Keywords
SARS-CoV-2
Acometimento
Frequência
Sistema Orgânico Humano
Bibliometria
How to Cite
Abstract
INTRODUCTION: COVID-19 is a zoonotic virus disease that has had its origin in Wuhan in December 2019. Its early symptom was the occurrence of harsh abrupt cases of pneumonia. Nevertheless, the SARS-CoV-2 infection results also in a wide variety of extra pulmonary pathological manifestations, causing repercussions on the most variables biological systems. OBJECTIVES: Considering the disease’s influence and increased international dissemination, which implicates both human and socioeconomic damages linked to its expressive clinical and systematic reach; this study aims at developing a bibliometric analysis that measures the systems of the human body affected by the disease through searching of the most cited articles on the literature. MATERIAL AND METHOD: It was compiled, through Web of Science (WoS) Core Collection’s database, the most cited articles in English that described the consequences of the disease on the human body systems, both general and specifically, according to selected keywords in English. Then, it was investigated the terms linked to each system in association with its respective organs through a bibliometric analysis, except the ones that were not correlated to the COVID-19. Lastly, graphics were elaborated to provide, quantitively, the occurrence of disease implications in each system affected. RESULTS: A systematic quantitative relation made by the bibliometric technique was developed from the survey of these terms, which resulted, in addition to the most cited system and disposed in descending order: the respiratory (24,20%), cardiovascular (22,92%), nervous/sensory (15,53%), urinary (11,29%) digestive (10,52%), lymphatic/immune (8,13%), locomotor (2,89%), endocrine (2,38%), integumentary (1,62%) and, the reproductive system (0,47%). CONCLUSION: Among the systems that constitute the human organic system, its degree of involvement by COVID-19, in descending order, corresponds to the respiratory, cardiovascular, nervous/sensory, urinary, digestive, lymphatic/imune, locomotor, endocrine, integumentary and reproductive systems. Each one of these systems has its peculiarities related to the pathophysiology and symptomatology of the COVID-19 infection, which, thus, presentes itself as a multisystemic disease that affects, distinctively, each one of the human body systems.
References
Wang MY, Zhao R, Gao LJ, Gao XF, Wang DP, Cao JM. SARS-CoV-2: structure, biology, and structure-based therapeutics development. Frontiers in cellular and infection microbiology. 2020:724.
Huang Y, Yang C, Xu XF, Xu W, Liu SW. Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19. Acta Pharmacologica Sinica. 2020 Sep;41(9):1141-9.
Hu T, Liu Y, Zhao M, Zhuang Q,
Xu L, He Q. A comparison of COVID-19, SARS and MERS. PeerJ. 2020 Aug 19;8:e9725.
Li MY, Li L, Zhang Y, Wang XS. Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues. Infectious diseases of poverty. 2020 Apr 1;9(02):23-9.
União das Nações Sul-Americanas [homepage na internet]. Organização Mundial de Saúde pandemia do novo Coronavírus [acesso em 13 abr. 2023]. Disponível em: https://www.unasus.gov.br/noticia/organizacao-mundial-de-saude-declara-pandemia-de-novo-coronavirus
Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC. Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. The Lancet Infectious Diseases. 2022 Sep 1;22(9):1293-302.
Johns Hopkins University [homepage na internet]. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU) [acesso em 2 abr. 2023]. Disponível em: https://www.arcgis.com/apps/dashboards/bda7594740fd40299423467b48e9ecf6.
Silva I, Faria NC, Ferreira ÁR, Anastácio LR, Ferreira LG. Risk factors for critical illness and death among adult Brazilians with COVID-19. Revista da Sociedade Brasileira de Medicina Tropical. 2021 Apr 28;54.
Mayo Clinic [homepage na internet]. COVID-19: Who’s at higher risk of serious symptoms? [acesso em 13 abr. 2023]; Disponível em: https://www.mayoclinic.org/di seases-conditions/coronavirus/in-depth/coronavirus-who-is-at-risk/art-20483301.
Jothimani D, Venugopal R, Abedin MF, Kaliamoorthy I, Rela M. COVID-19 and the liver. Journal of hepatology. 2020 Nov 1;73(5):1231-40.
Yang X, Yu Y, Xu J, Shu H, Liu H, Wu Y, Zhang L, Yu Z, Fang M, Yu T, Wang Y. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. The Lancet Respiratory Medicine. 2020 May 1;8(5):475-81.
Cheng Y, Luo R, Wang K, Zhang M, Wang Z, Dong L, Li J, Yao Y, Ge S, Xu G. Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney international. 2020 May 1;97(5):829-38.
Pereira M, Oliveira AM. Poverty and food insecurity may increase as the threat of COVID-19 spreads. Public health nutrition. 2020 Dec;23(17):3236-40.
Neves JA, Machado ML, OLIVEIRA LD, MORENO YM, MEDEIROS MA, VASCONCELOS FD. Unemployment, poverty, and hunger in Brazil in Covid-19 pandemic times. Revista de Nutrição. 2021
Brasil. Ministério da Saúde, Conselho Nacional de Saúde. Resolução N° 510/16. Brasília; 2016
El Mohadab M, Bouikhalene B, Safi S. Bibliometric method for mapping the state of the art of scientific production in Covid-19. Chaos, Solitons & Fractals. 2020 Oct 1;139:110052.
