CARDIAC NEOPLASMS: PREVALENCE AND EARLY DIAGNOSIS
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Keywords

Cardiac neoplasm; Cardiac tumor; Sarcoma

How to Cite

Teixeira Souza, B., Dardengo Gava , F., Souza Sant’Anna , G., Zigoni de Oliveira Ribeiro , G., Silva Filho, G., Pinon Guarnier, M. C., Pereira dos Santos , H., Machado Benevides, L., Castelioni Trés Mendes , J., & Bruneli Gallina , B. (2025). CARDIAC NEOPLASMS: PREVALENCE AND EARLY DIAGNOSIS. Brazilian Journal of Implantology and Health Sciences, 7(1), 1551–1576. https://doi.org/10.36557/2674-8169.2025v7n1p1551-1576

Abstract

INTRODUCTION: Primary cardiac tumors are rare neoplasms with high mortality rates that originate within the heart itself, mainly affecting young women. They are difficult to evaluate scientifically due to the vital function of the heart and the potential for serious health problems. These tumors can be benign or malignant, with primary types including myxomas, fibromas and sarcomas, and secondary types originating from other parts of the body. Sarcomas are the primary malignant cardiac tumors with a high mortality rate compared to benign tumors, with sarcomas being the most common type. QUESTION: In this sense, the guiding question of the research arises: does knowing the prevalence of cardiac neoplasms as well as their primary and secondary subtypes make it possible to promote a better prognosis for the patient? HYPOTHESIS: A detailed understanding of the different subgroups of cardiac tumors is essential to create effective therapies and improve patient prognoses, since accurate diagnosis is crucial for effective treatment and patient care, since results and treatment approaches vary greatly depending on the type of tumor. OBJECTIVE: To evaluate the prevalence of benign and malignant primary cardiac neoplasms as a way to increase knowledge about their subtypes, effective diagnostic methods, and better prognosis and treatment. METHODOLOGY: An exploratory, cross-sectional study was conducted through a literature review in the following databases: Scientific Electronic Library Online (SciELO) and Pubmed. The following descriptors were used: Sarcoma, Cardiac neoplasms, and Cardiac tumors, in English and Portuguese. RESULTS: The main results were that malignant tumors are more prevalent than benign tumors, with sarcoma being the most common. The main diagnostic tools include imaging techniques such as echocardiography, magnetic resonance imaging, and computed tomography, which provide detailed information about the size, location, and nature of the tumor. CONCLUSIONS: Computed Magnetic Resonance Imaging was the most assertive method for identifying the type of neoplasm. Biopsy is a histopathological analysis necessary to confirm the diagnosis and identify the type of tumor. Early detection and accurate diagnosis are vital to prevent complications and improve survival rates, making advances in diagnostic methods an important focus in cardiac oncology research. RECOMMENDATIONS: It is suggested that a meta-analysis be performed to evaluate the main tumor subtypes and age groups of involvement.

https://doi.org/10.36557/2674-8169.2025v7n1p1551-1576
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References

Abraham, K.P.; Reddy, V.; Gattuso, P. Neoplasms metastatic to the heart: review 3314 consecutive autopsies. Am. J. Cardiovasc. Pathol. 1999. 3: 195-198.

Anderson, C.M.; Pusztai, L.; Palmer, J.L. et al. Coincident renal cell carcinoma and the lymphoma: the M.D. Anderson experience and review of literature. J Urol. 1998. 159:714-717.

Butz, T.; Faber, L.; Langer, C. et al. Primary malignant pericardial mesothelioma - a rare cause of pericardial effusion and consecutive constrictive pericarditis: a case report. J. Med. Case Reports. 2009; 3:9256.

Camachoa, Á.F.; Hernándeza, F.H.; Bodesa, R.S.; Péreza, I.S.; Porrasb, A.C.; Péreza, J.T. Linfoma cardíaco primario: diagnóstico mediante biopsia transyugular. Revista Española de Cardiología. 2003. 56 (11): 1141-1144.

Chambergo-Michilot, Diego et al. “Clinical characteristics, management, and outcomes of patients with primary cardiac angiosarcoma: A systematic review.” Journal of cardiovascular and thoracic research 15,1 (2023): 1-8. doi:10.34172/jcvtr.2023.30531

Ceresoli, G.L.; Ferreri, A.; Bucci, E.; Ripa, C.; Ponzoni, M.; Villa, E. Primary cardiac lymphoma in inmunocompetent patients. Diagnostic and therapeutic management. Cancer. 1997. 80: 1497-506.

DENG, Hai-Wei et al. “Incidence of chemotherapy-related cardiac dysfunction in cancer patients.” Clinical cardiology. 47,4 (2024): e24269. doi:10.1002/clc.24269

Fussen, S.; De Boeck, B.W.; Zellweger, M.J.; et al. Cardiovascular magnetic resonance imaging for diagnosis and clinical management of suspected cardiac masses and tumours. Eur. Heart J. 2011; 32: 1551-60.

