Abstract
The COVID-19 pandemic, which began in 2020, has had serious global consequences since its inception, resulting in high morbidity and mortality. Faced with the limitation of long-term social distancing measures, there was a global mobilization to develop vaccines against SARS-COV-2. In this way, vaccines have been an ally in preventing and reducing health complications among the world's population. Furthermore, despite the benefits of the vaccine outweighing the possible risks, ocular manifestations secondary to the administration of the COVID-19 vaccine have been noted. The aim of this study is therefore to analyze the ocular findings following the Covid-19 vaccine, demonstrating the relationship between the vaccine and the appearance of ocular manifestations in previously healthy people and the worsening of comorbidities in the population with previous ocular pathologies. The research was carried out through an integrative literature review, based on searches in the databases Latin American and Caribbean Literature in Health Sciences (LILACS), the National Library of Medicine of the United States of America (MEDLINE), the Virtual Health Library (VHL) and the Electronic Scientific Library Online (SciELO), using the descriptors "Signs and Symptoms" "Ophthalmopathies", "Ocular Manifestations" and "Covid-19 Vaccines". We considered articles available between 2019 and 2023, in English and Portuguese, which addressed the proposed theme and met all the inclusion criteria. Duplicate articles, those not available in full and those that met the other exclusion criteria were discarded. As a result, ocular adverse events such as conjunctivitis, scleritis, cranial nerve palsy, orbital inflammatory disease, herpetic eye disease, retinal vascular occlusion and posterior segment diseases were observed. The vaccine was also found to have an effect on patients with previous ocular pathologies, aggravating them. It was concluded from the study that post- immunization ocular reactions can occur, but the incidence rate is quite low and self-limiting. Although rare, it is important for health professionals to be aware of and alert to possible ocular findings following administration of the Covid-19 vaccine.
References
ANG, Terence, et al. Orbital infammation following COVID‑19 vaccination: A case series and literature review. Oftamologia Internacional, [s. l.], 17 mai. 2023 DOI: https://doi.org/https://doi.org/10.1007/s10792-023-02747-6.
BALIDIS, M.; Mikropoulos, D.; Gatzioufas, Z.; de Politis, P.B.; Sidiropoulos, G.; Vassiliadis, V. Acute corneal graft rejection after anti-severe acute respiratory syndrome-coronavirus-2 vaccination: A report of four cases. Eur. J. Ophthalmol. 2021. doi: https://doi.org/10.1177/11206721211064033. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34825599/. Acesso em: 30 mai 2023.
BOLLETTA, Elena, et al. Uveitis and Other Ocular Complications Following COVID-19 Vaccination. J.Clin. Med, [s. l.], v. 10, n. 24, 5960, p. 2-14, 19 dev. 2021 DOI: https://doi.org/https://doi.org/10.3390/jcm10245960. Disponível em: https://www.mdpi.com/2077-0383/10/24/5960. Acesso em: 30 mai. 2023.
BRASIL. Portal G1. Mapa da vacinação contra Covid-19., São Paulo, 27 jan. 2023. Disponível em: https://especiais.g1.globo.com/bemestar/vacina/2021/mapa-brasil- vacina-covid/. Acessoem: 30 mai. 2023.
HASEEB, Abid A. et al. Ocular Complications Following Vaccination for COVID- 19: A One-Year Retrospective.Vaccines, [s. l.], v. 10, n. 2, p. 1-32, 21 fev. 2022 DOI: https://doi.org/ https://doi.org/10.3390/vaccines10020342. Disponível em: https://www.mdpi.com/2076-393X/10/2/342. Acesso em: 30 mai. 2023.
HUANG, Li-Ying, et al. Corneal Complications after COVID-19 Vaccination: A Systemic Review. PubMed: J. Clin Med, [s. l.], v. 11, n. 22, p. 1-10, nov. 2022 DOI: https://doi.org/ https://doi.org/10.3390/jcm11226828. Disponível em:https://pubmed.ncbi.nlm.nih.gov/36431307. Acesso em: 30 mai. 2023
KUMARI, Shalini, et al. Ocular adverse effects of COVID-19 vaccines: A systematic review. Journal of Family Medicine and Primary Care, v. 11, n. 9, p. 5041-5054, set. 2022 DOI: https://doi.org/10.4103/jfmpc.jfmpc_747_22. Disponível em:https://journals.lww.com/jfmpc/Fulltext/2022/09000/Ocular_adverse_effects_of
_COVID_19_vaccines A.16.aspx. Acesso em: 30 mai. 2023.
