Keywords
TP53
Gene mutation
Oncogenesis
Cancer
How to Cite
Abstract
The TP53 gene, known as the “guardian of the genome”, encodes the p53 protein responsible for ensuring cellular integrity, inducing apoptosis of cells with changes in the genetic material. p53 dysfunction leads to the proliferation of mutated cells, which can result in a process of carcinogenesis. The present article aims to identify the relationship between mutations in the TP53 gene and oncogenesis processes. This is a narrative bibliographic review of the literature carried out based on articles published between 2005 and 2023 available in the PubMed, MEDLINE and Google Scholar databases in association with virtually available biobanks, such as Clinvar - NCBI. Different types of mutations in the TP53 gene have been identified, such as point mutations (SNP), copy number variations (SNP, CNVs) and insertion/deletion (InDel), which are related to changes in protein function and in the carcinogenesis process of neoplasms such as colorectal, lung and breast cancer. Studies have confirmed the relationship between mutations in the TP53 gene and oncogenesis processes, however it is difficult to measure the role of mutations in the prognosis of the disease, since cancer is a multifactorial disease that encompasses genetic and environmental factors.
References
ACHATZ, Maria Isabel Waddington et al. The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families. Cancer letters, v. 245, n. 1-2, p. 96-102, 2007.
BOCCARDO, E.; VILLA, L. L. Viral origins of human cancer. Current medicinal chemistry, v. 14, n. 24, p. 2526-2539, 2007.
BYKOV, VLADIMIR J N et al. “Targeting mutant p53 for efficient cancer therapy.” Nature reviews. Cancer vol. 18,2 (2018): 89-102. doi:10.1038/nrc.2017.109
COELHO, Anderson Lopes et al. Polimorfismo R72P do gene TP53 no câncer colorretal: metanálise. 2014.
CROCE, Carlo M. Oncogenes and cancer. New England journal of medicine, v. 358, n. 5, p. 502-511, 2008.
CUNHA, J. et al. Estudo epidemiológico do cancro do pulmão em Portugal nos anos de 2000/2002. Revista Portuguesa de Pneumologia, v. 13, n. 2, p. 255-265, 2007.
DA SILVA, Marcos Mendes; DA SILVA, Valquíria Helena. Envelhecimento: importante fator de risco para o câncer. Arquivos médicos do ABC, v. 30, n. 1, 2005.
DA SILVA PINHAL, Maria Aparecida et al. O papel da proteína HBx no desenvolvimento do hepatocarcinoma celular. Arquivos Médicos do ABC, v. 32, n. 1, 2007.
DE ALMEIDA, José Ricardo Chamhum et al. Marcadores tumorais: revisão de literatura. Revista Brasileira de Cancerologia, v. 53, n. 3, p. 305-316, 2007.
DE ANDRADE, Kelvin César et al. The TP53 database: transition from the International Agency for Research on Cancer to the US National Cancer Institute. Cell Death & Differentiation, v. 29, n. 5, p. 1071-1073, 2022.
DE SOUSA PINHO, Luana et al. Câncer de mama: da descoberta à recorrência da doença. Revista eletrônica de enfermagem, v. 9, n. 1, 2007.
DIAS, A. de A. et al. Fatores de risco genético e ambientais para o câncer gástrico. Revista cientifica multidisciplinar Núcleo do conhecimento, v. 10, n. 11, p. 63-72, 2016.
DINIZ, Telma Augusta. Mecanismos neoplásicos – entendendo o câncer. 2013. 21 p. In: PARANÁ. Secretaria de Estado da Educação. Os desafios da Escola Pública Paranaense na perspectiva do professor PDE. Produções Didático-pedagógicas. Cadernos PDE. Maringá: Universidade Estadual de Maringá, 2013. Vol. 2. p. 1-21.
FERNANDEZ-MERCADO, Marta et al. Targeted re-sequencing analysis of 25 genes commonly mutated in myeloid disorders in del (5q) myelodysplastic syndromes. Haematologica, v. 98, n. 12, p. 1856, 2013.