Giusca, S.; Mereles, D.; Ochs, A. et al. Incremental value of cardiac magnetic resonance for the evaluation of cardiac tumors in adults: experience of a high volume tertiary cardiology centre. Int. J. Cardiovasc. Imaging. 2017. 33: 879-88.

Hudzik, B.; Miszalski-Jamka, K.; Glowacki, J.; Lekston, A.; Gierlotka, M.; Zembala, M.; Polonski, L.; Gasior, M. Malignant tumors of the heart. Cancer Epidemiology. 2015. 39 (5). 665-672.

Kainuma, S.; Masai, T.; Yamauchi T. et al. Primary malignant pericardial mesothelioma presenting as pericardial constriction. Ann. Thorac. Cardiovasc. Surg. 2008. 14:396-8.

Kassi, M.; Polsani, V.; Schutt, R.C. et al. Differentiating benign from malignant cardiac tumors with cardiac magnetic resonance imaging. J. Thorac. Cardiovasc. Surg. 2019.157:1912-1922.e2.

Lemasle, M.; Lavie, B. Y.; Cariou, E. et al. Contribution and performance of multimodal imaging in the diagnosis and management of cardiac masses. Int. J. Cardiovasc. Imaging. 2020. 36:971-81.

Martin, M.L. Pericardial diseases. In: Braunwald E, editor. Heart disease: A textbook of cardiovascular medicine. Philadelphia: WB Saunders. 2008. p. 1830---52.

Nambiar, C.A.; Tareif, H.E.; Kishore, K.U. et al. Primary pericardial mesothelioma: one-year event-free survival. Am. Heart J. 1992. 124:802-3.

Nilsson, A.; Rasmuson, T. Primary pericardial mesothelioma: report of a patient and literature review. Case Rep Oncol. 2009. 2:125-32.

Nóbrega S, Martins Da Costa C, Amador AF, Justo S, Martins E. Cardiovascular Magnetic Resonance Versus Histopathologic Study for Diagnosis of Benign and Malignant Cardiac Tumours: A Systematic Review and Meta-Analysis. J Cardiovasc Imaging. 2023 Oct;31(4):159-168. doi: 10.4250/jcvi.2023.0028. PMID: 37901993; PMCID: PMC10622638.

Oktaviono, Yudi Her et al. “Clinical characteristics and surgical outcomes of cardiac myxoma: A meta-analysis of worldwide experience.” European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology vol. 50,2 (2024): 107940. doi:10.1016/j.ejso.2023.107940

Porcar, R.C.; Clemente, G.C.; García Parés, D.; Guardia, S.R.; Pérez, A.M.; García-Bragado, D.F. Linfoma cardíaco primario: diagnóstico citológico y tratamiento con respuesta a poliquimioterapia y autotrasplante de precursores hematopoyéticos. Presentación de un caso y revisión de la literatura. Na. Med. Interna. 2002. 19: 305-9.

Ramos, V.; Vieira, C.; Fernandes, N.; Gonçalves, F. N.; Salgado, A.; Correia, A. Causa rara de doença pericárdica. Revista Portuguesa de Cardiologia. 2013. 32(2): 149-152.

Reynen, K.; Kockeritz, U.; Strasser, R.H. Metastases to the Heart. Ann. Oncol. 2004. 15:375-38

Severino, D.; Santos, B.; Costa, C.; Durão, D.; Alves, M.; Monteiro, I.; Pitta, L.; Leal, M. Linfoma primário do coração em doente com neoplasia renal síncrona. Revista Portuguesa de Cardiologia. 2015. 34. (12): 713-798.

Suman, S.; Schofield, P.; Large, S.; et al. Primary pericardial mesothelioma presenting as pericardial constriction: a case report. Heart. 2004. 90:e4.

Vaporciyan, A.; Reardon, M. J. Sarcomas do coração direito Archive of Methodist DeBakey Cardiovascular Journal. 2010. 6 (3), 44-48.

Zhu, D.; Yin, S.; Cheng, W. et al. Cardiac MRI-based multi-modality imaging in clinical decision-making: preliminary assessment of a management algorithm for patients with suspected cardiac mass. Int. J. Cardiol. 2016. 203:474-81.

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Copyright (c) 2025 Bianca Teixeira Souza, Fernanda Dardengo Gava , Gusthavo Souza Sant'Anna , Gustavo Zigoni de Oliveira Ribeiro , Gilson Silva Filho, Maria Clara Pinon Guarnier, Heloína Pereira dos Santos , Luma Machado Benevides, Julia Castelioni Trés Mendes , Bernardo Bruneli Gallina

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