Abstract
Introduction: Anal fissures are common pathologies that can lead to short- and long-term complications in patients. They have variable etiology, and are mostly due to intestinal constipation. The therapeutic principles consist of reducing the traumatic mechanism, relieving symptoms, and reversing sphincter hypertonia. Drug treatment is based on the use of topical diltiazem. The objective of this study was to study the efficacy of Aloe Vera, comparing it with that of Diltiazem, since it has been proven that fresh Aloe Vera can improve wound healing. Method: literature review with search in the Scielo, PubMed, and Google Scholar databases. Inclusion and exclusion criteria were applied, and 70 articles were selected to compose the study. Results and Discussion: Anal fissure consists of a solution of continuity of the lining of the anal canal located distally to the mucocutaneous junction. Typical symptoms include proctalgia and rectal bleeding associated with defecation, which can often be accompanied by constipation. Conservative treatment involves the use of botulinum toxin, nitroglycerin, lidocaine, or calcium channel blockers such as diltiazem or nifedipine. Considering that Brazil has a wide variety of native plant species, phytotherapy has been increasingly used in pathologies. Studies have shown the benefits of Aloe vera for therapeutic purposes, acting as an antimicrobial, emollient, anesthetic, and healing agent, acting on the regeneration of cellular tissue, and controlling the inflammatory process. Conclusion: The use of Aloe vera in the treatment of fissures has shown significant efficacy, in addition to being low cost, more accessible, and with good therapeutic adherence by patients.
References
ALA S, S.M, HADIANAMREI R, GHORBANIAN A. Topical diltiazem vs. topical glyceriltrinitrate in the treatment of chronic anal fissure: a prospective, randomized,doubleblindtrial. ActaGastroenterol Belg. 2012 Dec; 75(4):438-42.
ALTOMARE, D.F et al. The management of patients with primary chronic anal fissure: a position paper.Techniques InColoproctology, [s.l.], v. 15, n. 2, p.135-141, 3 maio 2011. Springer Science and Business Media LLC. Disponível em: http://dx.doi.org/10.1007/s10151-011-0683-7. Acesso em: 04 abr 2020
AMARO, P. DUARTE, A. Fissura anal, Parte I – Fundamentos Teóricos. Revista portuguesa de coloproctologia,Portugal, v. 6, n. 1, p.18-26. 2009.a
AMARO, P; DUARTE, A. FISSURA ANAL PARTE II - ABORDAGEM PRÁTICA. Revista Portuguesa de Coloproctologia, Portugal, v. 8, n. 2, p.30-32, jan. 2009.b
ARROJA, B. et al. TOXINA BOTULÍNICA NO TRATAMENTO DA FISSURA ANAL CRÓNICA: ANÁLISE RETROSPECTIVA DE 93 CASOS. Revista Porguesa de Coloproctologia, Leiria, Portugal, v. 2, n. 7, p.54-59, jan. 2010.
ATHERTON, P. Aloe vera revisited.The British Journal of Phytotherapy, v.4, n.4, p.176-83, 1997.
BHARDWAJ, R; PARKER, Mc. Modern Perspectives in the Treatment of Chronic Anal Fissures. The Annals Of The Royal College Of Surgeons Of England, [s.l.], v. 89, n. 5, p.472-478, jul. 2007. Royal College of Surgeons of England. Disponível em: http://dx.doi.org/10.1308/003588407x202137. Acesso em: 04 abr. 2020
BIELECKI K, KOLODZIEJCZAK M. A prospective randomized trial of diltiazem and glyceryltrinitrate ointment in the treatment of chronic anal fissure. Colorectal Dis 2003; 5(3):256-7.
BOLTON TB. Mechanisms of action of transmitters and other substances on smooth muscle. PhysiolRev 1979; 59(3):606-718.
