Keywords
How to Cite
Abstract
The HPV virus is directly linked to the development of genital cancer, genital warts and skin lesions. Knowing that HPV infection is a crucial factor in cervical cancer, HPV vaccination plays a fundamental role in reducing the incidence of cervical diseases and precancerous lesions. Study objectives: To analyze HPV vaccination coverage and its relationship with precursor lesions in the cervix, as well as other indicators of the disease. Methodology: A retrospective descriptive study was carried out in the southern region of Brazil, between 2014 and 2019, focusing on the female population that was the target of the vaccination campaign, excluding 9-year-old girls. Age groups from 10 to 19 years old and the general population were evaluated. Data were collected through the DATASUS Health Information System. Results found: In 2014, there was a higher percentage of girls vaccinated with the first and second dose, with 56.5% and 35.8%, respectively. From 2016 onwards, there was a reduction in vaccination coverage, especially in relation to the first dose. Even with vaccination starting in 2014, there was a 134% increase in cases of Cervical Intraepithelial Neoplasia (CIN) in the region until 2019. The age group from 14 to 19 years old was the most affected, with a predominance of cases of CIN 1. The number of cases of cervical cancer increased, both carcinoma (+63.6%) and adenocarcinoma. Discussion of results: The southern region of Brazil did not reach the target of 80% vaccination coverage established by the Ministry of Health. Final considerations: The need to reevaluate existing vaccination programs is evident, aiming to control diseases associated with HPV that could be prevented through immunization.
References
ALBRIGHT, Karen et al. Noninitiation and noncompletion of HPV vaccine among English-and Spanish-Speaking parents of adolescent girls: a qualitative study. Academic pediatrics, v. 17, n. 7, p. 778-784, 2017.
BRASIL, MINISTÉRIO DA SAÚDE. Informe técnico da ampliação da oferta das vacinas papilomavírus humano 6,11,16, Brasilia 2018.
Câncer do colo do útero. Instituto Nacional do Câncer. Disponível em: https://www.inca.gov.br/tipos-de-cancer/cancer-do-colo-do-utero.
DA FONSÊCA, Elizabeth Alvarenga Borges et al. Adesão de meninas à campanha de vacinação contra HPV no estado da paraíba em 2014. Revista de Ciências da Saúde Nova Esperança, v. 15, n. 1, p. 110-118, 2017.
DA SILVA TEIXEIRA, Antonia Maria; VIEIRA DA ROCHA, Cristina Maria. Monitoring of the vaccination coverage: a methodology for detection and intervention in risk situations. EPIDEMIOLOGIA E SERVICOS DE SAUDE, v. 19, n. 3, p. 217-226, 2010.
FEDRIZZ, E. N. Doenças Sexualmente Transmissíveis. Universidade Federal de Santa Catarina. Projeto HPV. Centro de Pesquisa Clínica. HPV e câncer de colo uterino. Ministério da saúde, 2013.
GOLDIE, Sue J. et al. Cost-effectiveness of HPV 16, 18 vaccination in Brazil. Vaccine, v. 25, n. 33, p. 6257-6270, 2007.
GRANDAHL, Maria et al. To consent or decline HPV vaccination: A pilot study at the start of the national school‐based vaccination program in sweden. Journal of school health, v. 87, n. 1, p. 62-70, 2017.
HOLOWATY, Philippa et al. Natural history of dysplasia of the uterine cervix. Journal of the National Cancer Institute, v. 91, n. 3, p. 252-258, 1999.
Instituto Nacional do Câncer José Alencar Gomes da Silva (INCA). Diretrizes brasileiras para o rastreamento do câncer do colo do útero. Rio de Janeiro, RJ: INCA, 2011.
JAISAMRARN, Unnop et al. Natural history of progression of HPV infection to cervical lesion or clearance: analysis of the control arm of the large, randomised PATRICIA study. PloS one, v. 8, n. 11, p. e79260, 2013.
LAIA, Bruni et al. Selviade’S. Cervical human papilloma virus prevalence in
continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis, v. 202, n. 12, p. 1789-99, 2010.
LEITE, Priscila Dantas; SOUSA, Albertina Duarte Takiuti; DE ABREU, Luiz Carlos. Conhecimento e aceitabilidade da vacina para o HPV entre adolescentes, pais e profissionais de saúde: elaboração de constructo para coleta e composição de banco de dados.
LIU, Guodong; KONG, Lan; DU, Ping. HPV vaccine completion and dose adherence among commercially insured females aged 9 through 26 years in the US. Papillomavirus Research, v. 2, p. 1-8, 2016.
MANOEL A. L, et al. Avaliação do conhecimento sobre o vírus do papiloma humano (HPV) e sua vacinação entre agentes comunitários de saúde na cidade de Tubarão, Santa Catarina, em 2014. Epidemiol. Serv. Saúde v.26
n.2 Brasília abr./jun. 2017
MCINDOE, WILLIAM A. et al. The invasive potential of carcinoma in situ of the cervix. Obstetrics and Gynecology, v. 64, n. 4, p. 451-458, 1984.
MELNIKOW, Joy et al. Natural history of cervical squamous intraepithelial lesions: a meta-analysis. Obstetrics & Gynecology, v. 92, n. 4, p. 727-735, 1998.
MINISTÉRIO DA SAÚDE. Secretaria de Vigilância em Saúde, Departamento de Vigilância de Doenças Sexualmente Transmissíveis, Coordenação-Geral do Programa Nacional de Imunizações: Informe técnico sobre a vacina Papilomavírus Humano (HPV) na atenção básica. Brasília, 2014.
MOSCICKI, Anna-Barbara. Impact of HPV infection in adolescent populations. Journal of Adolescent Health, v. 37, n. 6, p. S3-S9, 2005.
SCHILLER, J. T, et al. In: Plotkin, Stanley A.; Orenstein, Walter; Offit, Paul
A. (Orgs). Vaccines. Elsevier Saunders, 2013, p. 234-256.
SILVA, Gulnar Azevedo e. Cervical cancer control and HPV vaccine in Latin America. Revista Brasileira de Epidemiologia, v. 11, p. 514-515, 2008.
THULER, Luiz Claudio Santos; BERGMANN, Anke; CASADO, Letícia. Perfil das pacientes com câncer do colo do útero no Brasil, 2000-2009: estudo de base secundária. Revista brasileira de cancerologia, v. 58, n. 3, p. 351-357, 2012.
OSTÖR, A. G. Natural history of cervical intraepithelial neoplasia: a critical review. International journal of gynecological pathology: official journal of the International Society of Gynecological Pathologists, v. 12, n. 2, p. 186- 192, 1993.
ZANINI, Natalie Vieira et al. Motivos para recusa da vacina contra o Papilomavírus Humano entre adolescentes de 11 a 14 anos no município de Maringá-PR. Revista Brasileira de Medicina de Família e Comunidade, v. 12, n. 39, p. 1-13, 2017.
ZARDO, Geisa Picksius et al. Vaccines as an agent for immunization against HPV. Ciência & Saúde Coletiva, v. 19, n. 9, p. 3799, 2014.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Daniela freitas Luciano , Karollyne lemes Moreira , Yohan Resende Oliveira , Davi Oliveira Inácio da Silva , Joel Leonardo procopio Duarte, Julia Gabrieli Schmidt, Victor Hugo Júlio da Rosa , Maria Carla Guedes Rosa Machado, Any kelry Rodrigues Ferreira , Amanda Walter Manjabosco, Talita Oliveira Sousa , Jefferson da Silva Suquere , Clara Calixto Franco , Fernando Miron Filho