Efficiency of Lecanemab in the management of Alzheimer's Disease: an integrative review

Authors

  • Victória Souza Marques Graduado em Medicina pela Faculdades Unidas do Norte de Minas
  • Ricardo Vieira Bittencourt Graduado em Medicina pela Faculdades Unidas do Norte de Minas
  • Cecília Soares de Oliveira Graduado em Medicina pela Faculdades Unidas do Norte de Minas
  • Julyana Eulália Pereira Pessoa Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Maria Ester Gonçalves Ferreira Cavalcanti Manso Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Bruno Oliveira Góes Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Camilla Catarina Braz de Albuquerque pontes Lopes Graduando em Medicina pela Faculdade de Medicina de Olinda
  • Leticia Melo Guimarães Pinto Graduando em Medicina pelo Centro Universitário de Maceió
  • Wilson Moraes Amaral Júnior Graduando em Medicina pelo Centro Universitário de Maceió
  • Rostand Ramos de Lima Cavalcanti Filho Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Hulfshoff Damasceno Gama Graduando em Medicina pelo Centro Universitário de Maceió
  • Paulo Brian Fagundes Graduando em Medicina pela Faculdade Pitágoras
  • João Vítor Tomaz Ribeiro Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Franciele Rabelo Braga Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Maria Eduarda Lapa Nogueira Lima Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Walter Borges de Almeida Graduando em Medicina pela Faculdade Pitágoras
  • Natália Caminha Freire de Albuquerque Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Bruna Lima Farias Batista Graduado em Medicina pela Faculdade de Medicina de Olinda

DOI:

https://doi.org/10.36557/2674-8169.2024v6n9p2022-2031

Keywords:

Lecanemab, Alzheimer's disease, anti-beta-amyloid, treatment

Abstract

Introduction: Lecanemab is a monoclonal antibody used in the treatment of Alzheimer's disease, specifically on soluble beta-amyloid oligomers, with the aim of facilitating removal from the immune system, reducing the load of beta-amyloid in the brain. Objective: to evaluate the impacts of lecanemab in the treatment of Alzheimer's Disease. Methods: It consists of an integrative review carried out through the Scopus, PubMed® and SciELO databases, using the descriptors Lecanemab, Alzheimer's disease and anti-beta-amyloid. Studies published in the last 9 years, in English, Spanish or Portuguese, that addressed the topic were included. Results: Lecanemab showed consistent efficacy in reducing cerebral amyloid plaques, associated with Alzheimer's disease, in addition to cognitive and functional benefits. However, there were some adverse effects such as infusion-related and occurrence of amyloid imaging-related abnormalities. Considerations: Lecanemab demonstrates greater efficacy than placebo in reducing Aβ burden in early stages of AD, with a significant impact on reducing amyloid plaques and delaying cognitive decline. The drug was well tolerated, resulting in an acceptable safety profile. However, despite promising results, long-term studies are needed to fully evaluate its safety and efficacy profile.

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Published

2024-09-08

How to Cite

Marques , V. S., Ricardo Vieira Bittencourt, Cecília Soares de Oliveira, Julyana Eulália Pereira Pessoa, Maria Ester Gonçalves Ferreira Cavalcanti Manso, Bruno Oliveira Góes, Camilla Catarina Braz de Albuquerque pontes Lopes, Leticia Melo Guimarães Pinto, Wilson Moraes Amaral Júnior, Rostand Ramos de Lima Cavalcanti Filho, Hulfshoff Damasceno Gama, Paulo Brian Fagundes, João Vítor Tomaz Ribeiro, Franciele Rabelo Braga, Maria Eduarda Lapa Nogueira Lima, Walter Borges de Almeida, Natália Caminha Freire de Albuquerque, & Bruna Lima Farias Batista. (2024). Efficiency of Lecanemab in the management of Alzheimer’s Disease: an integrative review. Brazilian Journal of Implantology and Health Sciences, 6(9), 2022–2031. https://doi.org/10.36557/2674-8169.2024v6n9p2022-2031

Issue

Vol. 6 No. 9 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Original article

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Copyright (c) 2024 Victória Souza Marques , Ricardo Vieira Bittencourt, Cecília Soares de Oliveira, Julyana Eulália Pereira Pessoa, Maria Ester Gonçalves Ferreira Cavalcanti Manso, Bruno Oliveira Góes, Camilla Catarina Braz de Albuquerque pontes Lopes, Leticia Melo Guimarães Pinto, Wilson Moraes Amaral Júnior, Rostand Ramos de Lima Cavalcanti Filho, Hulfshoff Damasceno Gama, Paulo Brian Fagundes, João Vítor Tomaz Ribeiro, Franciele Rabelo Braga, Maria Eduarda Lapa Nogueira Lima, Walter Borges de Almeida, Natália Caminha Freire de Albuquerque, Bruna Lima Farias Batista

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