Keywords
tratamento
microbiota
How to Cite
Abstract
The article examines a variety of recent advancements and therapeutic perspectives in the treatment of major depression (MDD), from traditional methods to new pharmacological and non-pharmacological approaches, including the impact of the gut-brain-microbiota axis. It discusses the role of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs), as well as new therapeutic targets such as ketamine and psychedelics. Non-pharmacological therapies such as phototherapy, repetitive transcranial magnetic stimulation (rTMS), psychological intervention, and acupuncture are explored. Psilocybin is considered a potential therapeutic option, as well as the role of probiotics in modulating the gut microbiome. However, the need for controlled clinical trials to evaluate the efficacy and safety of these approaches before widespread adoption in clinical practice is emphasized, highlighting the importance of individualized treatment for each patient.
References
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Copyright (c) 2024 Leonardo Pereira Levada, Thomás Pereira Cruz , Júlia Letícia De Souza Barbosa, Camila de Assis França, Amanda Freitas Santos, Samanttha Sanches de Oliveira , Maria Victoria Dantas Barros, Lucas Ferreira da Costa, Janaína Santos Costa Lopes, Arthur César Cota de Castro, Guilherme Tambosi Baseman, Ítalo Dias Bonfim, Mariana Alves da Cunha, Marcela Rodrigues Melo, Eduardo Moraes Guimarães, Carlos Alves Silva