Antidepressants in Anxiety: A Comprehensive Approach to Efficacy and Mechanisms of Action.
Vol. 6 No. 1 (2024), Literature Review
Vol. 6 No. 1 (2024)

Antidepressants in Anxiety: A Comprehensive Approach to Efficacy and Mechanisms of Action.

Literature Review
https://doi.org/10.36557/2674-8169.2024v6n1p1716-1722
Published 2024-01-23
José Lucas Moura Vasconcelos
UniFG Guanambi
Amabile Manfroi
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0007-8015-709X
Antônio Carlos Gargioni Filho
Universidade de Cuiabá - UNIC
https://orcid.org/0000-0002-6449-5976
Carla Maria Zanelli Pinaty
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0002-9480-0537
Danyllo Fagundes Evangelista
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0001-7898-7955
Gilmara Gabrielli Gregory
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0005-9448-1013
Giordana Gregório Fritsch
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0000-7357-2649
Iara de Campos Brunetta
Universidade de Cuiabá - UNIC ◦
https://orcid.org/0009-0007-7670-1929
Izadora Fernanda Barros
Universidade de Cuiabá-UNIC
https://orcid.org/0009-0000-3230-4808
Kauara Marcelino Gonçalves
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0000-2383-8744
Lara de Campos Brunetta
Centro universitário de Várzea Grande - UNIVAG
https://orcid.org/0009-0007-6898-3671
Leonardo Gomes Silva Rosa
Universidade de Cuiabá- UNIC
https://orcid.org/0009-0004-1168-6009
Marcos Vinicius Maldonado de Barros Lacerda
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0002-5336-5559
Maria Clara de Alencar Figueiredo
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0006-2017-4771
Maria Eduarda Coelho de Menezes
Universidade de Cuiabá
https://orcid.org/0009-0005-6103-9499
Maria Eduarda Fornari Cenci
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0009-9815-5513
Maria Eduarda Miranda Sansão
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0009-0822-2752
Miguel Gramulha Filho
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0008-8152-563X
Nathalia Sofia Mayer Ceron
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0006-2861-2801
Thais Torres Galindo Dantas
Faculdade de Ciências Médicas de Jaboatão
https://orcid.org/0009-0008-1545-0924
Thiago Rodrigues de Oliveira
Universidade de Cuiabá - UNIC
https://orcid.org/0009-0000-2095-3819
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Keywords

Antidepressants
anxiety

How to Cite

Vasconcelos, J. L. M., Manfroi , A., Filho , A. C. G., Pinaty , C. M. Z., Evangelista , D. F., Gregory , G. G., Fritsch , G. G., Brunetta, I. de C., Barros , I. F., Gonçalves , K. M., Brunetta , L. de C., Rosa , L. G. S., Lacerda, M. V. M. de B., Figueiredo, M. C. de A., Menezes , M. E. C. de, Cenci , M. E. F., Sansão, M. E. M., Filho , M. G., Ceron , N. S. M., Dantas , T. T. G., & Oliveira, T. R. de. (2024). Antidepressants in Anxiety: A Comprehensive Approach to Efficacy and Mechanisms of Action. Brazilian Journal of Implantology and Health Sciences, 6(1), 1716–1722. https://doi.org/10.36557/2674-8169.2024v6n1p1716-1722
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Abstract

This paper conducts a comprehensive literature review on the role of antidepressants in the treatment of anxiety. The analysis includes controlled clinical trials and systematic reviews addressing the efficacy of different classes of antidepressants, with a primary focus on Selective Serotonin Reuptake Inhibitors (SSRIs) and tricyclic antidepressants. The results indicate that SSRIs, such as escitalopram, consistently demonstrate efficacy in reducing anxiety symptoms compared to placebos. Additionally, tricyclic antidepressants, although less commonly prescribed, have proven effective in specific situations, such as in the treatment of social anxiety disorder. The research emphasizes the importance of personalized treatment, considering factors such as the side effect profile, comorbidities, and individual patient characteristics. This personalized approach emerges as crucial for optimizing clinical outcomes and minimizing potential adverse effects.

https://doi.org/10.36557/2674-8169.2024v6n1p1716-1722
PDF (Português (Brasil))

References

Baldwin, D. S., Ajel, K., Masdrakis, V. G., Nowak, M., Rafiq, R., & Raphael, J. (2017). Efficacy of Escitalopram in the Treatment of Social Anxiety Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial. Journal of Clinical Psychopharmacology, 37(5), 550-558.

Bandelow, B., Sher, L., Bunevicius, R., Hollander, E., Kasper, S., Zohar, J., ... & Möller, H. J. (2018). Guidelines for the Pharmacological Treatment of Anxiety Disorders, Obsessive-Compulsive Disorder and Posttraumatic Stress Disorder in Primary Care. International Journal of Psychiatry in Clinical Practice, 22(2), 88-100.

Reynolds, C. F., Anderson, G. M., Brummett, B. H., & Smith, A. R. (2019). Imipramine for Social Anxiety Disorder: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial. Journal of Clinical Psychopharmacology, 39(1), 29-36.

Anderson, R. H., Williams, S. E., Johnson, M. R., & Brown, C. D. (2020). Tailoring Antidepressant Therapy for Anxiety: A Comprehensive Approach. Journal of Anxiety Disorders, 68, 102196.

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Copyright (c) 2024 José Lucas Moura Vasconcelos, Amabile Manfroi , Antônio Carlos Gargioni Filho , Carla Maria Zanelli Pinaty , Danyllo Fagundes Evangelista , Gilmara Gabrielli Gregory , Giordana Gregório Fritsch , Iara de Campos Brunetta, Izadora Fernanda Barros , Kauara Marcelino Gonçalves , Lara de Campos Brunetta , Leonardo Gomes Silva Rosa , Marcos Vinicius Maldonado de Barros Lacerda, Maria Clara de Alencar Figueiredo, Maria Eduarda Coelho de Menezes , Maria Eduarda Fornari Cenci , Maria Eduarda Miranda Sansão, Miguel Gramulha Filho , Nathalia Sofia Mayer Ceron , Thais Torres Galindo Dantas , Thiago Rodrigues de Oliveira