Efficacy of tranexamic acid in the management of melasma: An integrative review

Authors

  • Carolline Vaz Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Júlia Leandra Fernandes Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Isadora Alves de Andrade Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Pierre Rodrigues Bernardino Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Victor Hugo Mundim Melo Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Ana Carolina Benaventana de Padua Carneiro Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Alex Italo da Silveira Sales Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Gabrielly Alves Trigo
  • Rodrigo Cordon Isaac Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Jheniffer da Silva Oliveira Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Thomas de Matos Soares Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Giovana Menezes Graduando em Medicina pela Universidade Federal do Triângulo Mineiro
  • Allycia Jamylle Nogueira de Mello Graduando em Medicina pelo Centro Universitário de Maceió
  • Maria Luiza Normande Guido Santos Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Mariana Alencar Máximo Lacerda Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Marina Lins Tavares Pedroza Monteiro Graduado em Medicina pela Faculdade de Medicina de Olinda
  • Maria Karoline Gomes da Silva Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Brunna Karolyne Aguiar Ferreira Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Lucélia Barros Tenório Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Bruna Michelly de Barros Canuto Pinheiro Graduando em Medicina pelo Centro de Estudos Superiores de Maceió
  • Bruna Tavares Oliveira Graduando em Medicina pelo Centro de Estudos Superiores de Maceió

DOI:

https://doi.org/10.36557/2674-8169.2024v6n9p1063-1073

Keywords:

tranexamic acid, Melasma, treatment, safety

Abstract

Introduction: Tranexamic acid, an anti-fibrinolytic agent, has been used in the treatment of melasma, a hyperpigmentary condition that causes dark patches on the skin. Its effectiveness in melasma is related to the inhibition of plasminogen activation, a protein involved in the formation of melanin. Objective: to analyze the effects of tranexamic acid in the treatment of melasma. Methods: It consists of an integrative review carried out through the Scopus, PubMed® and SciELO databases, using the descriptors tranexamic acid, safety and melasma. Studies published in the last 12 years, in English, Spanish or Portuguese, that addressed the topic were included. Results and discussions: TXA combined with different therapies, especially lasers, is effective and safe in the treatment of melasma, showing better results than monotherapy. Intradermal administration of TXA often results in better clinical outcomes compared to the topical form. Considerations: It is concluded that TXA offers an effective and safe option for the treatment of melasma, highlighting its potential as a valuable tool in the therapeutic arsenal against melasma.

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References

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Published

2024-09-03

How to Cite

Vaz, C., Júlia Leandra Fernandes, Isadora Alves de Andrade, Pierre Rodrigues Bernardino, Victor Hugo Mundim Melo, Ana Carolina Benaventana de Padua Carneiro, Alex Italo da Silveira Sales, Gabrielly Alves Trigo, Rodrigo Cordon Isaac, Jheniffer da Silva Oliveira, Thomas de Matos Soares, Giovana Menezes, Allycia Jamylle Nogueira de Mello, Maria Luiza Normande Guido Santos, Mariana Alencar Máximo Lacerda, Marina Lins Tavares Pedroza Monteiro, Maria Karoline Gomes da Silva, Brunna Karolyne Aguiar Ferreira, Lucélia Barros Tenório, Bruna Michelly de Barros Canuto Pinheiro, & Bruna Tavares Oliveira. (2024). Efficacy of tranexamic acid in the management of melasma: An integrative review. Brazilian Journal of Implantology and Health Sciences, 6(9), 1063–1073. https://doi.org/10.36557/2674-8169.2024v6n9p1063-1073

Issue

Vol. 6 No. 9 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Original article

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Copyright (c) 2024 Carolline Vaz, Júlia Leandra Fernandes, Isadora Alves de Andrade, Pierre Rodrigues Bernardino, Victor Hugo Mundim Melo, Ana Carolina Benaventana de Padua Carneiro, Alex Italo da Silveira Sales, Gabrielly Alves Trigo, Rodrigo Cordon Isaac, Jheniffer da Silva Oliveira, Thomas de Matos Soares, Giovana Menezes, Allycia Jamylle Nogueira de Mello, Maria Luiza Normande Guido Santos, Mariana Alencar Máximo Lacerda, Marina Lins Tavares Pedroza Monteiro, Maria Karoline Gomes da Silva, Brunna Karolyne Aguiar Ferreira, Lucélia Barros Tenório, Bruna Michelly de Barros Canuto Pinheiro, Bruna Tavares Oliveira

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