Current concept of the pathogenesis of peri-implantitis and the role of bactéria.
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Davis, A. ., & Davis, M. (2021). Current concept of the pathogenesis of peri-implantitis and the role of bactéria. Brazilian Journal of Implantology and Health Sciences , 3(5), 09-30.


Through an extensive review of the literature, our objective will be to clarify the current concept that exists about the pathogenesis of peri-implantitis, as well as the implications that bacteria may have on it. To date, different longitudinal and cross-sectional studies have identified some of the risk factors or risk indicators of peri-implantitis. Previous history of periodontal disease, diabetes, genetic load, poor oral hygiene, tobacco, alcohol consumption, absence of keratinized gingiva and the surface of the implants are some of the factors that have been analyzed in detail in the literature. The colonization of new surgically implanted surfaces represents a risk situation in partially edentulous patients, where periodontopathogenic bacteria from the residual bag play an important role.
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Aalam AA, Nowzari H. Clinical evaluation of dental implants with surfaces roughened by anodic oxidation, dual acidetched implants, and machined implants. The International Journal of Oral and Maxillofacial Implants 2005; 20: 793-8.

Albrektsson T, Isidor F. Consensus report session IV. In: Lang NP, Karring T. Proceedings of the First European Workshop on Periodontology. 1994; 365-9.

Albrektsson T, Wennerberg A. Oral implant surfaces: part 2 - review focusing on clinical knowledge of different surfaces. The International Journal of Prosthodontics. 2004; 17: 544-64.

Alsaadi G, Quirynen M, Komárek A, van Steenberghe D. Impact of local and systemic factors on the incidence of oral implant failures, up to abutment connection. J Clin Periodontol. 2007; 34 (7) Jul: 610-7.

Attard NJ, Zarb GA. A study of dental implants in medically treated hypothyroid patients. Clinical Implant Dentistry and Related Research. 2002; 4: 220-31.

Axelsson P, Lindhe J. Effect of controlled oral hygiene procedures on caries and periodontal disease in adults. Results after 6 years. Journal of Clinical Periodontology. 1981; 8: 239-48.

Baelum V, Ellegaard B. Implant survival in periodontally compromised patients. Journal of Periodontology. 2004; 75: 1404-12.

Baig MR, Rajan M. Effects of smoking on the outcome of implant treatment: a literature review. Indian J Dent Res 2007; 18: 190-5.

Bain CA, MoyPK. The association between the failure of dental implants and cigarette smoking. Int J Oral Maxilofac Implants. 1993; 8: 609-15.

Bain CA. Smoking and implant failure-Benefits of smoking cessation protocol. Int J Oral Maxilofac Implants. 1996; 11: 756-9.

Bain CA, Weng D, Meltzer A, Kholes SS, Stach RM. A metaanalysis evaluating the risk for implant failure in patients who smoke. Compend. 2002; 23: 695-706.

Berglundh T, Persson L, Klinge B. A systematic review of the incidence of biological and technical complications in implant dentistry reported in prospective longitudinal studies of at least 5 years. Journal of Clinical Periodontology. 2002; 29: 197-212.

Bergstrom J. Cigarette smoking as a risk factor in chronic periodontal disease. Community Dentistry and Oral Epidemiology. 1989; 17: 245-7.

Calistro, Lucas Cesar, et al. "Peri-implantite e mucosite peri-implantar. Fatores de risco, diagnóstico e tratamento." Brazilian Journal of Implantology and Health Sciences 2.3 (2020): 64-83.

Clares, Mario Dormani, and Sarmento George Scilio. "Tratamento clínico da peri-implantite com manutenção do tecido de granulação." Brazilian Journal of Implantology and Health Sciences 1.7 (2019): 192-206.

De Boever AL, De Boever JA. Early colonization of non-submerged dental implants in patients with a history of advanced aggressive periodontitis. Clinical Oral Implants Research. 2006; 17: 8-17.

Deluca, Habsha E, Zarb GA. ie effect of smoking on osseointegrated dental implants. Part I: Implant survival. Int J Prosthodont 2006; 19: 491-8.

Ellegaard B, Baelum V, Karring T. Implant therapy in periodontally compromised patients. Clinical Oral Implants Research. 1997; 8: 180-8.

Emrani J, Chee W, Slots J. Bacterial colonization of oral implants from nondental sources. Clin Implant Dent Relat Res. 2009 Jun; 11 (2): 106-12.

Esposito M, Hirsch JM, Leholm U, Thosen P. Biological factors contributing to failures of osteointegrated oral implants. (II) Etiopathogenesis. Eur J Oral Sci. 1998; 106: 721-64.

Feloutzis A, Lang NP, Tonetti MS, Bürgin W, Brägger, U, Buser, D, Duff GW, Kornman, KS. IL-1 genepolymorphism and smoking as risk factors for peri-implant bone loss in a well-maintained population. Clinical Oral Implants Research. 2003; 14: 10-7.

