Palavras-chave
Como Citar
Resumo
Investigating the cardiovascular effects of natural compounds, such as linalool, has aroused interest due to the potential impact on cardiovascular health. Linalool, a component present in several essential oils, has demonstrated promising pharmacological properties, including antihypertensive activity. However, its bioavailability and efficacy can be influenced by complexation with β-cyclodextrin, a strategy frequently used to improve the solubility and stability of bioactive substances. This study aimed to carry out a systematic review of the literature, exploring the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin. Objective: To investigate the cardiovascular effects of free linalool and linalool complexed with β-cyclodextrin, with emphasis on the antihypertensive action, through a systematic review of the literature. Methodology: The review was conducted according to PRISMA guidelines. The PubMed, Scielo and Web of Science databases were consulted, using the descriptors "linalool", "β-cyclodextrin", "cardiovascular effects", "antihypertensive" and "complexation". The inclusion criteria covered studies published in the last 10 years, focusing on in vivo experiments, clinical trials and systematic reviews. Articles unrelated to the topic, duplicate studies and those without peer review were excluded. Results: They revealed that linalool, when complexed with β-cyclodextrin, presented greater bioavailability and stability, enhancing its antihypertensive action. In vivo studies have demonstrated a significant reduction in blood pressure in hypertensive animal models. Furthermore, the complexation positively influenced the gastrointestinal absorption of linalool. These findings suggest that the complexed formulation may represent an effective approach to improving the cardiovascular effects of linalool. Conclusion: The systematic review highlights the relevance of complexing linalool to β-cyclodextrin as a strategy to enhance its antihypertensive effects. Understanding these mechanisms can contribute to the development of more effective pharmaceutical formulations in the management of hypertension, promoting advances in cardiovascular therapy.
Referências
Phu HT, Thuan DTB, Nguyen THD, Posadino AM, Eid AH, Pintus G. Herbal Medicine for Slowing Aging and Aging-associated Conditions: Efficacy, Mechanisms and Safety. Curr Vasc Pharmacol. 2020;18(4):369-393. doi: 10.2174/1570161117666190715121939.
Dias P, Tvrdý V, Jirkovský E, Dolenc MS, Peterlin Mašič L, Mladěnka P. The effects of bisphenols on the cardiovascular system. Crit Rev Toxicol. 2022 Jan;52(1):66-87. doi: 10.1080/10408444.2022.2046690.
Obradovic M, Zafirovic S, Soskic S, Stanimirovic J, Trpkovic A, Jevremovic D, Isenovic ER. Effects of IGF-1 on the Cardiovascular System. Curr Pharm Des. 2019;25(35):3715-3725. doi: 10.2174/1381612825666191106091507.
Xia N, Daiber A, Förstermann U, Li H. Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol. 2017 Jun;174(12):1633-1646. doi: 10.1111/bph.13492.
Vaccaro O, Lucisano G, Masulli M, Bonora E, Del Prato S, Rivellese AA, Giorda CB, Mocarelli P, Squatrito S, Maggioni AP, Riccardi G, Nicolucci A; TOSCA.IT Investigators. Cardiovascular Effects of Pioglitazone or Sulfonylureas According to Pretreatment Risk: Moving Toward Personalized Care. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3296-3302. doi: 10.1210/jc.2019-00361.
Gyöngyösi M, Alcaide P, Asselbergs FW, Brundel BJJM, Camici GG, Martins PDC, Ferdinandy P, Fontana M, Girao H, Gnecchi M, Gollmann-Tepeköylü C, Kleinbongard P, Krieg T, Madonna R, Paillard M, Pantazis A, Perrino C, Pesce M, Schiattarella GG, Sluijter JPG, Steffens S, Tschöpe C, Van Linthout S, Davidson SM. Long COVID and the cardiovascular system-elucidating causes and cellular mechanisms in order to develop targeted diagnostic and therapeutic strategies: a joint Scientific Statement of the ESC Working Groups on Cellular Biology of the Heart and Myocardial and Pericardial Diseases. Cardiovasc Res. 2023 Mar 31;119(2):336-356. doi: 10.1093/cvr/cvac115.
Miller MR. Oxidative stress and the cardiovascular effects of air pollution. Free Radic Biol Med. 2020 May 1;151:69-87. doi: 10.1016/j.freeradbiomed.2020.01.004.
Macvanin M, Gluvic Z, Radovanovic J, Essack M, Gao X, Isenovic ER. New insights into the cardiovascular effects of IGF-1. Front Endocrinol (Lausanne). 2023 Feb 9;14:1142644. doi: 10.3389/fendo.2023.1142644.
Zhang XX, Zhao DS, Wang J, Zhou H, Wang L, Mao JL, He JX. The treatment of cardiovascular diseases: a review of ferulic acid and its derivatives. Pharmazie. 2021 Feb 25;76(2):55-60. doi: 10.1691/ph.2021.0958.
Hughes WE, Beyer AM, Gutterman DD. Vascular autophagy in health and disease. Basic Res Cardiol. 2020 Jun 6;115(4):41. doi: 10.1007/s00395-020-0802-6.
Lundberg JO, Carlström M, Weitzberg E. Metabolic Effects of Dietary Nitrate in Health and Disease. Cell Metab. 2018 Jul 3;28(1):9-22. doi: 10.1016/j.cmet.2018.06.007.
Wu J, Hu W, Gong Y, Wang P, Tong L, Chen X, Chen Z, Xu X, Yao W, Zhang W, Huang C. Current pharmacological developments in 2,3,4',5-tetrahydroxystilbene 2-O -β-D-glucoside (TSG). Eur J Pharmacol. 2017 Sep 15;811:21-29. doi: 10.1016/j.ejphar.2017.05.037.
Giesinger RE, McNamara PJ. Hemodynamic instability in the critically ill neonate: An approach to cardiovascular support based on disease pathophysiology. Semin Perinatol. 2016 Apr;40(3):174-88. doi: 10.1053/j.semperi.2015.12.005.
Iovino M, Iacoviello M, De Pergola G, Licchelli B, Iovino E, Guastamacchia E, Giagulli VA, Triggiani V. Vasopressin in Heart Failure. Endocr Metab Immune Disorder Drug Targets. 2018;18(5):458-465. doi: 10.2174/1871530318666180212095235.
Jarvie JL, Pandey A, Ayers CR, McGavock JM, Sénéchal M, Berry JD, Patel KV, McGuire DK. Aerobic Fitness and Adherence to Guideline-Recommended Minimum Physical Activity Among Ambulatory Patients With Type 2 Diabetes Mellitus. Diabetes Care. 2019 Jul;42(7):1333-1339. doi: 10.2337/dc18-2634.
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Jordana Clara Gomes Pedreira, Edward Rodrigues de Oliveira Filho, Héllida Patrícia Oliveira Camilo Pereira, Anderson Felipe Caixêta Martins, , Felipe Dayrell Schoepfer, Rafaella Ribeiro Gomes Nogueira, Jim Davis de Oliveira, Herik Jansen de Souza Pimentel, Josiely Anelise Mendonça, Paulo Otávio Magalhães Costa, Nara Márcia Amaro Domingos Guimarães , Vinícius Guimarães