Abstract
Introduction: Chronic kidney disease (CKD) and obesity are diseases with a high mortality rate and which are of great relevance to public health worldwide due to their great influence on the living conditions of those affected, changes in lifestyle habits and even limitations in terms of work or leisure programs. According to studies, obese people can increase their risk of developing CKD by 83% compared to healthy people due to factors associated with obesity or underlying diseases already present in the patient, as well as being a disease that affects 1 in 10 people worldwide. Objective: To verify the main challenges faced by physicians in the management of chronic kidney disease in obese patients Methodology: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standard protocol checklist will be used. Articles were retrieved from electronic databases: Biblioteca Virtual em Saúde, Scientific Electronic Library Online (Scielo Brasil) and Pubmed, which evaluated obese adult patients with CKD. A qualitative assessment of the studies was conducted. Expected results: We expect to encounter technological, structural and clinical difficulties in the management of chronic kidney disease in obese patients. Conclusion: The management of Chronic Kidney Disease (CKD) in obese patients presents numerous clinical and structural challenges, mainly due to the inherent complexity of associated conditions, such as hypertension, diabetes and metabolic disorders. With this, the management of CKD in obese patients demonstrated the notorious public health problem in Brazil that this issue causes, and explains the importance of continuous research in this area, in order to improve our knowledge, prevention and treatment strategies for these patients.
References
AMERICAN PSYCHIATRIC ASSOCIATION. *Manual Diagnóstico e Estatístico de Transtornos Mentais, 5ª edição*. In: FREITAS, G. B. L. (Ed.). *Saúde Mental: Desafios da Prevenção, Diagnóstico, Tratamento e Cuidado na Sociedade Moderna - Edição X* [Internet]. 5ª ed. Porto Alegre: Artmed, 2023. p. 160–163. Disponível em: <https://editorapasteur.com.br/publicacoes/capitulo/?codigo=2289>. Acesso em: 06 jul. 2024.
GÓRALCZYK-BIŃKOWSKA, A.; SZMAJDA-KRYGIER, D.; KOZŁOWSKA, E. The Microbiota–Gut–Brain Axis in Psychiatric Disorders. *International Journal of Molecular Sciences*, v. 23, n. 19, p. 1–23, 2022.
PAGE, M. J. et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. *BMJ* [Internet], 2021. Disponível em: <https://www.bmj.com/lookup/doi/10.1136/bmj.n71>. Acesso em: 06 jul. 2024.
NUMBER of suicide deaths have risen globally to over 800,000 in 2016 | BMJ [Internet]. [cited 2023 Jun 12]. Disponível em: <https://www.bmj.com/company/newsroom/number-of-suicide-deaths-have-risen-globally-to-over-800000-in-2016>. Acesso em: 06 jul. 2024.
CHAHWAN, B. et al. Gut feelings: A randomized, triple-blind, placebo-controlled trial of probiotics for depressive symptoms. *Journal of Affective Disorders* [Internet], v. 253, p. 317–326, 2019. Disponível em: <https://doi.org/10.1016/j.jad.2019.04.097>. Acesso em: 06 jul. 2024.
HOU, K. et al. Microbiota in health and diseases. *Signal Transduction and Targeted Therapy*, v. 7, n. 1, 2022.
CASPANI, G. et al. Gut microbial metabolites in depression: Understanding the biochemical mechanisms. *Microbial Cell*, v. 6, n. 10, p. 454–481, 2019.
SHEEHAN, D. V. et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. *Journal of Clinical Psychiatry*, v. 59, supl. 20, p. 22–33, 1998.
WIDEMAN, T. H. et al. Beck Depression Inventory (BDI). In: Encyclopedia of Behavioral Medicine [Internet]. New York, NY: Springer New York, 2013. p. 178–179. Disponível em: <http://link.springer.com/10.1007/978-1-4419-1005-9_44113>. Acesso em: 06 jul. 2024.
PAGE, M. J. et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. *Journal of Clinical Epidemiology*, v. 134, p. 178–189, 2021. doi: 10.1016/j.jclinepi.2020.11.012.
WELLS, G. A. et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses. Ottawa: Ottawa Hospital Research Institute, 2011. Disponível em: <http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp>. Acesso em: 06 jul. 2024.
GUYATT, G. H. et al. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. *BMJ*, v. 336, p. 924–926, 2008. doi: 10.1136/bmj.39489.470347.AD.
PROSPERO: *Prospective Register of Systematic Reviews* [Internet]. York (RU): Centre for Reviews and Dissemination (CRD); c2022. Disponível em: <https://www.crd.york.ac.uk/prospero/>. Acesso em: 06 jul. 2024.

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Copyright (c) 2024 Thigo Souza Rafael Alves, João Gabriel Santos Silva Tupinambá , Marcus Vinícius Teixeira Bastos, Luis Kleber Reis Andrade , Carlos Eduardo Andrade da Cruz, Maria Olinda Nogueira Avila