Ferreira S, Silva G, Cortelli J, Costa J, Costa F. Prevalence and risk variables for peri-implant disease in Brazilian subjects. Journal of Clinical Periodontology. 2006; 33: 929-35.

Fiorellini J, Nevins M. Dental implant considerations in the diabetic patient. Periodontology. 2000; 23: 73-7.

Fürst MM, Salvi GE, Lang NP, Persson GR. Bacterial colonization immediately after installation on oral titanium implants. Clin Oral Implants Res. 2007; 18: 501-8.

Galindo-Moreno P, Fauri M, Ávila-Ortiz G. Impact of smoking on marginal bone loss: A prospective study. Clin Oral Implants Res. 2005; 16: 579-86.

García-Calderón M, Cabezas Talavero J, Gallego Romero D, Torres Lagares D. Av Periodon Implantol 2004; 16 (1): 9-18.

Grössner-Schreiber B, Gripentrog M, Haustein I, et al. Plaque formation on surface-modified dental implants. An in Vitro study. Clin Oral Implants Res. 2001; 12: 543-51.

Gruica B, Wang HY, Lang NP, Buser, D. Impact of IL-1 genotype and smoking status on the prognosis of osseointegrated implants. Clinical Oral Implants Research. 2004; 15: 393-400.

Heitz-Mayfield LJ. Disease progression: identification of high-risk groups and individuals for periodontitis. J Clin Periodontol 2005; 32 (Suppl 6): 196-209.

Heitz-Mayfield LJA. Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol. 2008; 35 (Suppl. 8): 292-304.

Jansson H, Hamberg K, De Bruyn H, Brattha G. Clinical consequences of IL-1 genotype on early implant failures inpatients under periodontal maintenance. Clinical Implant Dentistry Related Research. 2005; 1: 51-9.

Karoussis IK, Kotsovilis S, Fourmousis, I. A comprehensive and critical review of dental implant prognosis in periodontally compromised partially edentulous patients. Clinical Oral Implants Research. 2007; 18: 669-79. [

Karoussis IK, Müller, S, Salvi G, Heitz-Mayfield LJA, Brägger U, Lang NP. Association between periodontal and peri-implant conditions: a 10-year prospective study. Clinical Oral Implants Research. 2004; 15: 1-7.

Klokkevold PR, Han TJ. How do smoking, diabetes, and periodontitis affect outcomes of implant treatment? Int J Oral Maxillofac Implants. 2007; 22 (Suppl): 173-20.

Kozlovsky A, Tal H, Laufer BZ, Leshem R, Rohrer MD, Weinreb M, Artzi Z. Impact of implant overloading on the peri-implant bone in inflamed and non-inflamed peri-implant mucosa. Clin. Oral Impl. Res. 2007; 18: 601-10.

Lachmann S, Kimmerle-Muller E, Axmann D, Scheideler L, Weber H, Haas R. Associations between peri-implant crevicular fluid volume, concentrations of crevicular inflammatory mediators, and composite IL-1A-889 and IL-1B 13954 genotype . A cross-sectional study on implant recall patients with and without clinical signs of peri-implantitis. Clinical Oral Implants Research. 2007; 18: 212-23.

Llanos, Alexandre Hugo, et al. "Impacto da periodontite agressiva e da periodontite crônica na qualidade de vida relacionada à saúde bucal." Brazilian Journal of Implantology and Health Sciences ISSN 2.8 (2020): 37-49.

Leonhardt A, et al. Five-year clinical, microbiological, and radiological outcome following treatment of peri-implatitis in man. J Periodontol 2003; 74: 1415-22.

Leonhardt A, Dahlén G. Effect of titanium on selected oral bacterial species in Vitro. Eur J Oral Sci. 1995; 103: 382-7.

Leonhardt A, Olsson J, Dahlén G. Bacterial colonization on titanium, hydroxyapatite, and amalgam surfaces in vivo. J Dent Res. 1995; 74: 1607-12.

Lindquist LW, Carrlsson GE, Jemt T. A prospective 15-years follow up study of mandibular fixed prostheses supported by osseointegrated implants. Clin Oral Implants Res. 1996; 7: 329-36.

Melo, Antônio Renato, Carlos Eduardo Vieira Gomes, and Fabio Alexandre Melo Campos. "Relação entre diabetes mellitus e o processo de osteointegração de implantes dentários." Brazilian Journal of Implantology and Health Sciences 1.5 (2019): 101-118.

Mundt T, Marck F, Schwahn C, Biffar R. Private practice results of screw-type tepered implants: Survival and evaluation risk factors. Int J Oral Maxilofac Implants. 2006; 21: 607-14.

Ong CTT, Ivanovski S, Needleman IG, Retzepi M, Moles DR, Tonetti MS, Donos N. Systematic review of implant outcomes in treated periodontitis subjects. J Clin Periodontol. 2008; 35: 438-62.

