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Abstract
Introduction: Cluster headache, a form of headache characterized by acute and intense
episodes of unilateral pain, often accompanied by autonomic symptoms, has been the focus
of considerable attention in the fields of neurology and genetics.
Methodology: This systematic literature review was conducted with the aim of exploring the
correlations between cluster headache and environmental and genetic variables, employing
a rigorous and comprehensive approach to identify relevant studies in the scientific
literature. The methodology adheres to recommended guidelines for systematic reviews,
prioritizing the inclusion of studies published between 2013 and 2023, with access to the full
text.
Results: It is crucial to recognize that the genetic pattern of cluster headache does not
present itself univocally, revealing a multifactorial complexity in its etiology. While genetic
factors may confer predisposition, their clinical expression appears to be modulated by
environmental influences. Studies exploring the interactions between genes and the
environment have focused on understanding how extrinsic factors, such as exposure to
certain environmental stimuli, can modulate genetic activity and play a role in triggering
cluster headache episodes.
Conclusion: Cluster headache represents a unique and challenging neurological condition
that continues to intrigue healthcare professionals and researchers. Its distinctive feature of
intense pain, accompanied by autonomic symptoms, adds to the complexity of the clinical
picture.
References
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Copyright (c) 2024 Maria Kéren Ribeiro Sousa, Luanna de Souza Côrtes Cremonez, Myllena Alves Rodrigues, André Barros Macêdo, Renata Silva Alves da Rocha, Raymara Thaise Amaral Silva, Eduarda Nakoula, Ikaro Oliveira Guimarães, Monara de Sena Fernandes, Gustavo Fagundes Santos, João Victor Laurindo, Rodrigo Teixeira Lemes, Pedro Henrique Dorneles Silva, Fernanda Paola de Carvalho