Gavriatopoulou M, Korompoki E, Fotiou D, Ntanasis-Stathopoulos I, Psaltopoulou T, Kastritis E, Terpos E, Dimopoulos MA. Organ-specific manifestations of COVID-19 infection. Clinical and experimental medicine. 2020 Nov;20:493-506.
Gupta A, Madhavan MV, Sehgal K, Nair N, Mahajan S, Sehrawat TS, Bikdeli B, Ahluwalia N, Ausiello JC, Wan EY, Freedberg DE. Extrapulmonary manifestations of COVID-19. Nature medicine. 2020 Jul;26(7):1017-32.
Li X, Ma X. Acute respiratory failure in COVID-19: is it “typical” ARDS?. Critical care. 2020 May 6;24(1):198.
Buja LM, Wolf DA, Zhao B, Akkanti B, McDonald M, Lelenwa L, Reilly N, Ottaviani G, Elghetany MT, Trujillo DO, Aisenberg GM. The emerging spectrum of cardiopulmonary pathology of the coronavirus disease 2019 (COVID-19): report of 3 autopsies from Houston, Texas, and review of autopsy findings from other United States cities. Cardiovascular Pathology. 2020 Sep 1;48:107233.
Pons S, Fodil S, Azoulay E, Zafrani L. The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection. Critical care. 2020 Dec;24(1):1-8.
Azevedo RB, Botelho BG, Hollanda JV, Ferreira LV, Junqueira de Andrade LZ, Oei SS, Mello TD, Muxfeldt ES. Covid-19 and the cardiovascular system: a comprehensive review. Journal of human hypertension. 2021 Jan;35(1):4-11.
Dong M, Zhang J, Ma X, Tan J, Chen L, Liu S, Xin Y, Zhuang L. ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19. Biomedicine & Pharmacotherapy. 2020 Nov 1;131:110678.
Behzad S, Aghaghazvini L, Radmard AR, Gholamrezanezhad A. Extrapulmonary manifestations of COVID-19: radiologic and clinical overview. Clinical imaging. 2020 Oct 1;66:35-41.
Ramos-Casals M, Brito-Zerón P, Mariette X. Systemic and organ-specific immune-related manifestations of COVID-19. Nature Reviews Rheumatology. 2021 Jun;17(6):315-32.
Bourgonje AR, Abdulle AE, Timens W, Hillebrands JL, Navis GJ, Gordijn SJ, Bolling MC, Dijkstra G, Voors AA, Osterhaus AD, van Der Voort PH. Angiotensin‐converting enzyme 2 (ACE2), SARS‐CoV‐2 and the pathophysiology of coronavirus disease 2019 (COVID‐19). The Journal of pathology. 2020 Jul;251(3):228-48.
Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V. Pathophysiology of COVID-19-associated acute kidney injury. Nature Reviews Nephrology. 2021 Nov;17(11):751-64.
Ahmadian E, Hosseiniyan Khatibi SM, Razi Soofiyani S, Abediazar S, Shoja MM, Ardalan M, Zununi Vahed S. Covid‐19 and kidney injury: Pathophysiology and molecular mechanisms. Reviews in medical virology. 2021 May;31(3):e2176.
Villapol S. Gastrointestinal symptoms associated with COVID-19: impact on the gut microbiome. Translational Research. 2020 Dec 1;226:57-69.
Nalbandian A, Sehgal K, Gupta A, Madhavan MV, McGroder C, Stevens JS, Cook JR, Nordvig AS, Shalev D, Sehrawat TS, Ahluwalia N. Post-acute COVID-19 syndrome. Nature medicine. 2021 Apr;27(4):601-15.
Groff D, Sun A, Ssentongo AE, Ba DM, Parsons N, Poudel GR, Lekoubou A, Oh JS, Ericson JE, Ssentongo P, Chinchilli VM. Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review. JAMA network oen. 2021 Oct 1;4(10):e2128568-.
Ayres JS. A metabolic handbook for the COVID-19 pandemic. Nature metabolism. 2020 Jul;2(7):572-85.
Ramos-Casals M, Brito-Zerón P, Mariette X. Systemic and organ-specific immune-related manifestations of COVID-19. Nature Reviews Rheumatology. 2021 Jun;17(6):315-32.
Baig AM, Sanders EC. Potential neuroinvasive pathways of SARS‐CoV‐2: Deciphering the spectrum of neurological deficit seen in coronavirus disease‐2019 (COVID‐19). Journal of medical virology. 2020 Oct;92(10):1845-57.
Ahmad I, Rathore FA. Neurological manifestations and complications of COVID-19: A literature review. Journal of clinical neuroscience. 2020 Jul 1;77:8-12.
Yang L, Liu S, Liu J, Zhang Z, Wan X, Huang B, Chen Y, Zhang Y. COVID-19: immunopathogenesis and Immunotherapeutics. Signal transduction and targeted therapy. 2020 Jul 25;5(1):128.
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Copyright (c) 2023 Vinicius de Castro Dellamura, Fernando Batigalia, Adilia Maria Pires Sciarra
