Promising Therapies for Obesity Control: A Comprehensive Review

Authors

  • Nilra Beatriz Pereira Dias Ribeiro Centro Universitário do Espírito Santo (UNESC) / Medicina
  • Maria Alice Marques Pinheiro Centro Universitário do Espírito Santo (UNESC) / Medicina
  • Marcos Renon Vogado Nogueira Universidade Ceuma - campus Imperatriz (CEUMA) / Medicina
  • Tábata Cléia Alves de Freitas Faculdade do ensino superior da Amazônia Reunida (FESAR) / Medicina
  • Laryssa Graziele Barbosa Miranda Faculdade de Medicina de Barbacena ( FAME) Medicina
  • Victória Albani Cassa Centro Universitário do Espírito Santo (UNESC) / Medicina
  • Jessica Luísa Moretto INSTITUTO TOCANTINENSE PRESIDENTE ANTÔNIO CARLOS (ITPAC Porto) / Medicina
  • César Barreiros Vieira Perez Faculdade Brasileira de Cachoeiro (MULTIVIX) / Medicina
  • Henrique Luchi Roldi Centro Universitário do Espírito Santo (UNESC) / Medicina
  • Ana Karla Alves do Carmo Instituto tocantinense Antônio Carlos Porto Nacional (ITPAC Porto) / Medicina
  • Vitória Fedeszen Mozdzen Centro Universitário do Espírito Santo (UNESC) / Medicina
  • Brenda Dias do Nascimento Faculdade São Leopoldo Mandic Campinas - Medicina
  • Júlia Rodrigues de Senna Mendonça Faculdade Ciências Médicas de Minas Gerais / Medicina
  • Antonio Emílio Couto Fardin Médico egresso pela Universidade Vila Velha (UVV) / Médico

DOI:

https://doi.org/10.36557/2674-8169.2024v6n1p626-642

Keywords:

Obesity; Therapeutics; Control.

Abstract

This study examines promising therapeutics for obesity control, addressing a variety of innovative and integrated approaches. Initially, the potential of pharmacological therapies, such as GLP-1 receptor agonists and SGLT-2 inhibitors, is highlighted, showcasing their effectiveness in weight reduction and improved glycemic control. Furthermore, the growing interest in interventions centered on the intestinal microbiota is emphasized, elucidating how manipulating bacterial composition can influence metabolism and contribute to weight loss.

Another notable aspect is the role of metabolic modulation therapies, such as blood flow restriction during exercise, with evidence indicating improvements in neural reactivity to food stimuli in obese individuals. Following this, behavioral strategies and psychological therapies, including cognitive-behavioral therapy and the promotion of healthy eating habits, are discussed as essential elements in the sustainable control of obesity over time.

In addition to pharmacological approaches, microbiota modulation, and behavioral strategies, this study underscores the need for a holistic understanding of obesity. The importance of incorporating personalized interventions, considering genetic, metabolic, and socioeconomic factors influencing an individual's response to proposed therapeutics, is emphasized. Adopting a patient-centered approach, the study highlights the necessity for continuous care and support over time, acknowledging the complexity of obesity control. In this regard, the research emphasizes not only the effectiveness of therapeutics but also the need for an integrated and personalized approach to comprehensively address this health challenge.

Finally, the importance of a multidisciplinary approach is emphasized, integrating different therapeutics to optimize outcomes in obesity control. The combination of pharmacological interventions, microbiota modulation, behavioral strategies, and psychological support emerges as a comprehensive and promising approach to tackle this global health challenge.

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References

Abdi Beshir, S. et al. A narrative review of approved and emerging anti-obesity medications. Saudi Pharmaceutical Journal, v. 31, p. 101757, 2023.

Benavides-Aguilar, J. A. et al. The Regulatory Role of MicroRNAs in Obesity and Obesity-Derived Ailments. Genes, v. 14, p. 2070, 2023.

Chakhtoura, M. et al. Pharmacotherapy of obesity: an update on the available medications and drugs under investigation. eClinicalMedicine, v. 58, p. 101882, 2023.

De Luca, M. et al. Bariatric Surgery for Patients with Overweight/Obesity. A Comprehensive Grading Methodology and Network Meta-analysis of Randomized Controlled Trials on Weight Loss Outcomes and Adverse Events. Obesity Surgery, v. 33, p. 4147–4158, 2023.

Imam, A. et al. Weight Loss Effect of GLP-1 RAs With Endoscopic Bariatric Therapy and Bariatric Surgeries. Journal of the Endocrine Society, v. 7, p. 1–10, 2023.

Jastreboff, A. M. & Kushner, R. F. New Frontiers in Obesity Treatment: GLP-1 and Nascent Nutrient-Stimulated Hormone-Based Therapeutics. Annual Review of Medicine, v. 74, p. 125–139, 2023.

Kamal, F. D. et al. Beyond Diet and Exercise: The Impact of Gut Microbiota on Control of Obesity. Cureus, v. 15, n. 11, p. e49339, 2023.

Klair, N. et al. What Is Best for Weight Loss? A Comparative Review of the Safety and Efficacy of Bariatric Surgery Versus Glucagon-Like Peptide-1 Analogue. Cureus, v. 15, n. 9, p. e46197, 2023.

Li, S. et al. The effect of blood flow restriction exercise on Nlactoylphenylalanine and appetite regulation in obese adults: a cross-design study. Frontiers in Endocrinology, v. 14, p. 1289574, 2023.

Poghosyan, V. et al. Spatiotemporal profile of altered neural reactivity to food images in obesity: Reward system is altered automatically and predicts efficacy of weight loss intervention. Frontiers in Neuroscience, v. 17, p. 948063, 2023.

Scott, A. W. et al. The Case for Bariatric Surgery in Patients with Class 1 Obesity. Current Surgery Reports, v. 11, p. 127–136, 2023.

Published

2024-01-10

How to Cite

Pereira Dias Ribeiro, N. B., Marques Pinheiro, M. A., Renon Vogado Nogueira , M., Alves de Freitas , T. C., Barbosa Miranda , L. G., Albani Cassa, V., Moretto , J. L., Barreiros Vieira Perez , C., Luchi Roldi , H., Alves do Carmo , A. K., Fedeszen Mozdzen , V., Dias do Nascimento , B., Rodrigues de Senna Mendonça , J., & Couto Fardin, A. E. (2024). Promising Therapies for Obesity Control: A Comprehensive Review . Brazilian Journal of Implantology and Health Sciences, 6(1), 626–642. https://doi.org/10.36557/2674-8169.2024v6n1p626-642

Issue

Section

Literature Review