BRANCO NETO, M.L.C et al. Avaliação do extrato hidroalcoólico de Aroeira (SchinusterebinthifoliusRaddi) no processo de cicatrização de feridas em pele de ratos. Acta Cirurgica Brasileira, [s.l.], v. 21, n. 2, p.17-22, 2006. FapUNIFESP (SciELO). Disponível em: http://dx.doi.org/10.1590/s0102-86502006000800004. Acesso em: 05 abr 2020
CAMPOS, F.G.C.M.; ARAðJO, S.E.A; HABR, A. ETIOLOGIA E TRATAMENTO CIRÚRGICO DAS FISSURAS ANAIS.: REVISÃO SOBRE ASPECTOS HISTÓRICOS, TÉCNICOS E RESULTADOS.. Revista Brasileira de Coloproctologia, São Paulo, v. 21, n. 4, p.239-245, fev. 2001. Disponível em: https://www.sbcp.org.br/revista/nbr214/P239_245.htm. Acesso em: 04 abr. 2020.
CARAPETI EA et al. Topical diltiazem and bethanechol decreased anal sphincter pressure without side effects.Gut 1999; 45(5):719-22.
CARVALHO, P.T.C Análise da cicatrização de lesões cutâneas através da espectrofotometria: estudo experimental em ratos diabéticos. 2001. Dissertação (Mestrado em Bioengenharia) - Bioengenharia, Universidade de São Paulo, Ribeirão Preto, 2002. Disponível em: http://dx.doi.org/10.11606/D.82.2002.tde-07012003-100025. Acesso em: 31 mar 2020
CHEN, R. et al. 2014. Potential antineoplastic effects of aloe-emodin: A comprehensive review. The American Journal of Chinese Medicine 42(02):275–88.
CHITHRA P, SAJITHLAL GB, CHANDRAKASAN G. Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats. Molecular and Cellular Biochemistry, 1998; 181(1‐2):71‐6.
CHOI, C.W. et al. The wound-healing effect of a glycoprotein fraction isolated from aloe vera.British Journal of Dermatology, v.145, n.4, p.535-45, 2001.
COLLINS, E.E.; LUND, J.N..A review of chronic anal fissure management. Techniques InColoproctology, [s.l.], v. 11, n. 3, p.209-223, 3 ago. 2007. Springer Science and Business Media LLC. Disponível em: http://dx.doi.org/10.1007/s10151-007-0355-9. Acesso em: 04 abr 2020
COSTA, V.; BELEZA, L.; SILVA, J.Topical diltiazem in the relief of chronic anal fissures – Which the evidence?Revista Portuguesa de Coloproctologia, Portugal, v. 8, n. 15, p.5-12, jan. 2017.
CROSS, K. L. R. et al. The Management of Anal Fissure: ACPGBI Position Statement. Colorectal Disease, [s.l.], v. 10, p.1-7, nov. 2008. Wiley. Disponível em: http://dx.doi.org/10.1111/j.1463-1318.2008.01681.x. Acesso em 02 de abril de 2020
DAVIS RH et al.Woundhealing, oral and topical activityof Aloe vera. Journal Of The American Medical Podiatric Assoc. Nov. 1989 , 79(11): 559-562.
DAVIS, R.H. et al. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera.Journal of the American Podiatric Medical Association, v.84, n.2, p.77-81, 1994.
ESHGHI, F. et al. Effects of Aloe vera cream on posthemorrhoidectomy pain and wound healing: results of a randomized, blind, placebo-control study.The Journal of Alternative and Complementary Medicine, v.16, n.6, p.647-50, 2010.
FULTON JE. The stimulation of postdermabrasion wound healing with stabilized aloe vera gel‐polyethylene oxide dressing. The Journal of Dermatologic Surgery and Oncology, 1990;16(5):460‐7.
HAMMAN JH. CompositionandApplicationsofAloe vera Leaf Gel. Molecules: open Access journal Aug. 2008 , 13(8): 1599- 1616.
