A EFICÁCIA DO USO DO CANABIDIOL NO TRATAMENTO DE MULHERES COM ENDOMETRIOSE: UMA REVISÃO SISTEMÁTICA.

Abstract

INTRODUCTION: Endometriosis is characterized by the presence of ectopic endometrial tissue, meaning that endometrial cells, which have traveled in the opposite direction of natural menstruation, attach to structures within the pelvic and/or abdominal cavity. Due to a pathophysiology that is still partly unknown, these cells begin to proliferate, causing lesions that evolve into endometriosis, resulting in pelvic pain, infertility, and other symptoms. Diagnosis is typically delayed, and the available treatments are limited to pain relievers, lifestyle changes, and sometimes surgery. In recent years, cannabidiol, a compound from Cannabis sativa, has emerged as an effective alternative for integrating pain management therapy. OBJECTIVE: The objective of this study is to evaluate the effectiveness of cannabidiol in patients diagnosed with endometriosis for pain treatment. METHODOLOGY: This is a scope review of articles published in English, Portuguese, or Spanish between January 2019 and July 2024, and included in one of six databases: PubMed, Science Direct, Scielo, BVS, Wiley Online Library, and BASE. The keywords used were "Cannabidiol," "Endometriosis," and "Pelvic Pain," with the Boolean operator "AND". RESULTS: A total of 91 articles were found, of which four were duplicates and 79 were rejected for not meeting the inclusion criteria or for matching an exclusion criterion. Only eight articles were selected. CONCLUSION: Cannabidiol has been shown to be effective for therapeutic use in managing pelvic pain in patients with endometriosis.