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Abstract
Introduction: Tranexamic acid, an anti-fibrinolytic agent, has been used in the treatment of melasma, a hyperpigmentary condition that causes dark patches on the skin. Its effectiveness in melasma is related to the inhibition of plasminogen activation, a protein involved in the formation of melanin. Objective: to analyze the effects of tranexamic acid in the treatment of melasma. Methods: It consists of an integrative review carried out through the Scopus, PubMed® and SciELO databases, using the descriptors tranexamic acid, safety and melasma. Studies published in the last 12 years, in English, Spanish or Portuguese, that addressed the topic were included. Results and discussions: TXA combined with different therapies, especially lasers, is effective and safe in the treatment of melasma, showing better results than monotherapy. Intradermal administration of TXA often results in better clinical outcomes compared to the topical form. Considerations: It is concluded that TXA offers an effective and safe option for the treatment of melasma, highlighting its potential as a valuable tool in the therapeutic arsenal against melasma.
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Copyright (c) 2024 Carolline Vaz, Júlia Leandra Fernandes, Isadora Alves de Andrade, Pierre Rodrigues Bernardino, Victor Hugo Mundim Melo, Ana Carolina Benaventana de Padua Carneiro, Alex Italo da Silveira Sales, Gabrielly Alves Trigo, Rodrigo Cordon Isaac, Jheniffer da Silva Oliveira, Thomas de Matos Soares, Giovana Menezes, Allycia Jamylle Nogueira de Mello, Maria Luiza Normande Guido Santos, Mariana Alencar Máximo Lacerda, Marina Lins Tavares Pedroza Monteiro, Maria Karoline Gomes da Silva, Brunna Karolyne Aguiar Ferreira, Lucélia Barros Tenório, Bruna Michelly de Barros Canuto Pinheiro, Bruna Tavares Oliveira