Quirynen M, Abarca M, Van Assche N, Nevins M, van Steenberghe D. Impact of supportive periodontal therapy and implant surface roughness on implant outcome in patients with a history of periodontitis. Journal of Clinical Periodontology. 2007; 34: 805-15.

Quirynen M, Bollen CM, Eysssen H, van Steenberghe D. Microbial penetration along the implant components of the Bränemark system. An in vivo study. Clin Oral Implants Res. 1994; 5: 239-44.

Quirynen M, De Soete M, Van Steenberghe D. Infectious risks for oral implants: a review of the literature. Clinical Oral Implants Research. 2002; 13: 1-19.

Paraguassu, Éber Coelho, et al. "Implant installation in patients with periodontal disease history." Research, Society and Development 9.2 (2020): e39922009-e39922009.

Renvert S, Persson GR. Periodontitis as a potential risk factor for peri-implantitis. J Clin Periodontol. 2009; 36 (Suppl. 10): 9-14.

Rimondini L, Farè S, Brambilla E, Felloni A, Consonni C, Brossa F, Carrassi A. The effect of surface roughness on early in vivo plaque colonization on titanium. J Periodontol. 1997; 68: 556-62.

Roos-Jansa o ker AM, Renvert H, Lindahl Ch, Renvert S. Nine-to fourteen-year followup of implant treatment. Part III: factors associated with peri-implant lesions. J Clin Periodontol. 2006; 33: 296-301.

Rosan B, Lamont RJ. Dental plaque formation. Microbes Infection. 2000; 2: 1599-607.

Rutar A, Lang N, Buser D, Burgin W, Mombelli A. Retrospective assessment of clinical and microbiological factors affecting peri-implant tissue conditions. Clin Oral Implant Res. 2001; 12: 189-95.

Salvi GE, Fürst MM, Lang NP, Persson GR. One-year bacterial colonization patterns of Staphylococcus aureus and other bacteria at implants and adjacent teeth. Clin. Oral Impl. Res. 2008; 19: 242-8.

Sánchez-Pérez A, Moya-Villaescusa MJ, Caffesse RG. (2007) Tobacco as a risk factor for survival of dental implants. J Periodontol. 2007 Feb; 78 (2): 351-9.

Scarano A, Piattelli M, Vrespa G, Caputi S, Piattelli A. Bacterial adhesion on titanium nitride-coated and uncoated implants: An in vivo human study. J Oral Implantol. 2003; 29: 80-5.

Schwartz-Arad, Samet N, Mamlider A. Smoking and complications of endosseous dental implants. J Periodontol. 2002; 73: 153-7.

Serino G, Ström C. Peri-implantitis in partially edentulous patients: association with inadequate plaque control. Clin Oral Impl Res. 2009; 20: 169-74.

Shwartz-Arad D, Samet N, Samet N, Mamlider A. Smoking and complications of endosseous dental implants. J Periodontol. 2002; 73: 152-7.

Socransky SS, Haffajee AD. Microbial periodontal ecology. Periodontology 2000. 2005; 38: 135-87.

Subramani K, Jung RE, Molenberg A, Hammerle CH. Biofilm on dental implants: a review of the literature. Int J Oral Maxillofac Implants. 2009 Jul-Aug; 24 (4): 616-26.

Tolstunov L. Implant zones of the jaws: implant location and related success rate. Journal of Oral Implantology. 2007; 33: 211-20.

van Winkelhoff AJ, Goene RJ, Benschop C, Folmer T. Early colonization of dental implants by putative periodontal pathogens in partially edentulous patients. Clinical Oral Implants Research. 2000; 11: 511-20.

Warrer K, Buser D, Lang NP, Karring T. Plaque-induced peri-implantitis in the presence or absence of keratinized mucosa. An experimental study in monkeys. Clin Oral Implants Res. 1995; 6: 131-8.

Wennstrom Jl, Bengazi F, Lekholm U. The influence of the masticatory mucosa on the peri-implant soft tissue condition. Clin Oral Implants Res. 1994; 5: 1-8.

Westfelt E, Rylander H, Blohne G, Joanasson P, Lindhe J. The effect of periodontal therapy in diabetes. Journal of Clinical Periodontology. 1996; 23: 92-100.

Zitzmann NU, Berglundh T. Definition and prevalence of peri-implant disease. Journal of Clinical Periodontology 2008; 35: 286-91.

Weyant RJ, Burt BA. An assessment of survival rates and within patient clustering of failures for endosseous oral implants. J Dent Res. 1993; 72 (1): 2-8.

Weyant RJ. Characteristics associated with the loss and periimplant tissue health of endosseous dental implants. Int J Oral and Maxillofac Implants. 1994; 9 (1): 95-102.

Wu-Yuan CD, Eganhouse KJ, Keller JC, Walters KS. Oral bacterial attachment to titanium surfaces: A scanning electron microscopy study. J Oral Implantol. 1995; 21: 207-13.

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