HANUMANTHAPPA MB et al.Topical Diltiazem is Superior to Topical Lignocaine in the Treatment of Chronic Anal Fissure: Results of A Prospective Comparative Study. Journal of Clinical & Diagnostic Research; 2012Aug, 6 (6):101
HEGGERS J.P.et al. Beneficial effect of aloe on wound healing in an excisional wound model. Journal of Alternative and Complementary Medicine,1996;2(2):271‐7
HOSSAIN M.S. et al. A review on ethnopharmacological potential of Aloe vera L. J. IntercultEthnopharmacol. 2013;2(2):113.
HUTTER J.A et al. Antiinflammatory C‐glucosylchromone from Aloe barbadensis. Journal of Natural Products, 1996;59(5):541‐3.
JETTANACHEAWCHANKIT, S. et al. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type 1 collagen; and wound healing. Journal of Pharmacological Sciences, v.109, p.525-31, 2009.
JONAS, M; SCHOLEFIELD, J.H. ANAL FISSURE. Gastroenterology Clinics Of North America, [s.l.], v. 30, n. 1, p.167-181, mar. 2001. Elsevier BV. Disponível em: http://dx.doi.org/10.1016/s0889-8553(05)70172-2. Acesso em: 04 abr 2020
JONAS M. et al. A randomized trial of oral vs. topical diltiazem for chronic anal fissures. DisColonRectum 2001;44: 1074-8.
JONAS M, SPEAKE W, SCHOLEFIELD JH. Diltiazem heals glyceryl trinitrateresistant chronic anal fissures: a prospective study. Dis Colon Rectum2002; 45(8):1091-5
KLEINl AD, P.N.S. Aloe vera. Journal of the American Academy of Dermatology, 1988;18(4 pt 1):714‐20.
KLOSTERHALFEN, B et al. Topography of the inferior rectal artery. Diseases Of The Colon & Rectum, [s.l.], v. 32, n. 1, p.43-52, jan. 1989. Ovid Technologies (Wolters Kluwer Health). Disponível em: http://dx.doi.org/10.1007/bf02554725. Acesso em: 04 abr de 2020
KLOSTERHALFEN B ET AL. Topography of the inferior rectal artery: a possible cause of chronic, primary anal fissure. DisColonRectum 1989; 32(1):43-52.
KNIGHT JS et al. Topical diltiazem ointment in the treatment of chronic anal fissure.Br J Surg. 2001;88:553-6.
KOCHER HM et al. Randomized clinicaltrial assessing the side-effects of glyceryl trinitrate and diltiazemhydrochloride in the treatment of chronic anal fissure. Br J Surg 2002;89(4):413-7.
LEAL, G.A. et al. A incorporação dos fitoterápicos no tratamento de feridas: uma revisão integrativa.Semana de Pesquisa da Universidade Tiradentes - Sempesq, Aracaju, v. 12, n. 1, p.1-3, out. 2016. Disponível em: https://eventos.set.edu.br/index.php/sempesq/article/view/4511/2742. Acesso em: 04 abr. 2020.
LODER, P. B.et al. ‘Reversible chemical sphincterotomy’ by local application of glyceryltrinitrate. British Journal Of Surgery, [s.l.], v. 81, n. 9, p.1386-1389, set. 1994. Wiley. Disponível em: http://dx.doi.org/10.1002/bjs.1800810949. Acesso em: 04 abr 2020
LUND JN et al. Topographic al distribution of blood supplyto the anal canal. Br J Surg 1999; 86(4):496-8.
