Advances in the Diagnosis of Venous Thromboembolism in Pregnancy: Clinical Tools and Diagnostic Techniques

Authors

  • Ane Valéria Cardoso Nobre Residente de cirurgia geral do Hospital Calixto Midlej Filho - Santa Casa de Misericórdia de Itabuna
  • Gabryella Alzira Brito Vieira Graduado em Medicina pela Faculdade de Ciências Médicas
  • Rafael Rabêlo Jeremias Guimarães Graduando em Medicina pela Universidade Tiradentes
  • Milena de Andrade Lima Graduando em Medicina pela Universidade Tiradentes
  • Walter Borges de Almeida Graduando em Medicina pela Faculdade Pitágoras
  • Larissa Milena Nogarolli Badin Graduado em Medicina pela Universidad Católica Argentina
  • Rhayran Espindola Rodrigues Graduado em Medicina pela Universidade Federal da Grande Dourados
  • Paulo Sérgio de Souza Larrea Graduado em Medicina pela Universidade Federal da Grande Dourados
  • Matheus Gabriel Bonfim Telles Graduando em Medicina pela Universidade Federal da Grande Dourados
  • Lucas Gabriel Lopes Donato Graduando em Medicina pelo Centro Universitário de Maceió
  • Izabel Cristina Barbosa Fernandes Graduando em Medicina pelo Centro Universitário de Maceió
  • Cristian Marinho Xavier Graduado em Medicina pelo Centro Universitário de Maceió
  • Marcelo Oliveira da Silva Graduado em Medicina pelo Centro Universitário de Maceió
  • Daniel Galvão Araujo Monteiro Graduado em Medicina pelo Centro Universitário de Maceió
  • Francisco José Rodrigues de Alencar Graduado em Medicina pelo Centro Universitário de Maceió
  • Thaís Laurentino Severiano Graduando em Medicina pelo Centro Universitário de Maceió
  • Sabrina Furtunato de Oliveira Graduando em Medicina pelo Centro Universitário de Maceió
  • Allycia Jamylle Nogueira de Mello Graduando em Medicina pelo Centro Universitário de Maceió
  • Monalise Lacerda Malta Brandão Graduado em Medicina pelo Centro Universitário de Maceió
  • Marina Lins Tavares Pedroza Monteiro Graduado em Medicina pelo Faculdade de Medicina de Olinda
  • Maria Luiza Normande Guido Santos Graduado em Medicina pelo Faculdade de Medicina de Olinda
  • Mariana Alencar Máximo Lacerda Graduado em Medicina pelo Faculdade de Medicina de Olinda

DOI:

https://doi.org/10.36557/2674-8169.2024v6n8p5853-5861

Keywords:

Venous thromboembolism; pregnancy; diagnosis; deep vein thrombosis

Abstract

Introduction: Pregnancy significantly alters hemostasis, increasing the risk of thrombosis due to physiological and hormonal changes. In this sense, venous thromboembolism is a critical and complex condition that represents one of the main causes of maternal morbidity and mortality. Objective: To describe the main diagnostic tools for venous thromboembolism in pregnancy. Methodology: This is a literature review that included original articles and systematic reviews in English and Portuguese, which addressed the diagnostic tools for venous thromboembolism in pregnancy, selected from the PubMed, Scopus and SciELO databases. Results: The identification of DVT is challenging, since many symptoms are nonspecific during pregnancy. Methods such as compression ultrasonography (CUS), D-dimer tests and the LEFt methodology are essential, despite their limitations. Considerations: the diagnostic approach to DVT in pregnant women should be thorough and sequential, combining different methods to increase accuracy and minimize maternal-fetal risks. Repeating exams and using additional tests in cases of inconclusive results are essential strategies to ensure a safe outcome, highlighting the importance of well-defined protocols in clinical practice for the management of DVT during pregnancy.

Downloads

Download data is not yet available.

References

BAUERSACHS, R. M. et al. Risk stratification and heparin prophylaxis to prevent venous thromboembolism in pregnant women. Thrombosis and Haemostasis, v. 98, p. 1237-1245, 2007.

