EO, Arnao-Degollar V, García-Cajaleón J, Vega-Gonzáles EO, Arnao-Degollar V, García-Cajaleón J. Complicaciones en embarazadas con diagnóstico positivo de COVID-19. Ginecología y obstetricia de México [Internet]. 2021 [cited 2023 Mar 17];89(11):857–64. Available from: https://www.scielo.org.mx/scielo.p hp?script=sci_arttext&pid=S0300-90412021001100003&lang=es doi: 10.24245/g om.v89i11.6805

Barja-Ore J, Valverde-Espinoza N, Campomanes-Pelaez E, Alaya Rodríguez N, Sánchez Garavito E, Silva Ramos J, et al. Características epidemiológicas y complicaciones obstétricas en gestantes con diagnóstico de COVID-19 en un hospital público. Revista Cubana de Medicina Militar [Internet]. 2021 Dec 1 [cited 2023 Sep 14];50(4). Available from: http://scielo.sld.cu/scielo.php?script=sci_arttex t&pid=S0138-65572021000400016&lang=pt%201/9

Verma S, Joshi CS, Silverstein RB, He M, Carter EB, Mysorekar IU. SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system. Med. 2021 May;2(5):575-590.e5. Available from: https://doi.org/10.1016/j.medj.2021.04.009 doi: 10.1016/j.medj.2021.04.009

Servante J, Swallow G, Thornton JG, Myers B, Munireddy S, Malinowski AK, et al. Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis. BMC Pregnancy and Childbirth. 2021 Feb 5;21(1). Available from: https://pubmed.ncbi.nlm.nih.gov/33546624/ doi:10.1 186/s12884-021-03568-0

Valdespino‐Vázquez MY, Helguera‐Repetto CA, León‐Juárez M, Villavicencio‐Carrisoza O, Flores‐Pliego A, Moreno‐Verduzco ER, et al. Fetal and placental infection with SARS‐CoV‐2 in early pregnancy. Journal of Medical Virology. 2021 Apr 6;93(7):4480–7. Available from: https://pubmed.ncbi.nlm.nih.gov/33764543/ doi: 10.1002/jmv.26965

Faure‐Bardon V, Isnard P, Roux N, Leruez‐Ville M, Molina T, Bessieres B, et al. Protein expression of angiotensin‐converting enzyme 2, a SARS‐CoV‐2‐specific receptor, in fetal and placental tissues throughout gestation: new insight for perinatal counseling. Ultrasound in Obstetrics & Gynecology [Internet]. 2021 Feb 1 [cited 2022 Sep 19];57(2):242–7. Available from: https://www.ncbi.nlm.nih.gov/pmc/artic les/PMC7461228/ doi: 10.1002/uog.22178

Barcelos IDES, Penna IA de A, Soligo A de G, Costa ZB, Martins WP. Vertical Transmission of SARS-CoV-2: A Systematic Review. Revista Brasileira de Ginecologia e Obstetrícia / RBGO Gynecology and Obstetrics. 2021 Mar;43(03):207–15. Available from: https://www.scielo.br/j/rbgo/a/tpM9LK3vmDvGXVyn6XRxL9t/?lan g=en doi: 10.1055/s-0040-1722256

Organization, W.H. [Internet]. 2022. Available from: https://docs.bvsalud.org/biblio ref/2022/09/1393163/who-2019-ncov-clinical-20222-eng.pdf

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Copyright (c) 2023 Marina Dantas Freire, Alana Anjos da Rocha, Fabrícia Teixeira de Souza, Thayná Bezerra Lima, Adriana de Oliveira Guimarães