Rhabdomyolysis and Its Renal Complications: Mechanisms, Diagnosis and Treatment

Authors

  • Davi Leoni Faculdade Brasileira MULTIVIX
  • Laysa Moreira Peterle
  • Maria Eduarda Zanette Macedo
  • Ana Karolline Rocha de Castro
  • Wedja Kauany Rodrigues Santos
  • Pietra Cristina Gomes Pessini
  • Lívia Busatto Pena
  • Angélica Pimenta do Amaral
  • Alice Sales Zampirolli
  • Laísa Marchette Ciciliotti
  • Natalia Bianchini Pinto

DOI:

https://doi.org/10.36557/2674-8169.2024v6n7p2443-2451

Keywords:

Keywords: Rhabdomyolysis, Renal Insufficiency, Therapeutics.

Abstract

This article aims to scan the current medical literature on the relationship between rhabdomyolysis and its renal complications, including mechanisms, diagnosis and treatment. This is an integrative review using the Virtual Health Library (VHL), LILACS and PubMed as a database over the last 10 years. It is concluded that the main complication of rhabdomyolysis is acute kidney injury (RAI), since the muscle components released into the bloodstream are nephrotoxic and treatment based on the conjugation of deferoxamine to adamantyl derivatives represents a promising approach to overcome the challenges associated with its intrinsic toxicity.

Keywords: Rhabdomyolysis, Renal Insufficiency, Therapeutics.



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References

CABRAL, B. M. I. et al. Rhabdomyolysis. Disease-a-Month, v. 66, n. 8, p. 101015, ago. 2020.

CHATZIZISIS, Y. S. et al. The syndrome of rhabdomyolysis: complications and treatment. European journal of internal medicine, v. 19, n. 8, p. 568–74, 2008.

CHAVEZ, L. O. et al. Beyond muscle destruction: a systematic review of rhabdomyolysis for clinical practice. Critical Care, v. 20, n. 1, 15 jun. 2016.

PANIZO, N. et al. Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury. Kidney and Blood Pressure Research, v. 40, n. 5, p. 520–532, 2015.

SUBASHRI, Mohanasundaram et al. Rhabdomyolysis-associated Acute Kidney Injury. Indian Journal of Nephrology, v. 33, n. 2, p. 114-118, 2023.

TORRES, P. A. et al. Rhabdomyolysis: pathogenesis, diagnosis, and treatment. The Ochsner Journal, v. 15, n. 1, p. 58–69, 2015.

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Published

2024-07-24

How to Cite

Leoni, D., Moreira Peterle, L., Zanette Macedo , M. E., Rocha de Castro , A. K., Rodrigues Santos , W. K., Gomes Pessini , P. C., Busatto Pena, L., Pimenta do Amaral, A., Sales Zampirolli , A., Marchette Ciciliotti, L., & Bianchini Pinto, N. (2024). Rhabdomyolysis and Its Renal Complications: Mechanisms, Diagnosis and Treatment. Brazilian Journal of Implantology and Health Sciences, 6(7), 2443–2451. https://doi.org/10.36557/2674-8169.2024v6n7p2443-2451

Issue

Vol. 6 No. 7 (2024): BJIHS QUALIS B3 - FATOR DE IMPACTO SJIF 5.807

Section

Literature Review

License

Copyright (c) 2024 Davi Leoni, Laysa Moreira Peterle, Maria Eduarda Zanette Macedo , Ana Karolline Rocha de Castro , Wedja Kauany Rodrigues Santos , Pietra Cristina Gomes Pessini , Lívia Busatto Pena, Angélica Pimenta do Amaral, Alice Sales Zampirolli , Laísa Marchette Ciciliotti, Natalia Bianchini Pinto

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors are copyright holders under a CCBY 4.0 license.