Epigenetic Factors in Autism Spectrum Disorder: Interactions Between Genetics, Environment, and Neurodevelopment

Authors

  • Ana Paula Jorge Gonçalves de Oliveira Universidade Estácio de Sá (UNESA)
  • Zoraia Cajueiro de Oliveira Centro Universitário Metropolitano da Amazônia (UNIFAMAZ)
  • Nathan Borges Marretto Universidade Nove de Julho (UNINOVE)
  • Fernanda Moura Prado Cassara Universidade Nove de Julho (UNINOVE)
  • Brenno Franco Silva da Costa Instituto de Educação Médica (IDOMED)
  • Luiz Eduardo Okada Barbosa Centro Universitário de Várzea Grande (UNIVAG)
  • Stephano Rodrigo Silva Xavier Centro Universitário do Estado do Pará (CESUPA)
  • Cezar Ernani Mancini Centro Universitário de Valença (UNIFAA)
  • Daniel Nassau de Araujo Centro Universitário de Valença (UNIFAA)
  • Tayana da Silva Moura Garcia Centro Universitário de Valença (UNIFAA)
  • Arthur Schneider de Almeida Universidade de Vila Velha (UVV)
  • Mariana Luísa da Silva Azevedo Universidade do Oeste Paulista (UNOESTE)

DOI:

https://doi.org/10.36557/2674-8169.2025v7n1p1041-1048

Keywords:

Transtorno do Espectro Autista, Epigenética, Metilação do DNA, Fatores Ambientais, Neurodesenvolvimento.

Abstract

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by deficits in social interaction, communication difficulties, and repetitive and restricted behaviors. Recent studies suggest that, in addition to genetic factors, epigenetic mechanisms — such as DNA methylation, histone modifications, and non-coding RNA — play essential roles in regulating gene expression related to brain development. These mechanisms are often influenced by environmental factors, including exposure to chemicals, maternal nutrition, stress, and infections during pregnancy. The integration of genetic predisposition, epigenetic changes, and environmental influences may explain the clinical heterogeneity observed in ASD. Research indicates that approaches based on epigenetic signatures hold promise for refining diagnostics, identifying novel therapeutic targets, and personalizing clinical interventions. Therefore, a deeper understanding of these interactions is crucial for developing more effective strategies for early diagnosis and therapeutic management of ASD.

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References

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Published

2025-01-13

How to Cite

Jorge Gonçalves de Oliveira, A. P., Cajueiro de Oliveira, Z., Borges Marretto, N., Moura Prado Cassara , F., Franco Silva da Costa, B., Okada Barbosa, L. E., Rodrigo Silva Xavier, S., Ernani Mancini, C., Nassau de Araujo, D., da Silva Moura Garcia , T., Schneider de Almeida, A., & da Silva Azevedo, M. L. (2025). Epigenetic Factors in Autism Spectrum Disorder: Interactions Between Genetics, Environment, and Neurodevelopment. Brazilian Journal of Implantology and Health Sciences, 7(1), 1041–1048. https://doi.org/10.36557/2674-8169.2025v7n1p1041-1048

Issue

Vol. 7 No. 1 (2025): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807 - ÍNDICE H 22

Section

Systematic Review

License

Copyright (c) 2025 Ana Paula Jorge Gonçalves de Oliveira, Zoraia Cajueiro de Oliveira, Nathan Borges Marretto, Fernanda Moura Prado Cassara , Brenno Franco Silva da Costa, Luiz Eduardo Okada Barbosa, Stephano Rodrigo Silva Xavier, Cezar Ernani Mancini, Daniel Nassau de Araujo, Tayana da Silva Moura Garcia , Arthur Schneider de Almeida, Mariana Luísa da Silva Azevedo

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