LUND, J.N. Nitric oxide deficiency in the internal anal sphincter of patients with chronic anal fissure. International Journal Of Colorectal Disease, [s.l.], v. 21, n. 7, p.673-675, 29 jul. 2005. Springer Science and Business Media LLC. Disponível em: http://dx.doi.org/10.1007/s00384-005-0757-y. Acesso em: 04 abr 2020
MADOFF, R.D.; FLESHMAN, J.W. AGA technical review on the diagnosis and care of patients with anal fissure.Gastroenterology, [s.l.], v. 124, n. 1, p.235-245, jan. 2003. Elsevier BV. Disponível em: http://dx.doi.org/10.1053/gast.2003.50005. Acesso em: 04 abr 2020
MADOFF, R.D.; FLESHMAN, J.W. AGA technical review on the diagnosis and care of patients with anal fissure.Gastroenterology, [s.l.], v. 124, n. 1, p.235-245, jan. 2003. Elsevier BV. Disponível em: http://dx.doi.org/10.1053/gast.2003.50005. Acesso em: 04 abr 2020
MAHARJAN R. et al. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. J. TradComplemen Med. 2015;5(2015):21–26.
MALAFAIA, O. et al. Os fitoterápicos e seu potencial na cicatrização em cirurgia. Ata Cirúrgica Brasileira – Vol 21 (Suplemento 3) 2006.
MC CAULEY R.L. et al. Methods to minimize tissue loss. Postgraduate Medicine, 1990; 88(8):67‐8; 73‐7.
MOREIRA H. et al. Tratamento Clínico Conservador e Cirúrgico da Fissura Anal. Revista brasileira de Coloproctologia, 2003; vol. 23, num. 2, pg. 89-99.
NELSON, R.L et al. Operative procedures for fissure in ano. Cochrane Database Of Systematic Reviews, [s.l.], p.5-8, 9 nov. 2011. Wiley. Disponível em: http://dx.doi.org/10.1002/14651858.cd002199.pub4. Acesso em: 04 abr 2020
NELSON, R.L et al. Non surgical therapy for anal fissure. Cochrane Database Of Systematic Reviews, [s.l.], p.67-70, 15 fev. 2012. Wiley. Disponível em: http://dx.doi.org/10.1002/14651858.cd003431.pub3.Acesso em: 04 abr 2020
NOGUEIRA R.M.B, KITAMURA E.A, AGUIAR O.M. Estudo clínico da reparação tecidual de feridas cutâneas de cães tratados com papaína e colagenase. Nos. Clín. 2005;8(43):25-8.
PRUDENTE, A.L, et al. Avaliação do tratamento de fissura anal crônica com isossorbida tópica a 1%.Revista Brasileira de Coloproctologia, [s.l.], v. 30, n. 4, p.409-413, dez. 2010. Disponível em: http://dx.doi.org/10.1590/s0101-98802010000400004.Acesso em: 04 abr. 2020
RAMOS, A.P.; PIMENTEL, L.C. Ação da babosa no reparo tecidual e cicatrização.BrazilianJournalofHealt; vol.2, n.1, p.40-48, 2011. Disponível em http://inseer.ibict.br/bjh/index.php/bjh/article/viewFile/73/84 . Acesso em: 07 abril de 2020.
SAHU, P.K et al. Therapeutic and medicinal uses of Aloe vera: A review. Pharmacology & Pharmacy 4(08):599–610.2013
SAJID MS et al. Systematic review of the use of topical diltiazem compared with glyceryltrinitrate for the nonoperative management of chronic anal fissure. Colorectal Dis. 2013 Jan;15(1):19-26.
SCHMIDT, J.M.; GREENSPOON, J.S. Aloe vera dermal wound gel is associated with a delay in wound healing.Obstetrics & Gynecology, v.78, n.1, p.115-17, 1991.
SCHOUTEN, W. R.; BRIEL, J.W.; AUWERDA, J.J. Relationship between anal pressure and anodermal blood flow. Diseases Of The Colon & Rectum, [s.l.], v. 37, n. 7, p.664-669, jul. 1994. Ovid Technologies (Wolters Kluwer Health). Disponível em: http://dx.doi.org/10.1007/bf02054409. Acesso em: 04 abr 2020
SCHOUTEN WR et al. Ischaemic nature of anal fissure. Br J Surg 1996; 83(1):63-5.