GALIOTTO, Dianne et al. Frequência de mutações no gene TP53 em tumores de mama em pacientes de Santa Catarina. 2011.
GANDIN, César A. Análise proteômica de células humanas in vitro expressando a oncoproteína LMP1 do vírus de Epstein-Barr (EBV). 2022.
HARRINGTON, Lea et al. Introduction to cancer biology. The Basic Science of Oncology, v. 4, p. 1-3, 2005.
KREIMER, Aimee R. et al. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiology Biomarkers & Prevention, v. 14, n. 2, p. 467-475, 2005.
KUWANO, Hiroyuki et al. Genetic alterations in esophageal cancer. Surgery today, v. 35, p. 7-18, 2005.
LACROIX, Marc; TOILLON, Robert-Alain; LECLERCQ, Guy. p53 and breast cancer, an update. Endocrine-related cancer, v. 13, n. 2, p. 293-325, 2006.
MARLEY AR, NAN H. Epidemiology of colorectal cancer. Int J Mol Epidemiol Genet. n.7, v.3, p.105-114, 2016.
OKADA, K. et al. Long-term outcomes of endoscopic submucosal dissection for undifferentiated-type early gastric cancer. Endoscopy, v. 44, n. 02, p. 122-127, 2012.
OSSA, Carlos Andrés; MOLINA, Gustavo; COCK-RADA, Alicia María. Síndrome de li-fraumeni. Biomédica, v. 36, n. 2, p. 182-187, 2016.
PAULA, Patricia Oliveira de et al. Análise de Alterações no Gene TP53 em Portadores de Câncer de Mama na População de Missal-PR. 2021. Trabalho de Conclusão de Curso.
PIACENTINI, Amanda Bernardini. Novas perspectivas para a biologia do câncer: compreendendo as metástases. 2012.
POMBO-DE-OLIVEIRA, M.S et al. Leucemias agudas: Abordagem imunomolecular no diagnóstico e na pesquisa. Instituto Nacional de Câncer. Ministério da Saúde. Rio de Janeiro, 2008.
POSSEBON, Aline Oliveira do Espírito Santo. Perfil da mulher militar quanto às medidas preventivas e diagnósticas contra o câncer de mama. 2020.
RUSSO, Antonio et al. The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment. Journal of clinical oncology, v. 23, n. 30, p. 7518-7528, 2005.
SGARDI, Flávia Celina; DO CARMO, Eliane Dias; ROSA, Luiz Fernando Blumer. Radiação ultravioleta e carcinogênese. Revista de Ciencias Medicas, v. 16, n. 4/6, 2007.
SILVA, Felipe C. et al. Hereditary breast and ovarian cancer: assessment of point mutations and copy 00number variations in Brazilian patients. BMC medical genetics, v. 15, p. 1-11, 2014.
SOBED - Sociedade Brasileira de Endoscopia Digestiva: https://www.sobed.org.br/a-sobed/pagina-inicial/
TOFETTI, Maria Helena de Faria Castro; DE OLIVEIRA, Vanessa Roberta. A importância do uso do filtro solar na prevenção do fotoenvelhecimento e do câncer de pele. Investigação, v. 6, n. 1, 2006.
STEF, Marianne A. et al. A DNA microarray for the detection of point mutations and copy number variation causing familial hypercholesterolemia in Europe. The Journal of Molecular Diagnostics, v. 15, n. 3, p. 362-372, 2013.
WANG, Xuyi; SIMPSON, Evan R.; BROWN, Kristy A. p53: protection against tumor growth beyond effects on cell cycle and apoptosis. Cancer research, v. 75, n. 23, p. 5001-5007, 2015.
World Health Organization (WHO). Cancer, 2018.
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Copyright (c) 2023 Amanda Pezzini Martins, Agnes Kiesling Casali, Aline Aparecida Silva Martins