Keywords
How to Cite
Abstract
Chronic obstructive pulmonary disease (COPD) is considered the fourth cause of death in Brazil, a worrying scenario considering that only 10% of those diagnosed receive adequate treatment. The present review study sought to evaluate new advances in the management of COPD exacerbations, documented through clinical and randomized studies. This is an integrative review research carried out using the PubMed database, which took into account the following inclusion criteria: clinical trials and controlled and randomized tests; articles published in the last year; that had full text available and that addressed the management of COPD exacerbations. Xiyanping has been found to have the ability to inhibit the inflammatory response throughout the body and provide a significant synergistic effect when combined with antibiotics, resulting in improved lung function in elderly people with acute exacerbation of COPD. Furthermore, a reduction in airway reactivity and an increase in secretion clearance were observed. Patients with COPD who have high baseline FENO levels and have not been previously treated may benefit from the use of salmeterol/fluticasone instead of tiotropium, indicating that high FENO levels may predict a favorable response to ICS/LABA treatment. Finally, acupuncture has been shown to be an effective and safe adjunctive approach in the treatment of acute exacerbations of COPD, with patients reporting significant improvements.
References
COELHO, A. E. C. et al. Abordagem geral da Doença Pulmonar Obstrutiva Crônica (DPOC): uma revisão narrativa. Revista Eletrônica Acervo Médico, v. 1, n. 1, p. e8657, 2021.
COTTON, S. et al. Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS). Trials, v. 23, n. 1, p. 1-16, 2022.
GOLPE, R. et al. Prevalence of major comorbidities in chronic obstructive pulmonary disease caused by biomass smoke or tobacco. Respiration, v. 94, n. 1, p. 38-44, 2017.
GONÇALVES-MACEDO, L. et al. Tendências da morbidade e mortalidade da DPOC no Brasil, de 2000 a 2016. Jornal Brasileiro de Pneumologia, v. 45, 2019.
KAUSHAL, M. et al. Chronic obstructive pulmonary disease and cardiac comorbidities: a cross-sectional study. Lung India: Official Organ of Indian Chest Society, v. 33, n. 4, p. 404, 2016.
LEVY, I. et al. Treatment of acute exacerbations of chronic obstructive pulmonary disease with acupuncture during hospitalization: a three-arm double-blinded randomized sham-controlled trial. Acupuncture in Medicine, v. 40, n. 6, p. 505-515, 2022.
PEREIRA, M. B. C. et al. Comparação da função e estrutura cardíaca e sua relação com a capacidade de exercício entre pacientes com DPOC estável e exacerbação aguda recente: estudo transversal. Jornal Brasileiro de Pneumologia, v. 48, 2022.
RAFIQ, R. et al. Vitamin D supplementation in chronic obstructive pulmonary disease patients with low serum vitamin D: a randomized controlled trial. The American Journal of Clinical Nutrition, v. 116, n. 2, p. 491-499, 2022.
ROVERSI, S. et al. Chronic obstructive pulmonary disease and cardiac diseases. An urgent need for integrated care. American Journal of Respiratory and Critical Care Medicine, v. 194, n. 11, p. 1319-1336, 2016.
SANTORO, A. et al. Tobacco smoking: risk to develop addiction, chronic obstructive pulmonary disease, and lung cancer. Recent Patents on Anti-cancer Drug Discovery, v. 14, n. 1, p. 39-52, 2019.
SU, K. C. et al. Fractional exhaled nitric oxide guided-therapy in chronic obstructive pulmonary disease: a stratified, randomized, controlled trial. Archivos de Bronconeumologia, v. 58, n. 8, p. 601-610, 2022.
TSAI, L. L. Y. et al. Physical activity levels improve following discharge in people admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease. Chronic Respiratory Disease, v. 13, n. 1, p. 23-32, 2016.
VOGELMEIER, C. F. et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. American Journal of Respiratory and Critical Care Medicine, v. 195, n. 5, p. 557-582, 2017.
WANG, J. X. et al. Efficacy of Xiyanping in the Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease and Its Effect on the Expression of GDF-15 and HIF-1α in Serum. Computational and Mathematical Methods in Medicine, v. 2022, p. 6193110, 2022.
XIA, J. et al. High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial. Critical Care, v. 26, n. 1, p. 1-10, 2022.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Kevillyn Maria Nava Flores , Catharina Carvalho Santana , Juan Carlos da Silva, Raphael Henrique Neres Ravazoli, Luiza Marcia Tavares do Nascimento , Petrônio Rufino Ferreira Bessa , Luciana ferreira dos Santos , Mirielly Santos Maracaipe , Jose Lucas Medeiros do Paraízo, Gabriela Fernandes Da Silva Clímaco, Artur Clímaco Da Silva Filho, Kayolane Coutinho Da Costa , Elizabeth lima da Silva , Virginia de Castro Lima