LAKATOS, Eva Maria; MARCONI, Marina de Andrade. Metodologia científica.
ed. São Paulo: Atlas, 2000.
LEE, Yu-Kuei; HUANG, Yi-Hsun. Ocular Manifestations after Receiving COVID- 19 Vaccine: A Systematic Review. MDPI:Vaccines, [s. l.], v. 9, n. 1404, p. 2-14, 27 nov. 2021 DOI: https://doi.org/ https://doi.org/10.3390/vaccines9121404. Disponível em: https://www.mdpi.com/2076-393X/9/12/1404. Acesso em: 30 mai. 2023.
LI, Jing-Xing, et al. Risk assessment of retinal vascular occlusion after COVID-19 vaccination. Vaccines, [s. l.], v. 8, n. 64, p. 1-10, 2 mai. 2023 DOI: https://doi.org/; https://doi.org/10.1038/s41541-023-00661-7. Disponível em: https://www.nature.com/articles/s41541-023-00661-7. Acesso em: 30 mai. 2023.
MCINTOSH, Kenneth. COVID-19: Epidemiology, virology, and prevention. UpToDate, [s. l.], 23 mai. 2023. Disponível em: https://sso.uptodate.com/contents/covid-19-epidemiology-virology-and prevention?search=covid%20virologia&source=search_result&selectedTitle=1~150 &usage_type=default&display_rank=1. Acesso em: 30 mai. 2023.
OMS. OMS afirma que Covid-19 é agora caracterizada como pandemia, 11 mar. 2020. Disponível em: https://www.paho.org/pt/news/11-3-2020-who-characterizes- covid-19-pandemic. Acesso em: 30 mai. 2023.
OMS. Painel do Coronavírus da OMS (COVID-19), 23 mai. 2023. Disponível em: https://covid19.who.int/. Acesso em: 30 mai. 2023.
RABINOVITCH T, Ben-Arie-Weintrob Y, Hareuveni-Blum T, et al. Uveitis following the BNT162b2 mRNA vaccination against SARS-CoV-2 infection: a possible association. Retina. 2021 in press. doi:10.1097/iae.0000000000003277. Disponível em: https://pubmed.ncbi.nlm.nih.gov/34369440/. Acesso em: 30 mai. 2023.
SILVA, Letícia S. C. da, et al.Vascular retinal findings after COVID-19 vaccination in 11 cases: a coincidence or consequence? Arquivos Brasileiros de Oftalmologia, [s. l.], v. 85, n. 2, p. 158-165, 21 jan. 2022 DOI:
https://doi.org/https://doi.org/10.5935/0004-2749.20220071. Disponível em: https://www.scielo.br/j/abo/a/VTmcDYhtfHrkCVKxVLbSMDz/#. Acesso em: 30 mai. 2023.
SERHAN, Hashem Abu, et al. Ocular Vascular Events following COVID-19 Vaccines: A Systematic Review. Vaccines, [s. l.], v. 10, n. 12, p. 1-14, 14 dez. 2022 DOI: https://doi.org/ https://doi.org/10.3390/vaccines10122143. Disponível em: https://www.mdpi.com/2076-393X/10/12/2143. Acesso em: 30 mai. 2023
WANG, Michael T.M, et al. COVID-19 Vaccination and The Eye. American Journal of Ophthalmology, [s. l.], v. 240, p. 79-98, 24 fev. 2022 DOI: https://doi.org/DOI:https://doi.org/10.1016/j.ajo.2022.02.011. Disponível em: https://www.ajo.com/article/S0002-9394(22)00070-8/fulltext. Acesso em: 30 mai. 2023.

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