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Introduction: Complex Regional Pain Syndrome (CRPS) is a complex medical condition characterized by pain that is disproportionate to the initial injury. It is divided into CRPS-I (without detectable nerve damage) and CRPS-II (with peripheral nerve damage). Objective: To examine pain management techniques in CRPS, both pharmacological and non-pharmacological, evaluating their effectiveness in improving patients' quality of life. Methodology: A literature review was conducted using databases such as PubMed, Scopus, and Web of Science, focusing on peer-reviewed studies from the last ten years. Treatments were categorized into pharmacological treatments, nerve block techniques, physical and occupational therapies, psychological therapies, and electrical stimulation methods. Results: The incidence of CRPS varies between 5 and 26 per 100,000 people annually, with higher prevalence in postmenopausal women. NSAIDs and corticosteroids are commonly used but have limited effectiveness. Bisphosphonates and free radical scavengers have shown potential. Non-pharmacological therapies, such as physiotherapy and occupational therapy, in conjunction with electrical stimulation techniques like TENS, significantly improve functionality. Discussion: A multidisciplinary approach is crucial for managing CRPS. Pharmacological therapies offer limited relief and should be combined with physical and psychological treatments to maximize benefits. Cognitive-behavioral therapy and electrical stimulation techniques are promising. Conclusion: Managing CRPS requires a comprehensive and personalized approach. More clinical studies are needed to establish clear and effective guidelines, thereby improving clinical outcomes and the quality of life of patients.
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