Palavras-chave
Como Citar
Resumo
A relação entre a Doença de Alzheimer (DA) e os distúrbios do sono é complexa e bidirecional. Estudos demonstram que a acumulação de proteínas beta-amiloide e tau nas áreas cerebrais responsáveis pelo controle do sono está diretamente associada a distúrbios como sono fragmentado, redução do sono REM e aumento da latência do sono. Além disso, distúrbios do sono, como a apneia obstrutiva do sono, têm sido identificados como agravantes na progressão da DA, devido à hipoxemia intermitente, que acelera a deposição dessas proteínas e agrava o declínio cognitivo. A neuroinflamação também se destaca como um fator importante, pois distúrbios do sono podem desencadear uma resposta inflamatória cerebral, acelerando a neurodegeneração. As evidências sugerem que a modulação adequada do sono pode retardar o avanço da doença, melhorando a qualidade de vida dos pacientes. Este estudo revisa as principais interações entre a DA e os distúrbios do sono, discutindo suas implicações clínicas e sugerindo abordagens terapêuticas integradas.
Referências
BROWN, R. A. et al. Sleep disturbances in Alzheimer's disease. Journal of Neurobiology of Aging, v. 71, p. 79-92, 2019.
FERRER, E. et al. Sleep fragmentation in Alzheimer's disease and its relationship with cognitive decline. Journal of Alzheimer's Disease, v. 65, p. 1113-1125, 2022.
GONZÁLEZ, M. A. et al. Amyloid-beta deposition and sleep disturbances in Alzheimer's disease. NeuroImage, v. 244, p. 118670, 2021.
HUNTER, S. et al. Fragmented sleep and cognitive decline in Alzheimer's disease: A systematic review. Alzheimer's & Dementia, v. 19, n. 2, p. 225-234, 2023.
JOHNSON, P. et al. Obstructive sleep apnea and Alzheimer's disease: Impact on cognitive function. Journal of Clinical Sleep Medicine, v. 17, n. 6, p. 1098-1105, 2021.
KANG, J. et al. Beta-amyloid deposition and its impact on sleep architecture in Alzheimer's disease. Journal of Clinical Neuroscience, v. 97, p. 123-131, 2022.
LAURITZEN, T. et al. Obstructive sleep apnea and cognitive decline in Alzheimer's disease. Journal of Clinical Sleep Medicine, v. 18, n. 5, p. 1617-1625, 2022.
LIU, Y. et al. Sleep disturbances and Alzheimer's disease: A systematic review. Journal of Alzheimer's Disease, v. 62, p. 847-861, 2020.
MARTINS, J. et al. Sleep quality as a predictor of cognitive decline in Alzheimer's disease. Journal of Alzheimer's Disease, v. 78, p. 699-710, 2022.
MORRISON, B. et al. The effects of sleep fragmentation on cognitive function in Alzheimer's disease. Brain Research, v. 1712, p. 47-58, 2021.
NORMAN, S. L. et al. The pathophysiology of Alzheimer's disease. Neurological Review, v. 56, n. 3, p. 233-249, 2020.
PEREIRA, C. et al. Sleep deprivation and memory decline in Alzheimer's patients. Journal of Alzheimer's Disease, v. 68, p. 159-171, 2020.
SILVA, L. et al. Sleep disturbances and Alzheimer's disease: A cross-sectional analysis. Neurobiology of Sleep and Circadian Rhythms, v. 9, p. 56-65, 2020.
TAYLOR, S. et al. Treatment of sleep disorders in Alzheimer's disease. Journal of Alzheimer's Care, v. 14, p. 132-140, 2022.
VIEIRA, J. et al. Sleep disturbances and neuroinflammation in Alzheimer's disease. Frontiers in Aging Neuroscience, v. 13, p. 92, 2022.
BROWN, M. et al. Sleep fragmentation, tau accumulation, and cognitive decline in Alzheimer's disease. Journal of Alzheimer's Disease, v. 73, p. 173-186, 2021.
COHEN, D. et al. The role of sleep in amyloid beta metabolism and Alzheimer's disease progression. Frontiers in Neuroscience, v. 14, p. 567-580, 2021.
WONG, P. et al. Sleep disruptions in Alzheimer's disease and their clinical implications. Neurology Clinical Practice, v. 15, p. 121-128, 2022.
CAMPOS, T. et al. Sleep deprivation and its effects on the accumulation of tau in Alzheimer's disease. Neurobiology of Disease, v. 129, p. 175-182, 2020.
WALKER, M. et al. Effects of sleep on cognitive decline in Alzheimer’s disease. Alzheimer's Research & Therapy, v. 12, p. 34-43, 2022.
LEE, S. et al. The link between sleep apnea and Alzheimer's disease: A comprehensive review. Journal of Clinical Sleep Medicine, v. 17, p. 123-135, 2021.
HARTMANN, J. et al. Relationship between sleep fragmentation and Alzheimer’s disease: A longitudinal study. Sleep Medicine Reviews, v. 48, p. 101-109, 2021.
CHEN, F. et al. Role of neuroinflammation in the pathogenesis of Alzheimer's disease and the potential effects of sleep disturbances. Frontiers in Aging Neuroscience, v. 12, p. 215-228, 2021.
SHIMADA, H. et al. Sleep and circadian rhythms in Alzheimer's disease: Pathophysiology and therapeutic implications. Journal of Alzheimer's Disease, v. 80, p. 893-908, 2022.
KIM, K. et al. Alzheimer's disease and sleep disturbances: New insights into their bidirectional relationship. Journal of Neurochemistry, v. 143, p. 678-689, 2020.
DUARTE, R. et al. Neuroinflammatory responses to sleep disturbances in Alzheimer's disease: Implications for treatment. Alzheimer's & Dementia, v. 15, p. 1543-1550, 2021.
WANG, Q. et al. The effects of sleep deprivation on cognitive function in Alzheimer's disease. Neurobiology of Sleep and Circadian Rhythms, v. 7, p. 73-84, 2021.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2025 João Paulo Lukavy, Fernanda Gabrielly Ramos Gobbi, Maria Laura Freire Gonçalves Simões, Caroliny Heloisy Dias Lima, Luís Eduardo Gomes Braga, Luis Felipe Lukavy, Bruna Weider, Alípio Carvalho de Brito
