Contemporary Views on Treatments for Depression: An Analysis of Recent Literature
DOI:
https://doi.org/10.36557/2674-8169.2024v6n4p1034-1044Keywords:
Depressão, tratamento, microbiotaAbstract
The article examines a variety of recent advancements and therapeutic perspectives in the treatment of major depression (MDD), from traditional methods to new pharmacological and non-pharmacological approaches, including the impact of the gut-brain-microbiota axis. It discusses the role of tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine reuptake inhibitors (SNRIs), as well as new therapeutic targets such as ketamine and psychedelics. Non-pharmacological therapies such as phototherapy, repetitive transcranial magnetic stimulation (rTMS), psychological intervention, and acupuncture are explored. Psilocybin is considered a potential therapeutic option, as well as the role of probiotics in modulating the gut microbiome. However, the need for controlled clinical trials to evaluate the efficacy and safety of these approaches before widespread adoption in clinical practice is emphasized, highlighting the importance of individualized treatment for each patient.
Downloads
References
BRASIL. Lei Nº 12.853. Brasília: 14 de agosto de 2013.
CHAND, S.; ARIF, H. Depression. Disponível em: <https://www.ncbi.nlm.nih.gov/books/NBK430847/>.
CUI, L. et al. Major depressive disorder: hypothesis, mechanism, prevention and treatment. Signal Transduction and Targeted Therapy, v. 9, n. 1, p. 1–32, 9 fev. 2024.
GAO, J. et al. Probiotics for the treatment of depression and its comorbidities: A systemic review. v. 13, 17 abr. 2023.
KOLASA, M.; AGATA FARON-GÓRECKA. Preclinical models of treatment-resistant depression: challenges and perspectives. Pharmacological Reports, v. 75, n. 6, p. 1326–1340, 26 out. 2023.
LESTER, T. R. et al. Anxiety and Depression Treatment in Primary Care Pediatrics. v. 151, n. 5, 17 abr. 2023.
NOETEL, M. et al. Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials. BMJ, v. 384, n. 8417, p. e075847, 14 fev. 2024.
PEREZ, N. et al. Psilocybin-assisted therapy for depression: A systematic review and dose-response meta-analysis of human studies. European Neuropsychopharmacology, v. 76, p. 61–76, 1 nov. 2023.
RADFORD-SMITH, D. E.; ANTHONY, D. C. Prebiotic and Probiotic Modulation of the Microbiota–Gut–Brain Axis in Depression. Nutrients, v. 15, n. 8, p. 1880, 1 jan. 2023.
SINGH, B. et al. Effectiveness of physical activity interventions for improving depression, anxiety and distress: an overview of systematic reviews. British Journal of Sports Medicine, v. 57, n. 18, 16 fev. 2023.
THAKUR, T. et al. The Role of Omega-3 Fatty Acids in the Treatment of Depression in Children and Adolescents: A Literature Review. Curēus, 2 set. 2023.
XIONG, R.-G. et al. The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components. Nutrients, v. 15, n. 14, p. 3258, 2023.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Leonardo Pereira Levada, Thomás Pereira Cruz , Júlia Letícia De Souza Barbosa, Camila de Assis França, Amanda Freitas Santos, Samanttha Sanches de Oliveira , Maria Victoria Dantas Barros, Lucas Ferreira da Costa, Janaína Santos Costa Lopes, Arthur César Cota de Castro, Guilherme Tambosi Baseman, Ítalo Dias Bonfim, Mariana Alves da Cunha, Marcela Rodrigues Melo, Eduardo Moraes Guimarães, Carlos Alves Silva
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors are copyright holders under a CCBY 4.0 license.
