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Abstract
The integrative review aimed to assess the efficacy and safety of semaglutide treatment in managing non-alcoholic fatty liver disease (NAFLD), addressing its impact on non-alcoholic steatohepatitis across different patient populations. Initially, 187 studies were retrieved, of which 145 were excluded for not meeting specific inclusion criteria. Following a more detailed evaluation, 5 studies were selected and included in the review. Results highlight the pleiotropic effects of semaglutide, demonstrating improvements in NASLD markers and significant reduction in cardiovascular risks. Studies in human patients showed glycemic control and weight reduction, while animal model studies revealed improvements in liver function and lipid composition. Research by Soto-Catalán et al. suggested that the effects of semaglutide may directly affect the liver, irrespective of food intake, providing a complementary perspective to human studies. The importance of these findings in clinical management of NAFLD is underscored, pointing to the need for further research to further elucidate the therapeutic effects of semaglutide in this condition.
References
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Copyright (c) 2024 Luciana Mami Kiam, Anna Luysa de Sousa Moura, Maria Clara Petinati B. da Rocha, Renato Júnior dos Reis Aguiar, Ana Leticia Rabelo de Araujo, Bruna de Lazary Castro, Brisa da Silva Lopes, Leticia Alves Santos, Júlia Valena Paiva da Fonseca, Victor Martins Farias, Barbara Antonia Dups Talah, Isabela Carvalho Gobbi
