Ação Terapêutica dos Inibidores do Transportador 2 de Sódio-Glicose na Insuficiência Cardíaca Congestiva: Uma Revisão Integrativa
DOI:
https://doi.org/10.36557/2674-8169.2025v7n1p105-113Keywords:
Cardiomiopatias; Insuficiência cardíaca; Insuficiência Cardíaca Congestiva; Ecocardiograma., Cardiologia, Inibidores do Transportador 2 de Sódio-Glicose, dapagliflozina, tratamento, medicina, Insuficiência cardíacaAbstract
Heart failure is a clinical syndrome in which the heart is unable to pump blood adequately to meet the body's demands, resulting from structural or functional cardiac alterations, manifested by symptoms and signs resulting from reduced cardiac output and/or increased filling pressures, both at rest and during exercise. Most cases are associated with low cardiac output, but conditions such as anemia, thyrotoxicosis, arteriovenous fistulas, and beriberi can lead to high-output HF. This article is an integrative bibliographical research, with a descriptive and explanatory nature. To conduct the study, the following guiding question was defined: "What is the Therapeutic Action of Sodium-Glucose Transporter 2 Inhibitors in Congestive Heart Failure?". The literature search was performed by surveying scientific productions, using databases available in the Virtual Health Library (VHL): Latin American and Caribbean Literature in Health Sciences (LILACS) and USA National Library of Medicine (MEDLINE/PubMed). Only publications in the form of scientific articles were considered. In this context, studies have indicated that dapagliflozin is effective and well tolerated, including in combination with diuretics such as furosemide, improving symptoms without the need for dose adjustments. Another substudy revealed that 27% of patients hospitalized for acute heart failure met the criteria for dapagliflozin use, with favorable results in reducing cardiovascular mortality and readmissions. Thus, it is concluded that the studies presented reinforce the relevance of sodium-glucose cotransporter type 2 inhibitors (SGLT2i), such as dapagliflozin and sotagliflozin, in the management of heart failure. Dapagliflozin has demonstrated significant benefits in patients with reduced ejection fraction, including reduced cardiovascular mortality, hospitalizations, and improvement of symptoms, even in combination with diuretics.
Keywords: Congestive Heart Failure, Treatment, Sodium-Glucose Transporter 2 Inhibitors.
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Copyright (c) 2025 Nataly Maria Bezerra de Luna, Talita Queiroz Ferraz, Katryene Rochelly de Oliveira Cunha, Flávia Luana Lopes Tenório, Antonio Claudio Rocha Mesquita Formiga, Ana Maria Marinho Diniz, Tatiane Rairene de Moraes Costa, Letícia de Figueiredo Tavares, Daniel Galdino de Araújo Pereira, Mariana Cabral Menezes Domingues, Kelner Araújo de Vasconcelos, Matheus Augusto Albuquerque Costa
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