Apert Syndrome: Dermatological Strategies and Treatments in Children.

Abstract

Introduction: The genetic condition known as Apert Syndrome is distinguished by early fusion of the bones of the skull and deformities in the extremities. The prevalence rate stands at 1 in every 65,000 to 160,000 births. The mutation in the FGFR2 gene affects bone and dermatological development, causing relevant dermatological complications, such as severe acne and insufficient healing. Objective: The purpose of this article is to examine the dermatological strategies and treatments applied to children suffering from this syndrome. Methods: The methodology used involved a meticulous analysis of medical literature in databases such as PubMed and Scopus, selecting relevant research in English and Spanish languages. Evaluations of diagnostic and therapeutic strategies were carried out, identifying a diversity of dermatological manifestations and associated complications. Results and discussion: The findings indicate that the diagnosis is based on clinical assessment and genetic testing. Management should adopt a multidisciplinary approach, incorporating surgical interventions in early stages to prevent brain complications. Dermatological manifestations such as severe acne demand specialized therapeutic intervention with oral retinoids. Conclusion: The importance of implementing early diagnoses and multidisciplinary approaches is emphasized. Despite the progress made in treatments, more research is required to develop standardized protocols that enhance the quality of life of patients.