LIANG, Z. et al. Clinical characteristics and prognosis of cerebral venous thrombosis in Chinese women during pregnancy and puerperium. Scientific Reports, v. 7, p. 43866, 2017.

POMP, E. R. et al. Pregnancy, the postpartum period and prothrombotic defects: risk of venous thrombosis in the MEGA study. Journal of Thrombosis and Haemostasis, v. 6, p. 632-637, 2008.

JAMES, A. H. Prevention and management of venous thromboembolism in pregnancy. American Journal of Medicine, v. 120, p. S26-S34, 2007.

HUNT, B. J. Venous thromboembolism: mechanisms, treatment, and public awareness. Arteriosclerosis, Thrombosis, and Vascular Biology, v. 28, p. 398-399, 2008.

COHEN, S. L. et al. Comparison of international societal guidelines for the diagnosis of suspected pulmonary embolism during pregnancy. The Lancet Haematology, v. 7, p. e247-e258, 2020.

HENDRIKSEN, J. et al. Diagnostic prediction models for suspected pulmonary embolism: systematic review and independent external validation in primary care. BMJ, v. 351, p. h4438, 2015.

CHAN, W. S. et al. Predicting deep venous thrombosis in pregnancy: out in "LEFt" field?. Annals of Internal Medicine, v. 151, p. 85-92, 2009.

CHAN, W. S. et al. A red blood cell agglutination D-dimer test to exclude deep venous thrombosis in pregnancy. Annals of Internal Medicine, v. 147, p. 165-170, 2007.

BATES, S. M. et al. American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy. Blood Advances, v. 2, p. 3317-3359, 2018.

TORKZAD, M. R. et al. Magnetic resonance imaging and ultrasonography in diagnosis of pelvic vein thrombosis during pregnancy. Thrombosis Research, v. 126, p. 107-112, 2010.

Downloads

Published

2024-08-31

How to Cite

Nobre, A. V. C., Vieira , G. A. B., Rafael Rabêlo Jeremias Guimarães, Milena de Andrade Lima, Walter Borges de Almeida, Larissa Milena Nogarolli Badin, Rhayran Espindola Rodrigues, Paulo Sérgio de Souza Larrea, Matheus Gabriel Bonfim Telles, Lucas Gabriel Lopes Donato, Izabel Cristina Barbosa Fernandes, Cristian Marinho Xavier, Marcelo Oliveira da Silva, Daniel Galvão Araujo Monteiro, Francisco José Rodrigues de Alencar, Severiano , T. L., Oliveira , S. F. de, Mello, A. J. N. de, Brandão , M. L. M., Monteiro , M. L. T. P., Santos , M. L. N. G., & Lacerda , M. A. M. (2024). Advances in the Diagnosis of Venous Thromboembolism in Pregnancy: Clinical Tools and Diagnostic Techniques. Brazilian Journal of Implantology and Health Sciences, 6(8), 5853–5861. https://doi.org/10.36557/2674-8169.2024v6n8p5853-5861

Issue

Vol. 6 No. 8 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Original article

License

Copyright (c) 2024 Ane Valéria Cardoso Nobre, Gabryella Alzira Brito Vieira , Rafael Rabêlo Jeremias Guimarães, Milena de Andrade Lima, Walter Borges de Almeida, Larissa Milena Nogarolli Badin, Rhayran Espindola Rodrigues, Paulo Sérgio de Souza Larrea, Matheus Gabriel Bonfim Telles, Lucas Gabriel Lopes Donato, Izabel Cristina Barbosa Fernandes, Cristian Marinho Xavier, Marcelo Oliveira da Silva, Daniel Galvão Araujo Monteiro, Francisco José Rodrigues de Alencar, Thaís Laurentino Severiano , Sabrina Furtunato de Oliveira , Allycia Jamylle Nogueira de Mello, Monalise Lacerda Malta Brandão , Marina Lins Tavares Pedroza Monteiro , Maria Luiza Normande Guido Santos , Mariana Alencar Máximo Lacerda

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors are copyright holders under a CCBY 4.0 license.