Palavras-chave
transtornos psiquiátricos
saúde mental
ritmos circadianos
prevenção
intervenções terapêuticas
Como Citar
Resumo
Os distúrbios do sono desempenham papel fundamental no desenvolvimento e progressão de diversos transtornos psiquiátricos, incluindo depressão, ansiedade, transtorno bipolar, esquizofrenia e transtornos do neurodesenvolvimento. Esta revisão narrativa explora a complexa relação bidirecional entre o sono e a saúde mental, destacando fatores genéticos, neurobiológicos e ambientais que mediam essa associação. Evidências indicam que disfunções nos genes circadianos, alterações na microbiota intestinal e problemas de sono na infância são preditores robustos para o desenvolvimento de transtornos psiquiátricos. Além disso, distúrbios do sono estão fortemente ligados a sintomas psicóticos e comportamentos suicidas. Intervenções que visam à melhora da qualidade do sono podem ter efeitos terapêuticos e preventivos significativos, reforçando a necessidade de abordagens clínicas integradas.
Referências
ALFANO, C.; GAMBLE, A. The Role of Sleep in Childhood Psychiatric Disorders. Child & Youth Care Forum, v. 38, p. 327-340, 2009. doi.org/10.1007/S10566-009-9081-Y.
BASSETTI, C. et al. Neurology and psychiatry: waking up to opportunities of sleep. State of the art and clinical/research priorities for the next decade. European Journal of Neurology, v. 22, 2015. doi.org/10.1111/ene.12781.
CHARRIER, A. et al. Clock Genes and Altered Sleep-Wake Rhythms: Their Role in the Development of Psychiatric Disorders. International Journal of Molecular Sciences, v. 18, n. 5, p. 938, 2017. doi.org/10.3390/ijms18050938.
FERRARI, R. Writing narrative style literature reviews. Medical Writing, v. 24, n. 4, p. 230-235, 2015.
FUSAR-POLI, L. et al. The relationship between sleep disorders and psychotic-like symptoms in the general population. European Psychiatry, v. 64, p. S170, 2021. doi.org/10.1192/j.eurpsy.2021.451.
GOLDSTEIN, A.; WALKER, M. The role of sleep in emotional brain function. Annual Review of Clinical Psychology, v. 10, p. 679-708, 2014. doi.org/10.1146/annurev-clinpsy-032813-153716.
HARVEY, A. et al. Sleep disturbance as transdiagnostic: consideration of neurobiological mechanisms. Clinical Psychology Review, v. 31, n. 2, p. 225-235, 2011. doi.org/10.1016/j.cpr.2010.04.003.
HVOLBY, A. Associations of sleep disturbance with ADHD: implications for treatment. Attention Deficit and Hyperactivity Disorders, v. 7, p. 1-18, 2014. doi.org/10.1007/s12402-014-0151-0.
KRYSTAL, A. et al. Psychiatric disorders and sleep. Neurologic Clinics, v. 30, n. 4, p. 1389-1413, 2012. doi.org/10.1016/j.ncl.2012.08.018.
KURBEL, S. The human mind development as a reaction to improvements in memory: possible consequences on sleep, dreams and psychiatric disorders. Medical Hypotheses, v. 70, n. 3, p. 707-708, 2008. doi.org/10.1016/j.mehy.2007.07.005.
LAM, L.; LAM, M. Sleep Disorders in Early Childhood and the Development of Mental Health Problems in Adolescents: A Systematic Review of Longitudinal and Prospective Studies. International Journal of Environmental Research and Public Health, v. 18, n. 22, p. 11782, 2021. doi.org/10.3390/ijerph182211782.
MALIK, S. et al. The association between sleep disturbances and suicidal behaviors in patients with psychiatric diagnoses: a systematic review and meta-analysis. Systematic Reviews, v. 3, p. 18, 2014. doi.org/10.1186/2046-4053-3-18.
OHI, K. et al. Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study. Translational Psychiatry, v. 11, n. 1, p. 187, 2021. doi.org/10.1038/s41398-021-01308-8.
REEVE, S.; SHEAVES, B.; FREEMAN, D. Sleep Disorders in Early Psychosis: Incidence, Severity, and Association With Clinical Symptoms. Schizophrenia Bulletin, v. 45, p. 287-295, 2018. doi.org/10.1093/schbul/sby129. .
TURKISTANI, O. et al. Relationship Between Sleep Disorders and Mental Health. Journal of Healthcare Sciences, 2023. doi.org/10.52533/johs.2023.30601.
WAGNER-SKACEL, J. et al. Sleep and Microbiome in Psychiatric Diseases. Nutrients, v. 12, n. 8, p. 2198, 2020. doi.org/10.3390/nu12082198.
WANG, X.; CHENG, S.; XU, H. Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression. BMC Psychiatry, v. 19, 2019. doi.org/10.1186/s12888-019-2302-5.
WINKELMAN, J.; LECEA, L. Sleep and neuropsychiatric illness. Neuropsychopharmacology, v. 45, p. 1-2, 2019. doi.org/10.1038/s41386-019-0514-5.
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Copyright (c) 2025 Isabela Aiala Frare, Cecília Maria Rodrigues de França, Leandro Coelho Pettersen, Larisse Martins Costa Pettersen, Sabrina Maria Araújo de Sousa Lopes, João Victor Bastos Freire, Michele Covatti, Dágila Maria de Araújo Travi , Ana Estefanne Silveira, Márcio Júnior Azevedo Reis, Denys Alberto Rodrigues Santos Júnior , Maryanna Segatto, Lucas Badinelli Vaucher, Bruna Francielle Moreira Antunes , Nijair Araújo Pinto