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Introduction: Endometriosis is a chronic gynecological condition characterized by the presence of endometrial tissue outside the uterine cavity, causing symptoms such as pelvic pain, infertility, and menstrual changes. Although its etiology is not yet fully understood, genetic, immunological, and environmental factors have been identified as important in its pathogenesis. Methods: This is an systematic review conducted through the Scopus, PubMed®, and SciELO databases, using the descriptors ketamine, bipolar disorder, and treatment. Studies published in the last 18 years, in English, Spanish, or Portuguese, that addressed the topic were included. Results and discussions: The association between endometriosis and autoimmune diseases is inconsistent. Some studies indicate an increased risk of systemic lupus erythematosus and Sjögren's syndrome, especially in young women and in the first years after diagnosis of endometriosis. Inflammatory bowel diseases showed a clearer relationship with endometriosis, while rheumatoid arthritis and multiple sclerosis did not show significant evidence. Conclusion: The relationship between endometriosis and autoimmune diseases is complex and requires further studies to understand the underlying mechanisms and confirm the findings, especially considering factors such as age and hormonal treatments.
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Copyright (c) 2024 Paulo Vytor Cardoso Nobre, Ana Carolina Cansanção Melro, Laura Patriota Palhares, Izadora Magalhães Vasconcellos, Carine Marcele Vital de França, Rafaella Ribeiro Falcão Fernandes, Mariana Gomes da Silva, Maria Eduarda de Oliveira Bezerra Costa, Caroline de Albuquerque Alencar