SHELTON M. Aloe vera, its chemical and therapeutic properties. International Journal of Dermatology, 1991;30(10):679‐83.
SILVA, L.L. et al. Importância do uso de plantas medicinais nos processos de xerose, fissuras e cicatrização na diabetes mellitus. Rev. Bras. Pl. Med., Campinas, v.17, n.4, supl. I, p.827-835, 2015
SILVA, M. I. et al. A utilização da Pfaffiaglomeratano processo de cicatrização de feridas da pele. ABCD ArqBrasCirDig. 23(4):228-233, 2010.
SOUSA, M.M. Tratamento clínico da fissura anal crônica. Estudo comparativo entre diltiazem 2% e betanecol 0,1%. 2008. 112 f. Dissertação (Mestrado) - Curso de Medicina, Universidade de São Paulo - Usp, São Paulo, 2008. Disponível em: https://teses.usp.br/teses/disponiveis/5/5154/tde-24112008-113247/en.php. Acesso em: 04 abr. 2020.
SOUZA, M. Tratamento clínico da fissura anal crônica. Estudocomparativo entre diltiazem 2%e betanecol 0,1%. Dissertação apresentada à Faculdade de Medicina da Universidade de São Paulo para aobtenção do título de Mestre em Ciências, São Paulo, 2008.
SURJUSHE A, VASANI R, SAPLE DG. Aloe vera: a short review. Indian Journal of Dermatology, 2008;53(4):163‐6.
UTZIG, M. J.; KROESEN, A. J.; BUHR, H. J.. Concepts in pathogenesis and treatment of chronic anal fissure-a review of the literature. The American Journal Of Gastroenterology, [s.l.], v. 98, n. 5, p.968-974, maio 2003. Ovid Technologies (Wolters Kluwer Health). Disponível em: http://dx.doi.org/10.1111/j.1572-0241.2003.07423.x. Acesso em: 04 abr 2020
VAN KEMSEKE, C.; BELAICHE, J. Medical Treatment of Chronic Anal Fissure. Where do we stand on Reversible Chemical Sphincterotomy ?Acta Gastro-enterologicaBelgica, Belgica, v. 67, n. 3, p.265-271, jun. 2004. Disponível em: https://orbi.uliege.be/bitstream/2268/185083/1/2004%20CVKS-Medical%20treatment%20of%20chronic%20anal%20fissure...-Acta%20GE%20B-PostPE.pdf. Acesso em: 04 abr. 2020.
WEST DP, ZHU YF. Evaluation of aloe vera gel gloves in the treatment of dry skin associated with occupational exposure. American Journal of Infection Control, 2003;31(1):40‐2.
WINTERS WD, BENAVIDES R, CLOUSE WJ. Effects of aloe extracts on human normal and tumor cells in vitro. Economic Botany, 1981;35(1):89‐95.
WOLLINA, Uwe. Pharmacological sphincterotomy for chronic anal fissures by botulinum toxin A. Journal Of Cutaneous And Aesthetic Surgery, [s.l.], v. 1, n. 2, p.58-63, 2008. Medknow. Disponível em: http://dx.doi.org/10.4103/0974-2077.44160. Acesso em: 04 abr de 2020
ZANDI, K.et al. Antiviral activity of Aloe vera against herpes simplex virus type 2: an in vitro study.AfricanJournalofBiotechnology 6(15):1770–1773.2007
ZHANG, L.; TIZARD, I.R. Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera gel. Immunopharmacology, v.35, p.119-28, 1996.

This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Gabriela Dezan Monção, Barbara dos Reis Dal Lago Rodrigues , Celso Dal Lago Rodrigues Neto , Felipe Sanches Carneiro, Jéssica Vanessa Iglesias Furlaneto , Bruna Franco Candia , Victor Santos Coll , João Pedro da Silva Miranda Jorge , Tauanne Fernanda dos Santos , Marco Antônio de Souza Borges Tavares