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Abstract
This paper proposes a literature review on neurogenetic biomarkers in Alzheimer's disease (AD), highlighting their fundamental role in early diagnosis and understanding of the disease's pathogenesis. The analysis covers the identification of specific genetic variants, such as those in the TOMM40 gene, and polymorphisms identified through genome-wide association studies (GWAS). Additionally, the differential expression of genes associated with AD in early stages offers a unique opportunity for more effective therapeutic interventions. Despite advances, challenges such as external validation and genetic variability are crucial. The neurogenetic approach represents progress in understanding the genetic heterogeneity in AD, providing a foundation for future research. The abstract highlights the promising implications of neurogenetic biomarkers and emphasizes the importance of ethical and social awareness.
References
Roses, A. D. (2010). An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease. Archives of Neurology, 67(5), 536-541.
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2010). Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature Genetics, 39(1), 17-23.
Hébert, S. S., Horré, K., Nicolaï, L., Papadopoulou, A. S., Mandemakers, W., Silahtaroglu, A. N., ... & De Strooper, B. (2008). Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proceedings of the National Academy of Sciences, 105(17), 6415-6420.
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Copyright (c) 2024 José Lucas Moura Vasconcelos, Aney Martins Evangelista Filho , Caio Mário do Couto Maldonado , Cacilda Soares de Moura Ramos , Gabriella Gamoski Maccare , Gilmara Gabrielli Gregory , Giulia Beatriz Rodrigues Barreira, Juliana Nogueira Leal de Moraes , Kahysa Magalhães de Oliveira, Laura Maria Câmara Silveira, Luiza Brito Dutra , Lucas de Lima Zaias , Matheus Franzotti Rozza , Nara Lis Freire Benigno, Nydia Lorena Siqueira Nieto , Rafaela Bollini Polycarpo, Shakespeare Viana Carvalho , Samara Oliveira Dantas , Sarah Geia Yaktine Fundación , Thauana Santana de Sá , Thatiane Carvalho Moreira