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Abstract
GOALS: To evaluate the serum concentrations of 25-hydroxyvitamin D, 25(OH)D, in osteoporotic patients treated for one year with calcifediol.
METHODS: We studied 156 patients with osteoporosis (23 men and 133 women) aged 71.9 ± 9.6 years who had been treated with calcifediol for at least one year. Ninety-two of them received 0.266 mg calcifediol every 15 days and he remaining 64 received the same dose once a month. Serum levels of 25(OH)D, intact PTH (iPTH), amino-terminal procollagen type I propeptide (PINP) and carboxy-terminal collagen type I telopeptide (CTX) were determined before and one year after the start of treatment .
RESULTS: With both treatment regimens, a significant increase in 25(OH)D concentration was observed (p<0.001). The percentage of patients achieving 25(OH)D levels greater than 20 and 30 ng/ml was similar with both regimens, whereas that of patients exceeding 60 ng/ml was higher with the biweekly dose (p < 0.01 ) . The iPTH concentration significantly decreased after administration of calcifediol, although on this occasion there were no differences between the two forms of treatment. Both markers, PINP and CTX, similarly decreased in patients treated with antiresorptives (p < 0.0001), without these changes being related to the calcifediol regimen.
CONCLUSIONS: A monthly administration of 0.266 mg calcifediol is adequate to achieve effective levels of vitamin D, and is also safe enough to avoid potentially harmful levels of vitamin D, so it would be preferable to the biweekly regimen in standard clinical practice.
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Este artigo é uma cópia com adaptação para o português do original “Olmos, J. M., et al. "Calcifediol mensual frente a calcifediol quincenal en el tratamiento de pacientes osteoporóticos. Estudio en la vida real." Revista de Osteoporosis y Metabolismo Mineral 10.2 (2018): 89-95.”25
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